scholarly journals Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects

2018 ◽  
Vol 30 (12) ◽  
pp. e13463 ◽  
Author(s):  
Helen Parker ◽  
Caroline L Hoad ◽  
Emily Tucker ◽  
Carolyn Costigan ◽  
Luca Marciani ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Test Meal ◽  
Healthy Subjects ◽  
Reference Intervals ◽  
Sensory Function ◽  
Resonance Imaging

scholarly journals Magnetic resonance imaging of the pharynx in OSA patients and healthy subjects

2001 ◽  
Vol 17 (1) ◽  
pp. 79-86 ◽  
Author(s):  
M.A. Ciscar ◽  
G. Juan ◽  
V. Martinez ◽  
M. Ramon ◽  
T. Lloret ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Healthy Subjects ◽  
Resonance Imaging

scholarly journals POS0294 PROFILE OF SPINAL TUMORS IN RHEUMATOLOGY DEPARTMENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 372.2-372
Author(s):  
B. A. Hiba ◽  
H. Sahli ◽  
S. Boussaid ◽  
S. Nouicer ◽  
S. Jemmali ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Signal Intensity ◽  
Spinal Tumor ◽  
Sensory Function ◽  
Spinal Tumors ◽  
Vertebral Compression Fractures ◽  
Myxopapillary Ependymoma ◽  
Resonance Imaging ◽  
Weighted Sequences

Background:Spine tumors remain a hot topic because of their associated morbidity by affecting motor and sensory function. Contrary to metastatic spine disease (MSD), extremely prevalent, rise within or surrounding the spinal cord and/or vertebral column, primary spinal tumors are rare, 5% of all primary skeletal tumors and frequently benign (20%). The diagnostic delay of these tumors, even when benign, is associated with a poor prognosis. Establishing the correct diagnosis is heavily reliant on magnetic resonance imaging and histological confirmation.Objectives:to provide an overview of the epidemiology, radiological and histopathological of spinal tumors diagnosed in a rheumatology department.Methods:A retrospective study consisting of clinical characteristics analysis, laboratory and x-ray examinations, was performed on 40 patients who were hospitalised for a spinal tumor, in a rheumatology department, over 5-year period from 2015 to 2020.Results:A total of 40 patients with a mean age of 66 ± 13.5 years [18-93] and a sex-ratio of 1.1, were included. The most common initial complaints were inflammatory back pain (67.5%) and fatigue (52.5%), with a median duration of 5 months. Physical examination abnormalities included lumbar stiffness (32.5%), radicular signs (18.7%), hepatomegaly (12.5%), and lymphadenopathy (17.5%). Neurological deficit was found in only 3 patients (7.5%). Hypercalcemia (corrected serum calcium > 105 mg/l), and anemia (hemoglobin (Hb) < 100 g/l in female, Hb <110g/l in male) were present initially in respectively 47.5% and 46.3% patients, while biological inflammatory syndrome was present in 89.7% patients (median C-reactive protein of 44.7). Tumor markers were performed in 12 patients and they were positive in 9 of them.Plain radiographs findings were vertebral compression fractures (43.6%), osteolytic lesions (30.8%) and osteoblastic lesions (12.5%). Lumbar spine was the most affected (57.5%), followed by the dorsal spine (45%). Magnetic resonance imaging (MRI) was performed in 55%, and the most common lesion was low signal intensity on T1-weighted sequences and high signal intensity on T2-weighted sequences (68.1%).In our study, only one patient was diagnosed for a myxopapillary ependymoma, a benign primary spinal tumor characterised by a metastatic dissemination risk. For the rest (39 patients), the diagnosis of bone metastasis, multiple myeloma (57.7%), and of solid tumor cancers (40%), were established. Primary cancers were mainly prostate cancer (37.5%), lung cancer (18.7%) and kidney cancer (18.7%). By a median follow-up time of 25 months, overall survival rate was 30%.Conclusion:Extradural lesions are the most common, and are typically metastatic. Special attention should be pain to the patient’s medical history and laboratory abnormalities. In fact, an early diagnosis requires a high index of clinical suspicion.Disclosure of Interests:None declared

AB1098 STRUCTURAL ELEMENTS OF THE KNEE ENTHESES ASSESSED IN HEALTHY SUBJECTS WITH ULTRA HIGH FIELD MRI (150 MICRONS).

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1838-1838
Author(s):  
D. Roche ◽  
C. Michel ◽  
P. Daudé ◽  
A. Le Troter ◽  
C. Chagnaud ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Healthy Subjects ◽  
High Field ◽  
T2 Mapping ◽  
Pulse Sequences ◽  
Structural Elements ◽  
Resonance Imaging ◽  
Ultra High Field ◽  
Mineralized Zone

Background:Fibrocartilaginous enthesis is composed of different histological zones which are commonly referred to the tendon distal extremity (a lamellar tissue with a low cell density, collagen and connective tissue), the fibrocartilaginous zone (with chondrocytes), a progressively mineralized zone and the bone. The MRI visualization of the water content of entheses is challenging given the very short relation time so that entheses has been very poorly assessed using MRI (1).Objectives:The main objective of the study was to assess the structural elements of the knee enthesis based on the quantitative T2* measurements using Ultra High Field (UHF) MRI.Methods:Twelve healthy subjects without any osteoarticular pathology were included in the study after they provided their informed consent. 3D gradient echo sequence with a 4.3 ms echo time and T2* mapping were performed. The lateral internal, external and crossed ligaments, patellar and quadricipital tendons were assessed. T2* measurements were performed specifically on the quadricipital tendon.Results:The quadricipital tendon and the bone trabeculation could be visualized on the UHF MR image. The T2* mapping analysis illustrated a large value (16.4 ± 4 ms) for the subchondral bone and much lower values for the trabecular bone (11 ± 4.5 ms) and the different zones of the keen entheses (7.7 ± 1.9 ms).Conclusion:Based on T2* measurements performed using UHF MRI, the different structural elements of the knee entheses were distinguished. This quantitative stratification could be used to assess changes in pathological conditions such as SpA and trauma.References:[1]Benjamin M, Bydder GM. Magnetic resonance imaging of entheses using ultrashort TE (UTE) pulse sequences. Journal of magnetic resonance imaging: JMRI. 2007;25(2):381-9.Disclosure of Interests:None declared

scholarly journals Magnetic resonance imaging measurement of blood volume flow in peripheral arteries in healthy subjects

2003 ◽  
Vol 38 (5) ◽  
pp. 1060-1066 ◽  
Author(s):  
Willemijn M Klein ◽  
Lambertus W Bartels ◽  
Liesbeth Bax ◽  
Yolanda van der Graaf ◽  
Willem P.Th.M Mali
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Blood Volume ◽  
Healthy Subjects ◽  
Volume Flow ◽  
Peripheral Arteries ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Measurement

scholarly journals Cerebral Functional Magnetic Resonance Imaging Activation Modulated by a Single Dose of the Monoamine Neurotransmission Enhancers Fluoxetine and Fenozolone during Hand Sensorimotor Tasks

1999 ◽  
Vol 19 (12) ◽  
pp. 1365-1375 ◽  
Author(s):  
Isabelle Loubinoux ◽  
Keder Boulanouar ◽  
Jean-Philippe Ranjeva ◽  
Christophe Carel ◽  
Isabelle Berry ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Single Dose ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Motor Activity ◽  
Healthy Subjects ◽  
Drug Effects ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging

Fluoxetine inhibits the reuptake of serotonin, and dextroamphetamine enhances presynaptic release of monoamines. Although the excitatory effect of both noradrenaline and dopamine on motor behavior generally is accepted, the role of serotonin on motor output is under debate. In the current investigation, the authors evidenced a putative role of monoamines and, more specifically, of serotonin in the regulation of cerebral motor activity in healthy subjects. The effects on cerebral motor activity of a single dose of fluoxetine (20 mg), an inhibitor of serotonin reuptake, and fenozolone (20 mg/50 kg), an amphetamine-like drug, were assessed by functional magnetic resonance imaging. Subjects performed sensorimotor tasks with the right hand. Functional magnetic resonance imaging studies were performed in two sessions on two different days. The first session, with two scan experiments separated by 5 hours without any drug administration, served as time-effect control. A second, similar session but with drug administration after the first scan assessed drug effects. A large increase in evoked signal intensity occurred in the ipsilateral cerebellum, and a parallel, large reduction occurred in primary and secondary motor cortices (P < 10–3). These results are consistent with the known effects of habituation. Both drugs elicited comparable effects, that is, a more focused activation in the contralateral sensorimotor area, a greater involvement of posterior supplementary motor area, and a widespread decrease of bilateral cerebellar activation (P < 10–3). The authors demonstrated for the first time that cerebral motor activity can be modulated by a single dose of fluoxetine or fenozolone in healthy subjects. Drug effects demonstrated a direct or indirect involvement of monoamines and serotonin in the facilitation of cerebral motor activity.

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