scholarly journals Within‐individual repeatability in telomere length: A meta‐analysis in nonmammalian vertebrates

2021 ◽  
Author(s):  
Tiia Kärkkäinen ◽  
Michael Briga ◽  
Toni Laaksonen ◽  
Antoine Stier
Keyword(s):  
Telomere Length ◽  
Meta Analysis ◽  
Individual Repeatability

scholarly journals Within-individual repeatability in telomere length: a meta-analysis in non-mammalian vertebrates

2021 ◽  
Author(s):  
Tiia Kärkkäinen ◽  
Michael Briga ◽  
Toni Laaksonen ◽  
Antoine Stier
Keyword(s):  
Telomere Length ◽  
Phylogenetic Signal ◽  
Meta Analysis ◽  
Biological Factors ◽  
Long Term Outcomes ◽  
Term Survival ◽  
High Repeatability ◽  
Individual Repeatability ◽  
Species Lifespan

Telomere length is increasingly used as a biomarker of long-term life history costs, ageing and future survival prospects. Yet, to have the potential to predict long-term outcomes, telomere length should exhibit a relatively high within-individual repeatability over time, which has been largely overlooked in past studies. To fill this gap, we conducted a meta-analysis on 74 studies reporting longitudinal telomere length assessment in non-mammalian vertebrates, with the aim to establish the current pattern of within-individual repeatability in telomere length and to identify the methodological (e.g. qPCR/TRF, study length) and biological factors (e.g. taxon, wild/captive, age class, species lifespan, phylogeny) that may affect it. While the median within-individual repeatability of telomere length was moderate to high (R = 0.55; 95% CI: 0.05-0.95; N = 82), marked heterogeneity between studies was evident. Measurement method affected strongly repeatability estimate, with TRF-based studies exhibiting high repeatability (R = 0.80; 95% CI: 0.34-0.96; N = 25), while repeatability of qPCR-based studies was only half of that and more variable (R = 0.46; 95% CI: 0.04-0.82; N = 57). While phylogeny explained some variance in repeatability, phylogenetic signal was not significant (λ = 0.32; 95% CI: 0.00-0.83). None of the biological factors investigated here had a statistically significant association with the repeatability of telomere length, being potentially obscured by methodological noise. Our meta-analysis highlights the need to carefully evaluate and consider within-individual repeatability in telomere studies to ensure the robustness of using telomere length as a biomarker of long-term survival and fitness prospects.

Systematic review and meta‐analysis of the association between paediatric obesity and telomere length

2021 ◽  
Author(s):  
Li Lin ◽  
Kang Qin ◽  
Dezhong Chen ◽  
Ciyong Lu ◽  
Weiqing Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Telomere Length ◽  
Meta Analysis ◽  
Paediatric Obesity

Decline in telomere length with increasing age across nonhuman vertebrates: A meta‐analysis

2021 ◽  
Author(s):  
Florentin Remot ◽  
Victor Ronget ◽  
Hannah Froy ◽  
Benjamin Rey ◽  
Jean‐Michel Gaillard ◽  
...  
Keyword(s):  
Telomere Length ◽  
Meta Analysis

scholarly journals Perceived stress and telomere length: A systematic review, meta-analysis, and methodologic considerations for advancing the field

2016 ◽  
Vol 54 ◽  
pp. 158-169 ◽  
Author(s):  
Maya B. Mathur ◽  
Elissa Epel ◽  
Shelley Kind ◽  
Manisha Desai ◽  
Christine G. Parks ◽  
...  
Keyword(s):  
Systematic Review ◽  
Telomere Length ◽  
Perceived Stress ◽  
Meta Analysis

Leukocyte telomere length in patients with bipolar disorder: An updated meta-analysis and subgroup analysis by mood status

2018 ◽  
Vol 270 ◽  
pp. 41-49 ◽  
Author(s):  
Yu-Chi Huang ◽  
Liang-Jen Wang ◽  
Ping-Tao Tseng ◽  
Chi-Fa Hung ◽  
Pao-Yen Lin
Keyword(s):  
Bipolar Disorder ◽  
Telomere Length ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Leukocyte Telomere Length

Abstract 4654: Telomere length as a biomarker of cancer risk: Review and meta-analysis

2011 ◽  
Author(s):  
Ingrid M. Wentzensen ◽  
Lisa Mirabello ◽  
Ruth M. Pfeiffer ◽  
Sharon A. Savage
Keyword(s):  
Cancer Risk ◽  
Telomere Length ◽  
Meta Analysis ◽  
Risk Review

scholarly journals Telomere length: how the length makes a difference

2020 ◽  
Vol 47 (9) ◽  
pp. 7181-7188 ◽  
Author(s):  
M. Lulkiewicz ◽  
J. Bajsert ◽  
P. Kopczynski ◽  
W. Barczak ◽  
B. Rubis
Keyword(s):  
Telomere Length ◽  
Meta Analysis ◽  
Telomerase Activity ◽  
Human Cells ◽  
Attrition Rate ◽  
Severe Damage ◽  
Telomere Attrition ◽  
Adult Men ◽  
Cell Life ◽  
Real Value

Abstract Telomerase is perceived as an immortality enzyme that might provide longevity to cells and whole organisms. Importantly, it is generally inactive in most somatic cells of healthy, adult men. Consequently, its substrates, i.e. telomeres, get shorter in most human cells with time. Noteworthy, cell life limitation due to telomere attrition during cell divisions, may not be as bad as it looks since longer cell life means longer exposition to harmful factors. Consequently, telomere length (attrition rate) becomes a factor that is responsible for inducing the signaling that leads to the elimination of cells that lived long enough to acquire severe damage. It seems that telomere length that depends on many different factors (including telomerase activity but also genetic factors, a hormonal profile that reflects sex, etc.) might become a useful marker of aging and exposition to stress. Thus in the current paper, we review the factors that affect telomere length in human cells focusing on sex that all together with different environmental and hormonal regulations as well as parental aspect affect telomere attrition rate. We also raise some limitations in the assessment of telomere length that hinders a trustworthy meta-analysis that might lead to acknowledgment of the real value of this parameter.

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