Systematic review and meta‐analysis of the association between paediatric obesity and telomere length

2021 ◽  
Author(s):  
Li Lin ◽  
Kang Qin ◽  
Dezhong Chen ◽  
Ciyong Lu ◽  
Weiqing Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Telomere Length ◽  
Meta Analysis ◽  
Paediatric Obesity

scholarly journals Perceived stress and telomere length: A systematic review, meta-analysis, and methodologic considerations for advancing the field

2016 ◽  
Vol 54 ◽  
pp. 158-169 ◽  
Author(s):  
Maya B. Mathur ◽  
Elissa Epel ◽  
Shelley Kind ◽  
Manisha Desai ◽  
Christine G. Parks ◽  
...  
Keyword(s):  
Systematic Review ◽  
Telomere Length ◽  
Perceived Stress ◽  
Meta Analysis

Adverse Birth Outcomes and Birth Telomere Length: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 215 ◽  
pp. 64-74.e6 ◽  
Author(s):  
Zhongzheng Niu ◽  
Karen Li ◽  
Chuanbo Xie ◽  
Xiaozhong Wen
Keyword(s):  
Systematic Review ◽  
Telomere Length ◽  
Birth Outcomes ◽  
Meta Analysis ◽  
Adverse Birth Outcomes

scholarly journals Electronic waste exposure and DNA damage: a systematic review and meta-analysis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ibrahim Issah ◽  
John Arko-Mensah ◽  
Thomas P. Agyekum ◽  
Duah Dwomoh ◽  
Julius N. Fobil
Keyword(s):  
Systematic Review ◽  
Dna Damage ◽  
Telomere Length ◽  
Chromosomal Aberrations ◽  
Electronic Waste ◽  
Meta Analysis ◽  
Waste Recycling ◽  
Tail Moment ◽  
Buccal Cells ◽  
Increased Risk

Abstract Objectives Inappropriate processing and disposal of electronic waste (e-waste) expose workers and surrounding populations to hazardous chemicals, including clastogens and aneugens. Recently, considerable literature has grown around e-waste recycling, associated chemical exposures and intermediate health outcomes, including DNA damage. Micronuclei (MN) frequency has been widely used as a biomarker to investigate DNA damage in human populations exposed to genotoxic agents. We conducted a systematic review of published studies to assess DNA damage in e-waste-exposed populations and performed a meta-analysis to evaluate the association between e-waste exposure and DNA damage. Methods This systematic review with meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement checklist. Articles published in English from January 2000 through December 2020 investigating the associations between e-waste exposure and DNA damage were retrieved from the following three major databases: MEDLINE, ProQuest, and Scopus. Studies that reported the use of MN assay as a biomarker of DNA damage were included for meta-analysis. Studies that also reported other DNA damage biomarkers such as chromosomal aberrations, comet assay biomarkers, 8-hydroxy-2′-deoxyguanosine (8-OHdG), telomere length, apoptosis rate were reported using narrative synthesis. Results A total of 20 publications were included in this review, of which seven studies were within the occupational setting, and the remaining 13 studies were ecological studies. The review found six biomarkers of DNA damage (micronuclei, comets assay parameters (tail length, % tail DNA, tail moment, and olive tail moment), 8-OHdG, telomere length, apoptosis rate and chromosomal aberrations) which were assessed using seven different biological matrices (buccal cells, blood, umbilical cord blood, placenta, urine and semen). Most studies showed elevated levels of DNA damage biomarkers among e-waste exposed populations than in control populations. The most commonly used biomarkers were micronuclei frequency (n=9) in peripheral blood lymphocytes or buccal cells and 8-OHdG (n=7) in urine. The results of the meta-analysis showed that electronic waste recycling has contributed to an increased risk of DNA damage measured using MN frequency with a pooled estimate of the standardized mean difference (SMD) of 2.30 (95% CI: 1.36, 3.24, p<0.001) based on 865 participants. Conclusions Taken together, evidence from this systematic review with meta-analysis suggest that occupational and non-occupational exposure to e-waste processing is associated with increased risk of DNA damage measured through MN assay and other types of DNA damage biomarkers. However, more studies from other developing countries in Africa, Latin America, and South Asia are needed to confirm and increase these results’ generalizability.

scholarly journals Basal cortisol, cortisol reactivity, and telomere length: A systematic review and meta-analysis

2019 ◽  
Vol 103 ◽  
pp. 163-172 ◽  
Author(s):  
Yanping Jiang ◽  
Wendi Da ◽  
Shan Qiao ◽  
Quan Zhang ◽  
Xiaoming Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Telomere Length ◽  
Meta Analysis ◽  
Cortisol Reactivity ◽  
Basal Cortisol

scholarly journals Concurrent aerobic plus resistance exercise versus aerobic exercise alone to improve health outcomes in paediatric obesity: a systematic review and meta-analysis

2016 ◽  
Vol 52 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Antonio García-Hermoso ◽  
Robinson Ramírez-Vélez ◽  
Rodrigo Ramírez-Campillo ◽  
Mark D Peterson ◽  
Vicente Martínez-Vizcaíno
Keyword(s):  
Systematic Review ◽  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Body Mass ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Eligibility Criteria ◽  
Exercise Interventions ◽  
Paediatric Obesity ◽  
Concurrent Exercise

ObjectiveTo determine if the combination of aerobic and resistance exercise is superior to aerobic exercise alone for the health of obese children and adolescents.DesignSystematic review with meta-analysis.Data sourcesComputerised search of 3 databases (MEDLINE, EMBASE, and Cochrane Controlled Trials Registry).Eligibility criteria for selecting studiesStudies that compared the effect of supervised concurrent exercise versus aerobic exercise interventions, with anthropometric and metabolic outcomes in paediatric obesity (6–18 years old). The mean differences (MD) of the parameters from preintervention to postintervention between groups were pooled using a random-effects model.Results12 trials with 555 youths were included in the meta-analysis. Compared with aerobic exercise alone, concurrent exercise resulted in greater reductions in body mass (MD=−2.28 kg), fat mass (MD=−3.49%; and MD=−4.34 kg) and low-density lipoprotein cholesterol (MD=−10.20 mg/dL); as well as greater increases in lean body mass (MD=2.20 kg) and adiponectin level (MD=2.59 μg/mL). Differences were larger for longer term programmes (>24 weeks).SummaryConcurrent aerobic plus resistance exercise improves body composition, metabolic profiles, and inflammatory state in the obese paediatric population.Trial registration numberCRD42016039807.

scholarly journals Gender and telomere length: Systematic review and meta-analysis

2014 ◽  
Vol 51 ◽  
pp. 15-27 ◽  
Author(s):  
Michael Gardner ◽  
David Bann ◽  
Laura Wiley ◽  
Rachel Cooper ◽  
Rebecca Hardy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Telomere Length ◽  
Meta Analysis
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