scholarly journals Balancing selection in Pattern Recognition Receptor signalling pathways is associated with gene function and pleiotropy in a wild rodent

2020 ◽  
Vol 29 (11) ◽  
pp. 1990-2003 ◽  
Author(s):  
Max Lundberg ◽  
Xiuqin Zhong ◽  
Anna Konrad ◽  
Remi‐André Olsen ◽  
Lars Råberg
Keyword(s):  
Pattern Recognition ◽  
Gene Function ◽  
Balancing Selection ◽  
Pattern Recognition Receptor ◽  
Signalling Pathways ◽  
Wild Rodent ◽  
Receptor Signalling ◽  
Recognition Receptor

Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination

2007 ◽  
Vol 35 (6) ◽  
pp. 1501-1503 ◽  
Author(s):  
J. Wales ◽  
E. Andreakos ◽  
M. Feldmann ◽  
B. Foxwell
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Systemic Toxicity ◽  
Pattern Recognition Receptor ◽  
Intracellular Signalling ◽  
Present Review ◽  
Signalling Molecules ◽  
Receptor Signalling ◽  
Intracellular Mediators ◽  
Recognition Receptor

PRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellular signalling networks would allow for greater specificity and reduced systemic toxicity. The present review examines the successes seen with overexpression or repression of PRR signalling molecules.

Visualising pattern recognition receptor signalling

2017 ◽  
Vol 45 (5) ◽  
pp. 1077-1085 ◽  
Author(s):  
Charlotte Macleod ◽  
Clare E. Bryant
Keyword(s):  
Pattern Recognition ◽  
Fluorescent Proteins ◽  
Inflammatory Diseases ◽  
Signalling Pathways ◽  
Receptor Signalling ◽  
Infection Susceptibility ◽  
Single Protein ◽  
Microscopy Techniques ◽  
Disease Understanding ◽  
Recognition Receptor

Signalling by pattern recognition receptors (PRRs) is critical for protecting the host against pathogens. Disruption of these signalling pathways has been implicated in many diseases ranging from infection susceptibility to cancer and autoimmune disease. Understanding how PRRs signal is of critical importance due to their potential as therapeutic targets to ameliorate symptoms of inflammatory diseases. The recent advances in microscopy, such as the discovery of fluorescent proteins and the breaking of the diffraction limit of light, offer a unique opportunity to visualise receptor signalling at a single protein level within living cells. Many different microscopy techniques have been developed and used for dissecting different aspects of PRR signalling pathways. This review will provide an overview of the main microscopy techniques used for dissecting these pathways with a focus on Toll-like receptor and NOD-like receptor signalling.

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