Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease

2015 ◽  
Vol 16 (1) ◽  
pp. 35-50 ◽  
Author(s):  
Xuetao Cao
Keyword(s):  
Pattern Recognition ◽  
Self Regulation ◽  
Pattern Recognition Receptor ◽  
Receptor Signalling ◽  
Health And Disease ◽  
Recognition Receptor

Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination

2007 ◽  
Vol 35 (6) ◽  
pp. 1501-1503 ◽  
Author(s):  
J. Wales ◽  
E. Andreakos ◽  
M. Feldmann ◽  
B. Foxwell
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Systemic Toxicity ◽  
Pattern Recognition Receptor ◽  
Intracellular Signalling ◽  
Present Review ◽  
Signalling Molecules ◽  
Receptor Signalling ◽  
Intracellular Mediators ◽  
Recognition Receptor

PRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellular signalling networks would allow for greater specificity and reduced systemic toxicity. The present review examines the successes seen with overexpression or repression of PRR signalling molecules.

Sign in / Sign up

Export Citation Format

Share Document