Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss

2021 ◽  
Author(s):  
Yanchun Li ◽  
Zhongyang Lu ◽  
Lixia Zhang ◽  
Cameron L. Kirkwood ◽  
Keith L. Kirkwood ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bone Loss ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Acid Sphingomyelinase

High‐Fat Diet‐Induced Metabolic Syndrome Increases Ligature‐Induced Alveolar Bone Loss in Mice

Oral Diseases ◽  
2021 ◽  
Author(s):  
Zhongyang Lu ◽  
Yanchun Li ◽  
Hong Yu ◽  
Maria F. Lopes‐Virella ◽  
Yan Huang
Keyword(s):  
Metabolic Syndrome ◽  
Bone Loss ◽  
High Fat Diet ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
High Fat

Long‐term metabolic syndrome is associated with periodontal pockets and alveolar bone loss

2019 ◽  
Vol 46 (8) ◽  
pp. 799-808 ◽  
Author(s):  
Paula Tegelberg ◽  
Tellervo Tervonen ◽  
Matti Knuuttila ◽  
Jari Jokelainen ◽  
Sirkka Keinänen‐Kiukaanniemi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bone Loss ◽  
Alveolar Bone ◽  
Alveolar Bone Loss

scholarly journals Simvastatin Inhibits LPS-induced Alveolar Bone Loss during Metabolic Syndrome

2013 ◽  
Vol 93 (3) ◽  
pp. 294-299 ◽  
Author(s):  
J. Jin ◽  
E.R. Machado ◽  
H. Yu ◽  
X. Zhang ◽  
Z. Lu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bone Loss ◽  
Alveolar Bone ◽  
Alveolar Bone Loss

Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes

2009 ◽  
Vol 44 (1) ◽  
pp. 43-51 ◽  
Author(s):  
T. Ohnishi ◽  
K. Bandow ◽  
K. Kakimoto ◽  
M. Machigashira ◽  
T. Matsuyama ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Bone Loss ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Metabolic Syndrome Model

EFFECTS OF ALENDRONATE THERAPY ON CYCLOSPORINE INDUCED ALVEOLAR BONE LOSS : A MORPHO-METRIC AND BIO-CHEMICAL STUDY IN RATS

2016 ◽  
Vol 4 (4) ◽  
pp. 947-955
Author(s):  
Sneha R Bhat ◽  
◽  
Aravind R Kudva ◽  
Dhoom S Mehta ◽  
◽  
...  
Keyword(s):  
Bone Loss ◽  
Alveolar Bone ◽  
Chemical Study ◽  
Alveolar Bone Loss

3,4,5-Trihydroxybenzoic acid attenuates ligature-induced periodontal disease in Wistar rats.

2020 ◽  
Vol 19 ◽  
Author(s):  
Ozkan Karatas ◽  
Fikret Gevrek
Keyword(s):  
Bone Loss ◽  
Gallic Acid ◽  
Wistar Rats ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Collagenase Activity ◽  
Osteoblastic Activity ◽  
Cell Counts ◽  
Experimental Periodontitis ◽  
Anti Inflammatory

Background: 3,4,5-Trihydroxybenzoic acid, which is also known as gallic acid, is an anti-inflammatory agent who could provide beneficial effects in preventing periodontal inflammation. The present study aimed to evaluate the anti-inflammatory effects of gallic acid on experimental periodontitis in Wistar rats. Alveolar bone loss, osteoclastic activity, osteoblastic activity, and collagenase activity were also determined. Methods: 32 Wistar rats were used in the present study. Study groups were created as following: Healthy control (C,n=8) group; periodontitis (P,n=8) group; periodontitis and 30 mg/kg gallic acid administered group (G30,n=8); periodontitis and 60 mg/kg gallic acid administered group (G60,n=8). Experimental periodontitis was created by placing 4-0 silk sutures around the mandibular right first molar tooth. Morphological changes in alveolar bone were determined by stereomicroscopic evaluation. Mandibles were undergone histological evaluation. Matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1, bone morphogenetic protein (BMP)-2 expressions, tartrate-resistant acid phosphatase (TRAP) positive osteoclast cells, osteoblast, and inflammatory cell counts were determined. Results: Highest alveolar bone loss was observed in the periodontitis group. Both doses of gallic acid decreased alveolar bone loss compared to the P group. TRAP-positive osteoclast cell counts were higher in the P group, and gallic acid successfully lowered these counts. Osteoblast cells also increased in gallic acid administered groups. Inflammation in the P group was also higher than those of C, G30, and G60 groups supporting the role of gallic acid in preventing inflammation. 30 and 60 mg/kg doses of gallic acid decreased MMP-8 levels and increased TIMP-1 levels. BMP levels increased in gallic acid administered groups, similar to several osteoblasts. Conclusion: Present results revealed an anti-inflammatory effect of gallic acid, which was indicated by decreased alveolar bone loss and collagenase activity and increased osteoblastic activity.

scholarly journals Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tsukasa Tominari ◽  
Ayumi Sanada ◽  
Ryota Ichimaru ◽  
Chiho Matsumoto ◽  
Michiko Hirata ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bone Loss ◽  
Alveolar Bone ◽  
Osteoclast Differentiation ◽  
Lipoteichoic Acid ◽  
Alveolar Bone Loss ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria

AbstractPeriodontitis is an inflammatory disease associated with severe alveolar bone loss and is dominantly induced by lipopolysaccharide from Gram-negative bacteria; however, the role of Gram-positive bacteria in periodontal bone resorption remains unclear. In this study, we examined the effects of lipoteichoic acid (LTA), a major cell-wall factor of Gram-positive bacteria, on the progression of inflammatory alveolar bone loss in a model of periodontitis. In coculture of mouse primary osteoblasts and bone marrow cells, LTA induced osteoclast differentiation in a dose-dependent manner. LTA enhanced the production of PGE2 accompanying the upregulation of the mRNA expression of mPGES-1, COX-2 and RANKL in osteoblasts. The addition of indomethacin effectively blocked the LTA-induced osteoclast differentiation by suppressing the production of PGE2. Using ex vivo organ cultures of mouse alveolar bone, we found that LTA induced alveolar bone resorption and that this was suppressed by indomethacin. In an experimental model of periodontitis, LTA was locally injected into the mouse lower gingiva, and we clearly detected alveolar bone destruction using 3D-μCT. We herein demonstrate a new concept indicating that Gram-positive bacteria in addition to Gram-negative bacteria are associated with the progression of periodontal bone loss.

scholarly journals The Protective Effect of Rhizoma Dioscoreae Extract against Alveolar Bone Loss in Ovariectomized Rats via Regulating Wnt and p38 MAPK Signaling

Nutrients ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 5853-5870 ◽  
Author(s):  
Zhiguo Zhang ◽  
Lihua Xiang ◽  
Dong Bai ◽  
Wenlai Wang ◽  
Yan Li ◽  
...  
Keyword(s):  
Bone Loss ◽  
Protective Effect ◽  
P38 Mapk ◽  
Alveolar Bone ◽  
Mapk Signaling ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats

scholarly journals Probiotics ameliorate alveolar bone loss by regulating gut microbiota

2021 ◽  
Author(s):  
Leming Jia ◽  
Ye Tu ◽  
Xiaoyue Jia ◽  
Qian Du ◽  
Xin Zheng ◽  
...  
Keyword(s):  
Bone Loss ◽  
Gut Microbiota ◽  
Alveolar Bone ◽  
Alveolar Bone Loss
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