scholarly journals The Protective Effect of Rhizoma Dioscoreae Extract against Alveolar Bone Loss in Ovariectomized Rats via Regulating Wnt and p38 MAPK Signaling

Nutrients ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 5853-5870 ◽  
Author(s):  
Zhiguo Zhang ◽  
Lihua Xiang ◽  
Dong Bai ◽  
Wenlai Wang ◽  
Yan Li ◽  
...  
Keyword(s):  
Bone Loss ◽  
Protective Effect ◽  
P38 Mapk ◽  
Alveolar Bone ◽  
Mapk Signaling ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats

scholarly journals Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling

2017 ◽  
Vol 40 (5) ◽  
pp. 1602-1610
Author(s):  
Zhi-Guo Zhang ◽  
Yan-Jing Chen ◽  
Li-Hua Xiang ◽  
Jing-Hua Pan ◽  
Zhen Wang ◽  
...  
Keyword(s):  
Bone Loss ◽  
Protective Effect ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats ◽  
Stat3 Signaling

scholarly journals Protective Effect of Resveratrol against the Alveolar Bone Loss in Rats with Experimental Periodontitis and Acts Positively on the IL-17

2021 ◽  
pp. 162-173
Author(s):  
JordanaHeidemann Pandini ◽  
Lais Fernanda Pasqualotto ◽  
Pedro Henrique de Carli Rodrigues ◽  
João Paulo Gonçalves De Paivaa ◽  
Patricia Oehlmeyer Nassar ◽  
...  
Keyword(s):  
Bone Loss ◽  
Protective Effect ◽  
Alveolar Bone ◽  
Experimental Period ◽  
Alveolar Bone Loss ◽  
Control Group ◽  
Interleukin 17 ◽  
Periodontal Tissues ◽  
Male Wistar Rats ◽  
Experimental Periodontitis

The resveratrol is a polyphenol known for its health benefits, which includes the ability to interfere in the osteoblastogenesis, which may foster adverse immunomodulators effects in the host response to periodontal disease. In the present study we evaluated the appearance of periodontal tissues of rats with experimentally induced periodontitis, by using resveratrol. Twenty-four male Wistar rats were used, in which half of the animals received a ligature around the first lower molars, then forming the groups with experimental periodontitis. Next, four groups were created: 1) Control Group (CON); 2) The Ligature Group (LIG); 3) Group Resveratrol (RSV); 4) Ligature-Resveratrol Group (LIG-RSV). The animals of the Resveratrol groups were daily dosed with 10 mg/kg of body weight of polyphenol orally, during four weeks. After 105 days of experimental period, euthanasia was performed. The results showed a significantly lower alveolar bone loss (p<0.05) in animals that received resveratrol, and still, the polyphenol was able to reduce concentration of interleukin 17 (IL-17) in the groups dosed with it. Our conclusion is that dosing rats with experimental periodontitis with resveratrol could cause a protective effect on the alveolar bone loss, in addition to act positively on the IL-17.

FSH Aggravates Periodontitis-related Bone Loss in Ovariectomized Rats

2010 ◽  
Vol 89 (4) ◽  
pp. 366-371 ◽  
Author(s):  
S. Liu ◽  
Y. Cheng ◽  
M. Fan ◽  
D. Chen ◽  
Z. Bian
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Clinical Features ◽  
Alveolar Bone ◽  
Follicle Stimulating Hormone ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats ◽  
Fsh Receptor ◽  
Histochemical Tests ◽  
Experimental Periodontitis

Alveolar bone loss is one of the prominent pathologic and clinical features of periodontitis. Recently, the direct effect of follicle-stimulating hormone (FSH) on bone resorption has been demonstrated. However, the effect of FSH on alveolar bone loss remains unknown. This study tested the hypothesis that FSH would exacerbate periodontitis-related alveolar bone loss. Experimental periodontitis was induced in ovariectomized rats, and the rats were treated with extrinsic FSH or its inhibitor, leuprorelin. After mandibles were collected, we performed morphological examinations to evaluate bone loss, enzyme histochemical tests for osteoclasts, and immunohistochemical examinations for FSH receptor (FSHR). The results showed that FSH significantly increased alveolar bone resorption compared with non-FSH-treated ovariectomized rats (P < 0.05), and the number of FSHR-positive cells was positively correlated with alveolar bone loss area (r = 0.682, P < 0.01). Our results suggested that FSH can aggravate alveolar bone loss by FSHR, independent of estrogen.

scholarly journals Estrogen deficiency and periodontal condition in rats: a radiographic and macroscopic study

2006 ◽  
Vol 17 (3) ◽  
pp. 201-207 ◽  
Author(s):  
Ana Lia Anbinder ◽  
Marcela de Almeida Prado ◽  
Marianne Spalding ◽  
Ivan Balducci ◽  
Yasmin Rodarte Carvalho ◽  
...  
Keyword(s):  
Risk Factor ◽  
Bone Loss ◽  
Periodontal Disease ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Estrogen Deficiency ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Furcation Involvement ◽  
The Impact

The purpose of this study was to evaluate the impact of ovariectomy-induced estrogen deficiency as a risk factor of periodontal disease in rats. Forty 90-day old female rats were either ovariectomized (OVX; n=20) or sham operated (SHAM; n=20). After 30 days, periodontitis was induced by placement of a cotton ligature around the upper second molars of 10 OVX and 10 SHAM animals. All animals were sacrificed 5 weeks later. Body weight was assessed before all surgical procedures. The left hemimaxillas were removed and the percentage of periodontal bone support was determined radiographically and buccal alveolar bone loss was determined macroscopically using an image-analysis software. Furcation involvement was also evaluated. Data were analyzed statistically by ANOVA at 5% significance level. Within the evaluated period, the ovariectomized rats gained more weight than the sham-operated animals (p<0.001). The animals in which periodontitis was induced had less bone support, greater alveolar bone loss and furcation involvement than those without ligature (p<0.001). However, there was no difference between ovariectomized and sham-operated animals (p>0.05). Based on the findings of this study, estrogen deficiency could not be considered as a risk factor for periodontal disease.

scholarly journals Rhizoma Dioscoreae Extract Protects against Alveolar Bone Loss in Ovariectomized Rats via microRNAs Regulation

Nutrients ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 1333-1351 ◽  
Author(s):  
Zhiguo Zhang ◽  
Changheng Song ◽  
Fangzhen Zhang ◽  
Lihua Xiang ◽  
Yanjing Chen ◽  
...  
Keyword(s):  
Bone Loss ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats
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