Changes in the avascular area of the meniscus using mesenchymal stem cells and growth plate chondrocytes in a pig model

2021 ◽  
Author(s):  
Ryszard Tomaszewski ◽  
Magdalena Rost‐Roszkowska ◽  
Grażyna Wilczek ◽  
Artur Gap ◽  
Łukasz Wiktor
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Plate ◽  
Pig Model ◽  
Growth Plate Chondrocytes ◽  
Avascular Area

Characterisation of ovine bone marrow derived mesenchymal stem cells and autologous application to growth plate cartilage defect

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S159
Author(s):  
R.C. McCarty ◽  
S. Gronthos ◽  
A.C. Zannettino ◽  
B.K. Foster ◽  
C.J. Xian
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Growth Plate ◽  
Cartilage Defect ◽  
Growth Plate Cartilage

Human Umbilical Cord Mesenchymal Stem Cells Alleviate Nasal Mucosa Radiation Damage in a Guinea Pig Model

2014 ◽  
Vol 116 (2) ◽  
pp. 331-338 ◽  
Author(s):  
Hong-Gang Duan ◽  
Fang Ji ◽  
Chun-Quan Zheng ◽  
Chun-Hua Wang ◽  
Jing Li
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Guinea Pig ◽  
Radiation Damage ◽  
Umbilical Cord ◽  
Nasal Mucosa ◽  
Pig Model ◽  
Human Umbilical Cord ◽  
Guinea Pig Model

scholarly journals Nanotechnology and mesenchymal stem cells with chondrocytes in prevention of partial growth plate arrest in pigs

2012 ◽  
Vol 156 (2) ◽  
pp. 128-134 ◽  
Author(s):  
Ladislav Planka ◽  
Robert Srnec ◽  
Petr Rauser ◽  
David Stary ◽  
Eva Filova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Plate

scholarly journals Mesenchymal stem cells correct haemodynamic dysfunction associated with liver injury after extended resection in a pig model

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hans-Michael Tautenhahn ◽  
Sandra Brückner ◽  
Christiane Uder ◽  
Silvio Erler ◽  
Madlen Hempel ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Injury ◽  
Pig Model ◽  
Extended Resection

Localization of Exogenous Mesenchymal Stem Cells in a Pig Model of Lung Transplantation

2017 ◽  
Vol 66 (01) ◽  
pp. 063-070 ◽  
Author(s):  
Tanja Piatkowski ◽  
Christina Brandenberger ◽  
Parwis Rahmanian ◽  
Yeong-Hoon Choi ◽  
Mohamed Zeriouh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lung Transplantation ◽  
Left Lung ◽  
Microscopic Analysis ◽  
Pig Model ◽  
Homogeneous Distribution ◽  
Heterogeneous Distribution ◽  
Administration Routes ◽  
The Right

Background Mesenchymal stem cells (MSCs) have a great potential for the treatment of acute lung injury. This study provides a detailed immunohistochemical and stereological analysis of the localization and distribution of exogenous MSC in a pig model of lung transplantation after intravascular or endobronchial application. Methods MSC derived from human bone marrow were labeled by DiI and administered intravascularly or endobronchially to the lungs of donor pigs after a period of 3 hours warm and 3 hours cold ischemia. The left lung was transplanted to a recipient pig and reperfused for 4 hours before fixation. The right donor lung was fixed for microscopic analysis directly after the ischemia time. Results After both administration routes, a similar number of exogenous MSC was found in the lungs. Within each animal, the heterogeneity of MSC distribution was high both with respect to left and right lung as well as to the different lobes of each lung. After endobronchial application, MSC were found in alveolar and bronchial/bronchiolar lumen, whereas after intravascular administration, they were mainly observed in blood vessels. Conclusion Although the administration of exogenous MSC is possible by endobronchial or intravascular application, it yields a heterogeneous distribution in the lungs which may warrant strategies to improve a more homogeneous distribution.

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