scholarly journals Retracted: Exogenous IL-4-Expressing Bone Marrow Mesenchymal Stem Cells for the Treatment of Autoimmune Sensorineural Hearing Loss in a Guinea Pig Model

2017 ◽  
Vol 2017 ◽  
pp. 1-1 ◽  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Hearing Loss ◽  
Guinea Pig ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Pig Model ◽  
Marrow Mesenchymal Stem Cells ◽  
Guinea Pig Model

scholarly journals Exogenous IL-4-Expressing Bone Marrow Mesenchymal Stem Cells for the Treatment of Autoimmune Sensorineural Hearing Loss in a Guinea Pig Model

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Chang-qiang Tan ◽  
Xia Gao ◽  
Lang Guo ◽  
He Huang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inner Ear ◽  
Sensorineural Hearing ◽  
Scala Tympani ◽  
Auditory Brain Stem Response ◽  
Marrow Mesenchymal Stem Cells

Bone marrow mesenchymal stem cells (BMSCs) expressing recombinant IL-4 have the potential to remediate inflammatory diseases. We thus investigated whether BMSCs expressing exogenous IL-4 could alleviate autoimmune sensorineural hearing loss. BMSCs isolated from guinea pigs were transfected with recombinant lentivirus expressing IL-4. A total of 33 animals were divided into three groups. Group A received scala tympani injection of IL-4-expressing BMSCs, and Group B received control vector-expressing BMSCs, and Group C received phosphate-buffered saline. The distribution of implanted BMSCs in the inner ears was assessed by immunohistochemistry and fluorescence microscopy. Auditory brain-stem response (ABR) was monitored to evaluate the auditory changes. Following BMSCs transplantation, the threshold levels of ABR wave III decreased in Groups A and B and significant differences were observed between these two groupsP<0.05. Transplanted BMSCs distributed in the scala tympani and scala vestibuli. In some ears with hearing loss, there was a decrease in the number of spiral ganglion cells and varying degrees of endolymphatic hydrops or floccule. Following transplantation, the lentivirus-infected BMSCs migrated to the inner ear and produced IL-4. Our results demonstrate that, upon transplantation, BMSCs and BMSCs expressing recombinant IL-4 have the ability to remediate the inflammatory injury in autoimmune inner ear diseases.

scholarly journals Development of Cytomegalovirus-Mediated Sensorineural Hearing Loss in a Guinea Pig Model

2010 ◽  
Vol 136 (1) ◽  
pp. 48 ◽  
Author(s):  
Albert H. Park ◽  
Thomas Gifford ◽  
Mark R. Schleiss ◽  
Lisa Dahlstrom ◽  
Shane Chase ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Pig Model ◽  
Guinea Pig Model

scholarly journals Therapeutic Efficacy of Bone Marrow Derived Mesenchymal Stem Cells in Ototoxic Sensorineural Hearing Loss

2020 ◽  
Vol 63 (12) ◽  
pp. 564-569
Author(s):  
Subin Kim ◽  
Yoon Hee Kwon ◽  
In Beom Kim ◽  
Young Jun Seo ◽  
Jae Sang Han ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Hearing Loss ◽  
Stem Cell ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Control Group ◽  
Clinical Grade ◽  
Brainstem Response

Background and Objectives Ototoxic sensorineural hearing loss causes permanent hearing loss in most cases. Recently there have been many reports describing cell base therapy with stem cells that has some effect on hearing recovery. We evaluated the efficacy of clinical grade, pre-made, human bone marrow derived mesenchymal stem cells (BM-MSCs) in ototoxic deaf animal model.Materials and Method BM-MSCs were cultured in a clinical grade laboratory. The animals were divided into 2 groups as follows: a saline injected control group and a stem cell injected group (MSC-group). Cultured MSCs were transplanted into the brachial vein of the deaf mice model. We recorded auditory brainstem response (ABR) and conducted immunohistochemistry at 1, 3, and 5 weeks.Results After the transplantation of MSC, a significant improvement in the hearing threshold of ABR was observed in the MSC transplanted group. Five weeks after transplantation of MSCs, hair cell regeneration was confirmed from the basal to the apex of the cochlea in fluorescent dyed image under the microscope compared to the control group.Conclusion BM-MSCs were effective in an acute ototoxic deaf animal model. These results show that stem cell transplantation mediate inner ear regeneration.

Harderian gland-derived stem cells as a cytotherapy in a guinea pig model of carboplatin-induced hearing loss

2019 ◽  
Vol 98 ◽  
pp. 139-152
Author(s):  
Hoda H. Hussein Abd El Raouf ◽  
Rania A. Galhom ◽  
Mona H. Mohammed Ali ◽  
Wael Amin Nasr El-Din
Keyword(s):  
Stem Cells ◽  
Hearing Loss ◽  
Guinea Pig ◽  
Harderian Gland ◽  
Pig Model ◽  
Guinea Pig Model

scholarly journals Mesenchymal stem cells for sensorineural hearing loss: protocol for a systematic review of preclinical studies

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Kevin T. Chorath ◽  
Matthew J. Willis ◽  
Nicolas Morton-Gonzaba ◽  
Walter J. Humann ◽  
Alvaro Moreira
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Preclinical Studies

Human Umbilical Cord Mesenchymal Stem Cells Alleviate Nasal Mucosa Radiation Damage in a Guinea Pig Model

2014 ◽  
Vol 116 (2) ◽  
pp. 331-338 ◽  
Author(s):  
Hong-Gang Duan ◽  
Fang Ji ◽  
Chun-Quan Zheng ◽  
Chun-Hua Wang ◽  
Jing Li
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Guinea Pig ◽  
Radiation Damage ◽  
Umbilical Cord ◽  
Nasal Mucosa ◽  
Pig Model ◽  
Human Umbilical Cord ◽  
Guinea Pig Model
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