scholarly journals High-affinity glutamate transporters in chronic pain: an emerging therapeutic target

2014 ◽  
Vol 131 (6) ◽  
pp. 712-730 ◽  
Author(s):  
Georgi Gegelashvili ◽  
Ole J. Bjerrum
Keyword(s):  
Chronic Pain ◽  
Therapeutic Target ◽  
Glutamate Transporters ◽  
High Affinity

Differentiation of Substrate and Nonsubstrate Inhibitors of the High-Affinity, Sodium-Dependent Glutamate Transporters

1999 ◽  
Vol 56 (6) ◽  
pp. 1095-1104 ◽  
Author(s):  
Hans P. Koch ◽  
Michael P. Kavanaugh ◽  
Christopher S. Esslinger ◽  
Noah Zerangue ◽  
John M. Humphrey ◽  
...  
Keyword(s):  
Glutamate Transporters ◽  
High Affinity ◽  
Sodium Dependent

scholarly journals Sleep spindles as a diagnostic and therapeutic target for chronic pain

2020 ◽  
Vol 16 ◽  
pp. 174480692090235
Author(s):  
Bassir Caravan ◽  
Lizbeth Hu ◽  
Daniel Veyg ◽  
Prathamesh Kulkarni ◽  
Qiaosheng Zhang ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Therapeutic Target ◽  
Sleep Spindles

scholarly journals Something Else Going On? Diagnostic Uncertainty in Children with Chronic Pain and Their Parents

Children ◽  
2020 ◽  
Vol 7 (10) ◽  
pp. 165
Author(s):  
Vivek Tanna ◽  
Lauren C. Heathcote ◽  
Marissa S. Heirich ◽  
Gillian Rush ◽  
Alexandra Neville ◽  
...  
Keyword(s):  
United States ◽  
Chronic Pain ◽  
Risk Factor ◽  
Health Problem ◽  
Therapeutic Target ◽  
The United States ◽  
Pain Clinic ◽  
Diagnostic Uncertainty ◽  
Pediatric Chronic Pain ◽  
Lower Pain

Diagnostic uncertainty, the perceived lack of an accurate explanation of the patient’s health problem, remains relatively unstudied in children. This study examined the prevalence, familial concordance, and correlates of diagnostic uncertainty in children and their parents presenting to a multidisciplinary pain clinic in the United States. One hundred and twenty-six parents and 91 of their children (Mage = 13.93 years, range = 8–18 years) completed a brief three-item measure of diagnostic uncertainty, as well as measures of pain-related distress and functioning. Forty-eight percent of children and 37% of parents believed something else was going on with the child’s pain that doctors had not found out about yet. Across the three items, 66%–77% of children and their parents agreed in their endorsement of diagnostic uncertainty. Parents who believed that something else was going on with their child’s pain had children with higher avoidance of pain-related activities (F = 5.601, p = 0.020) and lower pain willingness (F = 4.782, p = 0.032). Neither parent nor child diagnostic uncertainty was significantly related to the child’s pain-related functioning. Diagnostic uncertainty, particularly in parents, is relevant in the experience of pediatric chronic pain and warrants further investigation as both a risk factor and therapeutic target.

Neuronal High-Affinity Sodium-Dependent Glutamate Transporters (EAATs): Targets for the Development of Novel Therapeutics Against Neurodegenerative Diseases

2003 ◽  
Vol 9 (8) ◽  
pp. 599-625 ◽  
Author(s):  
Giuseppe Campiani ◽  
Caterina Fattorusso ◽  
Meri Angelis ◽  
Bruno Catalanotti ◽  
Stefania Butini ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Glutamate Transporters ◽  
Novel Therapeutics ◽  
High Affinity ◽  
Sodium Dependent
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