scholarly journals Hearing Impairment and Physical Function and Falls in the Atherosclerosis Risk in Communities Hearing Pilot Study

2016 ◽  
Vol 64 (4) ◽  
pp. 906-908 ◽  
Author(s):  
Jennifer A. Deal ◽  
A. Richey Sharrett ◽  
Karen Bandeen-Roche ◽  
Stephen B. Kritchevsky ◽  
Lisa A. Pompeii ◽  
...  
Keyword(s):  
Pilot Study ◽  
Physical Function ◽  
Hearing Impairment ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

scholarly journals Hearing Impairment and Cognitive Decline: A Pilot Study Conducted Within the Atherosclerosis Risk in Communities Neurocognitive Study

2015 ◽  
Vol 181 (9) ◽  
pp. 680-690 ◽  
Author(s):  
Jennifer A. Deal ◽  
A. Richey Sharrett ◽  
Marilyn S. Albert ◽  
Josef Coresh ◽  
Thomas H. Mosley ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cognitive Decline ◽  
Hearing Impairment ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

scholarly journals Relationship of hearing impairment with MRI brain volumes and cognitive decline in the Atherosclerosis Risk in Communities study

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Jennifer A Deal ◽  
Melinda C Power ◽  
Joshua Betz ◽  
Nicholas S Reed ◽  
Marilyn S Albert ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Hearing Impairment ◽  
Brain Volumes ◽  
Atherosclerosis Risk In Communities ◽  
Mri Brain ◽  
Atherosclerosis Risk ◽  
Relationship Of

scholarly journals Sphingolipids and physical function in the Atherosclerosis Risk in Communities (ARIC) study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Danni Li ◽  
Aniqa B. Alam ◽  
Fang Yu ◽  
Anna Kucharska-Newton ◽  
B. Gwen Windham ◽  
...  
Keyword(s):  
Physical Function ◽  
Walking Speed ◽  
Plasma Concentrations ◽  
P Value ◽  
Cross Sectional ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
The Stability ◽  
Aric Study ◽  
Long Chain

AbstractLong-chain sphingomyelins (SMs) may play an important role in the stability of myelin sheath underlying physical function. The objective of this study was to examine the cross-sectional and longitudinal associations of long-chain SMs [SM (41:1), SM (41:2), SM (43:1)] and ceramides [Cer (41:1) and Cer (43:1)] with physical function in the Atherosclerosis Risk in Communities (ARIC) study. Plasma concentrations of SM (41:1), SM (41:2), SM (43:1), Cer (41:1) and Cer (43:1) were measured in 389 ARIC participants in 2011–13. Physical function was assessed by grip strength, Short Physical Performance Battery (SPPB), 4-m walking speed at both 2011–13 and 2016–17, and the modified Rosow-Breslau questionnaire in 2016–2017. Multivariable linear and logistic regression analyses were performed, controlling for demographic and clinical confounders. In cross-sectional analyses, plasma concentrations of SM 41:1 were positively associated with SPPB score (β-coefficients [95% confidence internal]: 0.33 [0.02, 0.63] per 1 standard deviation [SD] increase in log-transformed concentration, p value 0.04), 4-m walking speed (0.042 m/s [0.01, 0.07], p value 0.003), and negatively with self-reported disability (odds ratio = 0.73 [0.65, 0.82], p value < 0.0001). Plasma concentrations of the five metabolites examined were not significantly associated with longitudinal changes in physical function or incidence of poor mobility. In older adults, plasma concentrations of long-chain SM 41:1 were cross-sectionally positively associated with physical function.

scholarly journals Plasma Metabolites Associated with Brain MRI Measures of Neurodegeneration in Older Adults in the Atherosclerosis Risk in Communities–Neurocognitive Study (ARIC-NCS)

2019 ◽  
Vol 20 (7) ◽  
pp. 1744
Author(s):  
Danni Li ◽  
Jeffrey Misialek ◽  
Clifford Jack ◽  
Michelle Mielke ◽  
David Knopman ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Function ◽  
Brain Volume ◽  
Brain Mri ◽  
Plasma Metabolites ◽  
Total Brain Volume ◽  
Atherosclerosis Risk In Communities ◽  
Mri Features ◽  
Total Brain ◽  
Atherosclerosis Risk

Background: Plasma metabolites are associated with cognitive and physical function in the elderly. Because cerebral small vessel disease (SVD) and neurodegeneration are common causes of cognitive and physical function decline, the primary objective of this study was to investigate the associations of six plasma metabolites (two plasma phosphatidylcholines [PCs]: PC aa C36:5 and PC aa 36:6 and four sphingomyelins [SMs]: SM C26:0, SM [OH] C22:1, SM [OH] C22:2, SM [OH] C24:1) with magnetic resonance imaging (MRI) features of cerebral SVD and neurodegeneration in older adults. Methods: This study included 238 older adults in the Atherosclerosis Risk in Communities study at the fifth exam. Multiple linear regression was used to assess the association of each metabolite (log-transformed) in separate models with MRI measures except lacunar infarcts, for which binary logistic regression was used. Results: Higher concentrations of plasma PC aa C36:5 had adverse associations with MRI features of cerebral SVD (odds ratio of 1.69 [95% confidence interval: 1.01, 2.83] with lacunar infarct, and beta of 0.16 log [cm3] [0.02, 0.30] with log [White Matter Hyperintensities (WMH) volume]) while higher concentrations of 3 plasma SM (OH)s were associated with higher total brain volume (beta of 12.0 cm3 [5.5, 18.6], 11.8 cm3 [5.0, 18.6], and 7.3 cm3 [1.2, 13.5] for SM [OH] C22:1, SM [OH] C22:2, and SM [OH] C24:1, respectively). Conclusions: This study identified associations between certain plasma metabolites and brain MRI measures of SVD and neurodegeneration in older adults, particularly higher SM (OH) concentrations with higher total brain volume.

scholarly journals The Association Between Hearing and Physical Functioning in the Atherosclerosis Risk in Communities Study

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 531-531
Author(s):  
Pablo Martinez-Amezcua ◽  
Pei-Lun Kuo ◽  
Kevin Sullivan ◽  
Priya Palta ◽  
A Richey Sharrett ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Physical Function ◽  
Physical Functioning ◽  
Gait Speed ◽  
Negative Impact ◽  
Reference Group ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

Abstract Hearing loss is highly prevalent among older adults and has deleterious effects on health. However, its association with physical functioning is not well defined. We investigated the cross-sectional association between hearing and physical function in 3,339 community-dwelling participants (mean age: 79 years, 59% women) of the Atherosclerosis Risk in Communities Study (ARIC). Hearing was measured by pure-tone average ([dB]) of 4 frequencies [0.5,1,2,4 kHz] and physical function was measured using the short physical performance battery (SPPB), which consisted of 3 performance-based tests (balance, gait speed, and chair stands) each scored ranging from 0-4, resulting in a total possible score of 0-12 (higher scores indicating better physical function). We estimated the association between hearing and physical function using continuous scores for each component of the battery, and the overall SPPB score categorized into high [10-12], intermediate [7-9], and low [≤6]) using ordinal logistic regression models. The SPPB scores were reversed for an easier interpretation of the odds ratios (OR). The category with better physical functions was the reference group for each model. After adjustment for demographics and comorbidities, poorer hearing (+10 dB in PTA) was associated with worse physical functioning: OR for lower balance score=1.17, 95% CI [1.08, 1.26]; OR for lower gait speed score=1.15, 95%CI [1.06, 1.25]; OR for lower chair stand score=1.07, 95% CI [1.04, 1.11]; and OR for lower overall SPPB category=1.15, 95%CI [1.07, 1.24]. Hearing loss is associated with poorer physical functioning, highlighting the potentially negative impact of hearing loss on mobility at older ages.

scholarly journals Relationship Between Domain-Specific Cognitive Function and Speech-in-Noise Performance in Older Adults: The Atherosclerosis Risk in Communities Hearing Pilot Study

2019 ◽  
Vol 28 (4) ◽  
pp. 1006-1014 ◽  
Author(s):  
Sara K. Mamo ◽  
Nicholas S. Reed ◽  
A. Richey Sharrett ◽  
Marilyn S. Albert ◽  
Josef Coresh ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Pilot Study ◽  
Cognitive Status ◽  
Noise Performance ◽  
Atherosclerosis Risk In Communities ◽  
Aural Rehabilitation ◽  
Domain Specific ◽  
Speech In Noise ◽  
Atherosclerosis Risk

Purpose The purpose of this study was to investigate associations between performance on a clinical speech-in-noise measure with a comprehensive neurocognitive battery of tests. Method A group of older adults ( N = 250, M age = 77 years, age range: 67.3–89.1 years) enrolled in the Atherosclerosis Risk in Communities Neurocognitive Study took part in the hearing pilot study (2013) that included testing for audiometric thresholds and speech-in-noise performance (Quick Speech-in-Noise Test; Killion, Niquette, Gudmundsen, Revit, & Banerjee, 2004). This research study analyzed the associations between domain-specific cognitive function and speech-in-noise performance after adjusting for hearing thresholds and other demographic and cardiovascular factors. Results Multivariable-adjusted associations were found between all cognitive domains and speech-in-noise performance in the full sample, but the observed associations varied when participants with varying levels of moderate to moderately severe hearing loss were excluded from the analysis. Conclusions The findings are discussed in terms considering the cognitive status of older adults in relation to their speech-in-noise performance during audiological evaluation and implications for aural rehabilitation.

Abstract P303: Clinically Recognized Varicose Veins and Physical Function in Older Individuals: The Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2019 ◽  
Vol 139 (Suppl_1) ◽  
Author(s):  
Yejin Mok ◽  
Junichi Ishigami ◽  
Anna Kucharska-Newton ◽  
Maya Salameh ◽  
Jennifer Schrack ◽  
...  
Keyword(s):  
Physical Function ◽  
Varicose Veins ◽  
Older Individuals ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

scholarly journals Ankle-brachial index and physical function in older individuals: The Atherosclerosis Risk in Communities (ARIC) study

2017 ◽  
Vol 257 ◽  
pp. 208-215 ◽  
Author(s):  
Kunihiro Matsushita ◽  
Shoshana H. Ballew ◽  
Yingying Sang ◽  
Corey Kalbaugh ◽  
Laura R. Loehr ◽  
...  
Keyword(s):  
Physical Function ◽  
Ankle Brachial Index ◽  
Older Individuals ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study
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