scholarly journals Relationship of hearing impairment with MRI brain volumes and cognitive decline in the Atherosclerosis Risk in Communities study

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Jennifer A Deal ◽  
Melinda C Power ◽  
Joshua Betz ◽  
Nicholas S Reed ◽  
Marilyn S Albert ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Hearing Impairment ◽  
Brain Volumes ◽  
Atherosclerosis Risk In Communities ◽  
Mri Brain ◽  
Atherosclerosis Risk ◽  
Relationship Of

scholarly journals Hearing Impairment and Cognitive Decline: A Pilot Study Conducted Within the Atherosclerosis Risk in Communities Neurocognitive Study

2015 ◽  
Vol 181 (9) ◽  
pp. 680-690 ◽  
Author(s):  
Jennifer A. Deal ◽  
A. Richey Sharrett ◽  
Marilyn S. Albert ◽  
Josef Coresh ◽  
Thomas H. Mosley ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cognitive Decline ◽  
Hearing Impairment ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

Abstract P123: Prospective Association Between Periodontal Disease And Brain Imaging Markers Of Cerebrovascular And Neurodegenerative Disease: The Atherosclerosis Risk In Communities Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Hamdi S Adam ◽  
Kamakshi Lakshminarayan ◽  
Wendy Wang ◽  
Faye L Norby ◽  
Thomas Mosley ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Brain Aging ◽  
Small Vessel Disease ◽  
Brain Mri ◽  
Standardized Uptake Value ◽  
Tissue Loss ◽  
Total Brain Volume ◽  
Brain Volumes ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

Background: Periodontal disease (PD) is associated positively with neurocognitive outcomes. Few studies have investigated the relationship between PD and indicators of brain aging and vascular changes. Hypothesis: PD is associated with greater cerebral small vessel disease, lower total and regional brain volumes and elevated β-amyloid (Aβ) deposition. Methods: We included 6,793 participants who received full-mouth periodontal examinations and tooth counts at Visit 4 (1996-1998) of the Atherosclerosis Risk in Communities Study. We used a modified 3-level version of the Periodontal Profile Class to categorize PD based on severity and extent of gingival inflammation and tissue loss. Among participants who attended Visit 5 (2011-2013), n=1,306 received a brain MRI and n=248 received a PET scan. Total brain volume, Alzheimer’s disease signature volume, and presence of microhemorrhages and cerebral infarctions were ascertained via 3T MRI; Aβ deposition was assessed from PET. We regressed brain volumes on baseline PD status using weighted multivariable linear regression. Presence of cerebrovascular microhemorrhages, infarctions, or elevated Aβ (standardized uptake value ratio>1.2) were regressed on PD category using logistic models. We examined the interaction between Apolipoprotein E ε4 ( APOE ) allele possession and PD categories on the Aβ outcome. Results: Prevalence of baseline periodontal disease was 73% (959/1306) and 87% (206/248) among the MRI and PET subgroups, respectively. PD was not associated with volumetric brain measures nor microhemorrhages. PD was inversely associated with the odds of subcortical and lacunar infarctions. PD and Aβ were not associated in main effect or interaction analyses, although there was a notably stronger association among carriers of APOE . Conclusion: PD was not associated with altered brain structure, cerebral microhemorrhages or elevated Aβ deposition. Counter to the hypothesis, PD and complete tooth loss were inversely associated with cerebral infarctions.

Abstract P001: Retirement Age And 20-year Cognitive Decline: The Atherosclerosis Risk In Communities Neurocognitive Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Albert Liu ◽  
Mehul D Patel ◽  
Alden L Gross ◽  
Thomas Mosley ◽  
Andreea Rawlings ◽  
...  
Keyword(s):  
Black Women ◽  
Cognitive Decline ◽  
Black Men ◽  
Occupational Status ◽  
White Men ◽  
Men And Women ◽  
Atherosclerosis Risk In Communities ◽  
Status Score ◽  
Lower Baseline ◽  
Atherosclerosis Risk

Background: The effect of retirement on cognitive functioning is not clear. We examined the association between age at retirement, midlife occupation, and cognitive decline in the large Atherosclerosis Risk in Communities (ARIC) biracial community-based cohort. Methods: Retirement status after ARIC visit 4 (1996-98) was reported in annual follow-up questionnaires administered in 1999-2007 (n= 8,426), and classified as occurring before or after age 70. Current or most recent occupation at visit 1 (1987-89) was categorized based on 1980 US census major occupation groups and tertiles of Nam-Powers-Boyd occupational status score (a measure of socioeconomic status of occupations, hereby used as a proxy for occupational complexity). Generalized estimating equation models were used to examine the associations of retirement with trajectories of a global cognitive factor score, assessed in 1990-92 (visit 2), 1996-98 (visit 4) and 2011-2013 (visit 5). Models were a priori stratified by race and sex and adjusted for demographics and comorbidities. To account for attrition, we also performed multiple imputation by chained equations. Results: Retirement before age 70 is associated with higher educational level and higher occupational status score in white men and women, and in black men. We observed associations between retirement before age 70 and lower baseline cognitive scores, as well as slower cognitive decline in white men and women, and in black men (Figure). The results did not change substantially after adjusting for the occupational status score or accounting for attrition. Conclusion: Retirement before age 70 was significantly associated with lower baseline cognitive scores and slower cognitive decline in whites and in black men. The lack of similar associations in black women and the investigation of reasons for the observed associations warrant further research.

scholarly journals Plasma phospholipid very-long-chain SFAs in midlife and 20-year cognitive change in the Atherosclerosis Risk in Communities (ARIC): a cohort study

2020 ◽  
Vol 111 (6) ◽  
pp. 1252-1258
Author(s):  
Danni Li ◽  
Jeffrey R Misialek ◽  
Ma Jing ◽  
Michael Y Tsai ◽  
John H Eckfeldt ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cohort Study ◽  
Cognitive Decline ◽  
Plasma Phospholipid ◽  
Cognitive Change ◽  
Word Recall ◽  
Digit Symbol Substitution Test ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Long Chain

Abstract Background Very-long-chain SFAs (VLSFAs) have recently gained considerable attention as having beneficial effects on health and aging. Objectives The objective of this study was to assess the associations of plasma phospholipid VLSFAs [arachidic acid (20:0), behenic acid (22:0), tricosanoic acid (23:0), and lignoceric acid (24:0)] with 20-y cognitive decline in the Atherosclerosis Risk in Communities (ARIC) participants. Furthermore, this study compared the associations of plasma phospholipid VLSFAs with 5 common groups of fatty acids [i.e., total SFAs, total MUFAs, total ω-3 (n–3) PUFAs, total marine-derived ω-3 PUFAs, total ω-6 PUFAs]. Methods This study used a cohort study design of 3229 ARIC participants enrolled at the Minnesota field center. Fatty acids were measured at visit 1 (1987–1989); and cognition was assessed at visits 2 (1990–1992), 4 (1996–1998), and 5 (2011–2013) using 3 tests: the Delayed Word Recall Test (DWRT), the Digit-Symbol Substitution Test (DSST), and the Word Fluency Test (WFT). Results Higher proportions of plasma phospholipid total VLSFAs and each individual VLSFA were associated with less decline in WFT, a test of verbal fluency. For example, 1 SD higher in total VLSFAs at baseline was associated with 0.057 SD (95% CI: 0.018, 0.096, P = 0.004) less cognitive decline over 20 y as measured by WFT score. None of the 5 common fatty acid groups were associated with change in WFT, but a higher proportion of plasma phospholipid total MUFAs was associated with greater decline in DWRT; higher total ω-6 PUFAs with less decline in DWRT; and higher total ω-3 and total marine-derived ω-3 PUFAs with less decline in DSST. Conclusions This study suggests that higher proportions of plasma phospholipid VLSFAs in midlife may be associated with less 20-y cognitive decline.

scholarly journals Incident Heart Failure and Cognitive Decline: The Atherosclerosis Risk in Communities Study

2017 ◽  
Vol 23 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Jan Bressler ◽  
David S. Knopman ◽  
A. Richey Sharrett ◽  
Rebecca F. Gottesman ◽  
Alan Penman ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cognitive Decline ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Incident Heart Failure
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