scholarly journals Hearing Impairment and Cognitive Decline: A Pilot Study Conducted Within the Atherosclerosis Risk in Communities Neurocognitive Study

2015 ◽  
Vol 181 (9) ◽  
pp. 680-690 ◽  
Author(s):  
Jennifer A. Deal ◽  
A. Richey Sharrett ◽  
Marilyn S. Albert ◽  
Josef Coresh ◽  
Thomas H. Mosley ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cognitive Decline ◽  
Hearing Impairment ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

scholarly journals Relationship of hearing impairment with MRI brain volumes and cognitive decline in the Atherosclerosis Risk in Communities study

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Jennifer A Deal ◽  
Melinda C Power ◽  
Joshua Betz ◽  
Nicholas S Reed ◽  
Marilyn S Albert ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Hearing Impairment ◽  
Brain Volumes ◽  
Atherosclerosis Risk In Communities ◽  
Mri Brain ◽  
Atherosclerosis Risk ◽  
Relationship Of

scholarly journals Hearing Impairment and Physical Function and Falls in the Atherosclerosis Risk in Communities Hearing Pilot Study

2016 ◽  
Vol 64 (4) ◽  
pp. 906-908 ◽  
Author(s):  
Jennifer A. Deal ◽  
A. Richey Sharrett ◽  
Karen Bandeen-Roche ◽  
Stephen B. Kritchevsky ◽  
Lisa A. Pompeii ◽  
...  
Keyword(s):  
Pilot Study ◽  
Physical Function ◽  
Hearing Impairment ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

Abstract P001: Retirement Age And 20-year Cognitive Decline: The Atherosclerosis Risk In Communities Neurocognitive Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Albert Liu ◽  
Mehul D Patel ◽  
Alden L Gross ◽  
Thomas Mosley ◽  
Andreea Rawlings ◽  
...  
Keyword(s):  
Black Women ◽  
Cognitive Decline ◽  
Black Men ◽  
Occupational Status ◽  
White Men ◽  
Men And Women ◽  
Atherosclerosis Risk In Communities ◽  
Status Score ◽  
Lower Baseline ◽  
Atherosclerosis Risk

Background: The effect of retirement on cognitive functioning is not clear. We examined the association between age at retirement, midlife occupation, and cognitive decline in the large Atherosclerosis Risk in Communities (ARIC) biracial community-based cohort. Methods: Retirement status after ARIC visit 4 (1996-98) was reported in annual follow-up questionnaires administered in 1999-2007 (n= 8,426), and classified as occurring before or after age 70. Current or most recent occupation at visit 1 (1987-89) was categorized based on 1980 US census major occupation groups and tertiles of Nam-Powers-Boyd occupational status score (a measure of socioeconomic status of occupations, hereby used as a proxy for occupational complexity). Generalized estimating equation models were used to examine the associations of retirement with trajectories of a global cognitive factor score, assessed in 1990-92 (visit 2), 1996-98 (visit 4) and 2011-2013 (visit 5). Models were a priori stratified by race and sex and adjusted for demographics and comorbidities. To account for attrition, we also performed multiple imputation by chained equations. Results: Retirement before age 70 is associated with higher educational level and higher occupational status score in white men and women, and in black men. We observed associations between retirement before age 70 and lower baseline cognitive scores, as well as slower cognitive decline in white men and women, and in black men (Figure). The results did not change substantially after adjusting for the occupational status score or accounting for attrition. Conclusion: Retirement before age 70 was significantly associated with lower baseline cognitive scores and slower cognitive decline in whites and in black men. The lack of similar associations in black women and the investigation of reasons for the observed associations warrant further research.

scholarly journals Plasma phospholipid very-long-chain SFAs in midlife and 20-year cognitive change in the Atherosclerosis Risk in Communities (ARIC): a cohort study

2020 ◽  
Vol 111 (6) ◽  
pp. 1252-1258
Author(s):  
Danni Li ◽  
Jeffrey R Misialek ◽  
Ma Jing ◽  
Michael Y Tsai ◽  
John H Eckfeldt ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cohort Study ◽  
Cognitive Decline ◽  
Plasma Phospholipid ◽  
Cognitive Change ◽  
Word Recall ◽  
Digit Symbol Substitution Test ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Long Chain

Abstract Background Very-long-chain SFAs (VLSFAs) have recently gained considerable attention as having beneficial effects on health and aging. Objectives The objective of this study was to assess the associations of plasma phospholipid VLSFAs [arachidic acid (20:0), behenic acid (22:0), tricosanoic acid (23:0), and lignoceric acid (24:0)] with 20-y cognitive decline in the Atherosclerosis Risk in Communities (ARIC) participants. Furthermore, this study compared the associations of plasma phospholipid VLSFAs with 5 common groups of fatty acids [i.e., total SFAs, total MUFAs, total ω-3 (n–3) PUFAs, total marine-derived ω-3 PUFAs, total ω-6 PUFAs]. Methods This study used a cohort study design of 3229 ARIC participants enrolled at the Minnesota field center. Fatty acids were measured at visit 1 (1987–1989); and cognition was assessed at visits 2 (1990–1992), 4 (1996–1998), and 5 (2011–2013) using 3 tests: the Delayed Word Recall Test (DWRT), the Digit-Symbol Substitution Test (DSST), and the Word Fluency Test (WFT). Results Higher proportions of plasma phospholipid total VLSFAs and each individual VLSFA were associated with less decline in WFT, a test of verbal fluency. For example, 1 SD higher in total VLSFAs at baseline was associated with 0.057 SD (95% CI: 0.018, 0.096, P = 0.004) less cognitive decline over 20 y as measured by WFT score. None of the 5 common fatty acid groups were associated with change in WFT, but a higher proportion of plasma phospholipid total MUFAs was associated with greater decline in DWRT; higher total ω-6 PUFAs with less decline in DWRT; and higher total ω-3 and total marine-derived ω-3 PUFAs with less decline in DSST. Conclusions This study suggests that higher proportions of plasma phospholipid VLSFAs in midlife may be associated with less 20-y cognitive decline.

scholarly journals Incident Heart Failure and Cognitive Decline: The Atherosclerosis Risk in Communities Study

2017 ◽  
Vol 23 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Jan Bressler ◽  
David S. Knopman ◽  
A. Richey Sharrett ◽  
Rebecca F. Gottesman ◽  
Alan Penman ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cognitive Decline ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Incident Heart Failure

scholarly journals Association of lung function with cognitive decline and dementia: the Atherosclerosis Risk in Communities (ARIC) Study

2011 ◽  
Vol 18 (6) ◽  
pp. 888-898 ◽  
Author(s):  
S. S. Pathan ◽  
R. F. Gottesman ◽  
T. H. Mosley ◽  
D. S. Knopman ◽  
A. R. Sharrett ◽  
...  
Keyword(s):  
Lung Function ◽  
Cognitive Decline ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

scholarly journals Obstructive Sleep Apnea and 15-Year Cognitive Decline: The Atherosclerosis Risk in Communities (ARIC) Study

SLEEP ◽  
2016 ◽  
Vol 39 (2) ◽  
pp. 309-316 ◽  
Author(s):  
Pamela L. Lutsey ◽  
Lindsay G.S. Bengtson ◽  
Naresh M. Punjabi ◽  
Eyal Shahar ◽  
Thomas H. Mosley ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cognitive Decline ◽  
Atherosclerosis Risk In Communities ◽  
Obstructive Sleep ◽  
Atherosclerosis Risk ◽  
Aric Study

scholarly journals n–3 Fatty acids, hypertension and risk of cognitive decline among older adults in the Atherosclerosis Risk in Communities (ARIC) study

2008 ◽  
Vol 11 (1) ◽  
pp. 17-29 ◽  
Author(s):  
May A Beydoun ◽  
Jay S Kaufman ◽  
Philip D Sloane ◽  
Gerardo Heiss ◽  
Joseph Ibrahim
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cognitive Decline ◽  
Screening Tools ◽  
Word Recall ◽  
Plasma Fatty Acid ◽  
Men And Women ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Long Chain

AbstractObjectiveRecent research indicates that n–3 fatty acids can inhibit cognitive decline, perhaps differentially by hypertensive status.DesignWe tested these hypotheses in a prospective cohort study (the Atherosclerosis Risk in Communities). Dietary assessment using a food-frequency questionnaire and plasma fatty acid exposure by gas chromatography were completed in 1987–1989 (visit 1), while cognitive assessment with three screening tools – the Delayed Word Recall Test, the Digit Symbol Substitution Test of the Wechsler Adult Intelligence Scale–Revised and the Word Fluency Test (WFT) – was completed in 1990–1992 (visit 2) and 1996–1998 (visit 4). Regression calibration and simulation extrapolation were used to control for measurement error in dietary exposures.SettingFour US communities – Forsyth County (North Carolina), Jackson (Mississippi), suburbs of Minneapolis (Minnesota) and Washington County (Maryland).SubjectsMen and women aged 50–65 years at visit 1 with complete dietary data (n = 7814); white men and women in same age group in the Minnesota field centre with complete plasma fatty acid data (n = 2251).ResultsFindings indicated that an increase of one standard deviation in dietary long-chain n–3 fatty acids (% of energy intake) and balancing long-chain n−3/n–6 decreased the risk of 6-year cognitive decline in verbal fluency with an odds ratio (95% confidence interval) of 0.79 (0.66–0.95) and 0.81 (0.68–0.96), respectively, among hypertensives. An interaction with hypertensive status was found for dietary long-chain n–3 fatty acids (g day−1) and WFT decline (likelihood ratio test, P = 0.06). This exposure in plasma cholesteryl esters was also protective against WFT decline, particularly among hypertensives (OR = 0.51, P < 0.05).ConclusionOne implication from our study is that diets rich in fatty acids of marine origin should be considered for middle-aged hypertensive subjects. To this end, randomised clinical trials are needed.

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