Associations Between Frailty, Retinal Microvascular Changes, and Cerebral White Matter Abnormalities in Korean Older Adults

2014 ◽  
Vol 62 (11) ◽  
pp. 2209-2210 ◽  
Author(s):  
Hee-Won Jung ◽  
Sun-Wook Kim ◽  
Sol-Ji Yoon ◽  
Jung-Yeon Choi ◽  
Kwang-il Kim ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Cerebral White Matter ◽  
White Matter Abnormalities ◽  
Microvascular Changes

scholarly journals Vascular lesions and functional limitations among older adults: does depression make a difference?

2014 ◽  
Vol 26 (9) ◽  
pp. 1501-1509 ◽  
Author(s):  
Celia F. Hybels ◽  
Carl F. Pieper ◽  
Lawrence R. Landerman ◽  
Martha E. Payne ◽  
David C. Steffens
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
White Matter ◽  
Functional Impairment ◽  
Functional Limitations ◽  
Late Life ◽  
Cognitive Status ◽  
Cerebral White Matter ◽  
Late Life Depression ◽  
Increased Risk

ABSTRACTBackground:The association between disability and depression is complex, with disability well established as a correlate and consequence of late life depression. Studies in community samples report that greater volumes of cerebral white matter hyperintensities (WMHs) seen on brain imaging are linked with functional impairment. These vascular changes are also associated with late life depression, but it is not known if depression is a modifier in the relationship between cerebrovascular changes and functional impairment.Methods:The study sample was 237 older adults diagnosed with major depression and 140 never depressed comparison adults, with both groups assessed at study enrollment. The dependent variable was the number of limitations in basic activities of daily living (ADL), instrumental ADLs, and mobility tasks. The independent variable was the total volume of cerebral white matter lesions or hyperintensities assessed though magnetic resonance imaging.Results:In analyses controlling for age, sex, race, high blood pressure, and cognitive status, a greater volume of WMH was positively associated with the total number of functional limitations as well as the number of mobility limitations among those older adults with late life depression but not among those never depressed, suggesting the association between WMH volume and functional status differs in the presence of late life depression.Conclusions:These findings suggest older patients with both depression and vascular risk factors may be at an increased risk for functional decline, and may benefit from management of both cerebrovascular risk factors and depression.

scholarly journals Reversible Cerebral White Matter Abnormalities in Homocystinuria

2018 ◽  
pp. 115-119 ◽  
Author(s):  
Naila Ismayilova ◽  
Andrew D. MacKinnon ◽  
Helen Mundy ◽  
Penny Fallon
Keyword(s):  
White Matter ◽  
Cerebral White Matter ◽  
White Matter Abnormalities

scholarly journals Cerebral white matter abnormalities and their associations with negative but not positive symptoms of schizophrenia

2014 ◽  
Vol 222 (1-2) ◽  
pp. 52-59 ◽  
Author(s):  
Takeshi Asami ◽  
Sang Hyuk Lee ◽  
Sylvain Bouix ◽  
Yogesh Rathi ◽  
Thomas J. Whitford ◽  
...  
Keyword(s):  
White Matter ◽  
Cerebral White Matter ◽  
Positive Symptoms ◽  
White Matter Abnormalities

scholarly journals The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: Results of a one-year exercise intervention

2012 ◽  
Vol 34 (11) ◽  
pp. 2972-2985 ◽  
Author(s):  
Michelle W. Voss ◽  
Susie Heo ◽  
Ruchika S. Prakash ◽  
Kirk I. Erickson ◽  
Heloisa Alves ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
White Matter ◽  
Aerobic Fitness ◽  
Exercise Intervention ◽  
White Matter Integrity ◽  
Cerebral White Matter ◽  
One Year

Vitamin D and white matter abnormalities in older adults: A quantitative volumetric analysis of brain MRI

2015 ◽  
Vol 63 ◽  
pp. 41-47 ◽  
Author(s):  
Cédric Annweiler ◽  
Robert Bartha ◽  
Spyridon N. Karras ◽  
Jennifer Gautier ◽  
Frédéric Roche ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
White Matter ◽  
Brain Mri ◽  
Volumetric Analysis ◽  
White Matter Abnormalities
Sign in / Sign up

Export Citation Format

Share Document