scholarly journals The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: Results of a one-year exercise intervention

2012 ◽  
Vol 34 (11) ◽  
pp. 2972-2985 ◽  
Author(s):  
Michelle W. Voss ◽  
Susie Heo ◽  
Ruchika S. Prakash ◽  
Kirk I. Erickson ◽  
Heloisa Alves ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
White Matter ◽  
Aerobic Fitness ◽  
Exercise Intervention ◽  
White Matter Integrity ◽  
Cerebral White Matter ◽  
One Year

Role of Aerobic Fitness and Aging on Cerebral White Matter Integrity

2007 ◽  
Vol 1097 (1) ◽  
pp. 171-174 ◽  
Author(s):  
B. L MARKS ◽  
D. J MADDEN ◽  
B. BUCUR ◽  
J. M PROVENZALE ◽  
L. E WHITE ◽  
...  
Keyword(s):  
White Matter ◽  
Aerobic Fitness ◽  
White Matter Integrity ◽  
Cerebral White Matter

Impact of Aerobic Fitness on Cerebral White Matter Integrity in the Cingulum.

2008 ◽  
Vol 40 (Supplement) ◽  
pp. S299-S300 ◽  
Author(s):  
Bonita L. Marks ◽  
Laurence M. Katz ◽  
Martin Styner ◽  
J. Keith Smith ◽  
Michael Babbitt ◽  
...  
Keyword(s):  
White Matter ◽  
Aerobic Fitness ◽  
White Matter Integrity ◽  
Cerebral White Matter

Arterial Stiffness Is Associated with White Matter Disruption and Cognitive Impairment: A Community-Based Cohort Study

2021 ◽  
Vol 80 (2) ◽  
pp. 567-576
Author(s):  
Fei Han ◽  
Fei-Fei Zhai ◽  
Ming-Li Li ◽  
Li-Xin Zhou ◽  
Jun Ni ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Arterial Stiffness ◽  
Cognitive Decline ◽  
Sex Education ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
White Matter Injury ◽  
White Matter Integrity ◽  
Cross Sectional

Background: Mechanisms through which arterial stiffness impacts cognitive function are crucial for devising better strategies to prevent cognitive decline. Objective: To examine the associations of arterial stiffness with white matter integrity and cognition in community dwellings, and to investigate whether white matter injury was the intermediate of the associations between arterial stiffness and cognition. Methods: This study was a cross-sectional analysis on 952 subjects (aged 55.5±9.1 years) who underwent diffusion tensor imaging and measurement of brachial-ankle pulse wave velocity (baPWV). Both linear regression and tract-based spatial statistics were used to investigate the association between baPWV and white matter integrity. The association between baPWV and global cognitive function, measured as the mini-mental state examination (MMSE) was evaluated. Mediation analysis was performed to assess the influence of white matter integrity on the association of baPWV with MMSE. Results: Increased baPWV was significantly associated with lower mean global fractional anisotropy (β= –0.118, p < 0.001), higher mean diffusivity (β= 0.161, p < 0.001), axial diffusivity (β= 0.160, p < 0.001), and radial diffusivity (β= 0.147, p < 0.001) after adjustment of age, sex, and hypertension, which were measures having a direct effect on arterial stiffness and white matter integrity. After adjustment of age, sex, education, apolipoprotein E ɛ4, cardiovascular risk factors, and brain atrophy, we found an association of increased baPWV with worse performance on MMSE (β= –0.093, p = 0.011). White matter disruption partially mediated the effect of baPWV on MMSE. Conclusion: Arterial stiffness is associated with white matter disruption and cognitive decline. Reduced white matter integrity partially explained the effect of arterial stiffness on cognition.

Pretreatment abnormalities in white matter integrity predict one-year clinical outcome in first episode schizophrenia

2021 ◽  
Vol 228 ◽  
pp. 241-248
Author(s):  
Jiaxin Zeng ◽  
Wenjing Zhang ◽  
Yuan Xiao ◽  
Gui Fu ◽  
Lu Liu ◽  
...  
Keyword(s):  
White Matter ◽  
Clinical Outcome ◽  
White Matter Integrity ◽  
First Episode ◽  
One Year ◽  
First Episode Schizophrenia

scholarly journals Vascular lesions and functional limitations among older adults: does depression make a difference?

2014 ◽  
Vol 26 (9) ◽  
pp. 1501-1509 ◽  
Author(s):  
Celia F. Hybels ◽  
Carl F. Pieper ◽  
Lawrence R. Landerman ◽  
Martha E. Payne ◽  
David C. Steffens
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
White Matter ◽  
Functional Impairment ◽  
Functional Limitations ◽  
Late Life ◽  
Cognitive Status ◽  
Cerebral White Matter ◽  
Late Life Depression ◽  
Increased Risk

ABSTRACTBackground:The association between disability and depression is complex, with disability well established as a correlate and consequence of late life depression. Studies in community samples report that greater volumes of cerebral white matter hyperintensities (WMHs) seen on brain imaging are linked with functional impairment. These vascular changes are also associated with late life depression, but it is not known if depression is a modifier in the relationship between cerebrovascular changes and functional impairment.Methods:The study sample was 237 older adults diagnosed with major depression and 140 never depressed comparison adults, with both groups assessed at study enrollment. The dependent variable was the number of limitations in basic activities of daily living (ADL), instrumental ADLs, and mobility tasks. The independent variable was the total volume of cerebral white matter lesions or hyperintensities assessed though magnetic resonance imaging.Results:In analyses controlling for age, sex, race, high blood pressure, and cognitive status, a greater volume of WMH was positively associated with the total number of functional limitations as well as the number of mobility limitations among those older adults with late life depression but not among those never depressed, suggesting the association between WMH volume and functional status differs in the presence of late life depression.Conclusions:These findings suggest older patients with both depression and vascular risk factors may be at an increased risk for functional decline, and may benefit from management of both cerebrovascular risk factors and depression.

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