Gastrointestinal: Brain metastasis of alpha-fetoprotein producing gastric adenocarcinoma

2012 ◽  
Vol 28 (1) ◽  
pp. 203-203
Author(s):  
H Kuwabara ◽  
M Goto ◽  
M Yuki ◽  
Y Egashira
Keyword(s):  
Brain Metastasis ◽  
Gastric Adenocarcinoma ◽  
Alpha Fetoprotein

scholarly journals Alpha-Fetoprotein-Producing Lung Hepatoid Adenocarcinoma with Brain Metastasis Treated with S-1

2020 ◽  
Vol 13 (3) ◽  
pp. 1552-1559
Author(s):  
Yuki Muroyama ◽  
Hiroyuki Tamiya ◽  
Goh Tanaka ◽  
Wakae Tanaka ◽  
Alexander C. Huang ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Disease Control ◽  
Parietal Lobe ◽  
Laboratory Data ◽  
Stage Iv ◽  
Final Diagnosis ◽  
Alpha Fetoprotein ◽  
Hepatoid Adenocarcinoma ◽  
Clinical Prognosis

Lung hepatoid adenocarcinoma (HAC) is a rare primary lung carcinoma pathologically characterized by hepatocellular carcinoma-like tumor cells, the majority of which produce alpha-fetoprotein (AFP). The clinical prognosis of lung HAC is generally poor, and effective therapeutic regimens for inoperable or recurrent cases have not been established. Here, we report a case of AFP-producing lung HAC with brain metastasis with long-term disease control, treated with the 5-fluorouracil-derived regimen S-1. The patient was a 66-year-old male admitted to the hospital with alexia. Chest X-ray revealed a massive tumor in the left upper lobe, and a head CT scan revealed a metastasis in the left parietal lobe. The laboratory data showed a remarkably elevated AFP level (97,561 ng/mL). Pathological assessment of the resected brain tumor revealed HAC, which was compatible with the lung biopsies. Together with the absence of other metastatic lesions, a final diagnosis of primary lung HAC, stage IV T4N3M1b, was given. The patient first underwent non-small cell lung cancer chemotherapy regimens (carboplatin and paclitaxel as the first line, and pemetrexed as the second line), but had clinical progression. After third-line oral S-1 (tegafur/gimeracil/oteracil) administration, the serum AFP level significantly dropped and the patient achieved long-term disease control without relapse, surviving more than 19 months after disease presentation. The autopsy result was consistent with the diagnosis of primary lung HAC, and immunohistochemical staining was AFP+, glypican 3+, and spalt-like transcription factor 4+. Here, we report the case of a rare primary lung HAC with apparent disease control on S-1 therapy, together with a literature review.

scholarly journals Alpha-Fetoprotein-Producing Nonmetastatic Gastric Adenocarcinoma: A Rare Entity

2013 ◽  
Vol 45 (2) ◽  
pp. 225-227 ◽  
Author(s):  
A. Vivekanandarajah ◽  
J. P. Atallah ◽  
S. Gupta
Keyword(s):  
Gastric Adenocarcinoma ◽  
Alpha Fetoprotein ◽  
Rare Entity

scholarly journals A Case Report of .ALPHA.-fetoprotein Producing Gastric Adenocarcinoma with Portal Venous Thrombosis.

1995 ◽  
Vol 28 (3) ◽  
pp. 704-708 ◽  
Author(s):  
Kenta Kobashi ◽  
Tadashi Horimi ◽  
Tadanori Ishikawa ◽  
Taku Tanaka ◽  
Etsuhiro Uchida
Keyword(s):  
Case Report ◽  
Venous Thrombosis ◽  
Gastric Adenocarcinoma ◽  
Alpha Fetoprotein ◽  
Portal Venous Thrombosis

scholarly journals MicroRNA-200 family members and ZEB2 are associated with brain metastasis in gastric adenocarcinoma

2014 ◽  
Vol 45 (6) ◽  
pp. 2403-2410 ◽  
Author(s):  
YANG-KI MINN ◽  
DA HYE LEE ◽  
WOO JIN HYUNG ◽  
JI EUN KIM ◽  
JUNJEONG CHOI ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Gastric Adenocarcinoma ◽  
Family Members

scholarly journals Alpha-Fetoprotein Producing Gastric Adenocarcinoma in an Elderly Adult

2016 ◽  
Vol 64 (2) ◽  
pp. 449-449
Author(s):  
Hakan Demirci ◽  
Kadir Ozturk ◽  
Murat Kantarcioglu ◽  
Ahmet Uygun ◽  
Sait Bagci
Keyword(s):  
Gastric Adenocarcinoma ◽  
Alpha Fetoprotein ◽  
Elderly Adult

scholarly journals Protein profiling of alpha-fetoprotein producing gastric adenocarcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (19) ◽  
pp. 28448-28459 ◽  
Author(s):  
Liang He ◽  
Fei Ye ◽  
Linlin Qu ◽  
Daguang Wang ◽  
Miao Cui ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Alpha Fetoprotein ◽  
Protein Profiling

Clinical Implications of Alpha-Fetoprotein Expression in Gastric Adenocarcinoma

2003 ◽  
Vol 21 (4) ◽  
pp. 357-362 ◽  
Author(s):  
Jie Chen ◽  
Christoph Röcken ◽  
Gerhard Treiber ◽  
Kathleen Jentsch-Ulrich ◽  
Peter Malfertheiner ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Alpha Fetoprotein ◽  
Clinical Implications
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