Clinical Implications of Alpha-Fetoprotein Expression in Gastric Adenocarcinoma

2003 ◽  
Vol 21 (4) ◽  
pp. 357-362 ◽  
Author(s):  
Jie Chen ◽  
Christoph Röcken ◽  
Gerhard Treiber ◽  
Kathleen Jentsch-Ulrich ◽  
Peter Malfertheiner ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Alpha Fetoprotein ◽  
Clinical Implications

Reactivity of amniotic fluid alpha-fetoprotein with concanavalin A in relation to gestational age: clinical implications.

1980 ◽  
Vol 26 (12) ◽  
pp. 1656-1659 ◽  
Author(s):  
K Toftager-Larsen ◽  
E Kjaersgaard ◽  
J C Jacobsen ◽  
B Nørgaard-Pedersen
Keyword(s):  
Amniotic Fluid ◽  
Clinical Significance ◽  
Concanavalin A ◽  
Gestational Age ◽  
Normal Values ◽  
Alpha Fetoprotein ◽  
Clinical Implications ◽  
Fetal Malformation ◽  
Average Decrease ◽  
Normal Outcome

Abstract We used concanavalin A crossed-line affinity immunoelectrophoresis to determine the percentage of concanavalin A nonreactive alpha-fetoprotein in amniotic fluid samples from pregnancies with normal and abnormal fetuses. In 167 samples from pregnancies with a normal outcome and normal values for total alpha-fetoprotein concentration in amniotic fluid the percentage decreased from a median value of 27.4% in the 13th week to 8.5% in the 21st week of gestation, and a statistically significant (p < 0.001) average decrease of 1.7% per week was found from the 14th to the 19th week. A similar average decrease (2.2%) was found in 22 pregnancies from which two or more samples were obtained. The clinical significance of this decrease is discussed. Of 108 samples from patients with above-normal values for total alpha-fetoprotein and a normal outcome, seven had a total alpha-fetoprotein above recommended cut-off values, and only one of these had a low percentage of concanavalin A nonreactive alpha-fetoprotein. In contrast, for all 27 samples from pregnancies with a severe fetal malformation this percentage was low, even in one case where the total alpha-fetoprotein concentration was below the recommended cut-off value.

scholarly journals Alpha-Fetoprotein-Producing Nonmetastatic Gastric Adenocarcinoma: A Rare Entity

2013 ◽  
Vol 45 (2) ◽  
pp. 225-227 ◽  
Author(s):  
A. Vivekanandarajah ◽  
J. P. Atallah ◽  
S. Gupta
Keyword(s):  
Gastric Adenocarcinoma ◽  
Alpha Fetoprotein ◽  
Rare Entity

scholarly journals A Case Report of .ALPHA.-fetoprotein Producing Gastric Adenocarcinoma with Portal Venous Thrombosis.

1995 ◽  
Vol 28 (3) ◽  
pp. 704-708 ◽  
Author(s):  
Kenta Kobashi ◽  
Tadashi Horimi ◽  
Tadanori Ishikawa ◽  
Taku Tanaka ◽  
Etsuhiro Uchida
Keyword(s):  
Case Report ◽  
Venous Thrombosis ◽  
Gastric Adenocarcinoma ◽  
Alpha Fetoprotein ◽  
Portal Venous Thrombosis

Clinical Implications of Alanine Transaminase Level in the Diagnostic Accuracy of Alpha-Fetoprotein for Predicting Hepatocellular Carcinoma in Patients with Hepatis B Infection

2020 ◽  
Author(s):  
Bo Hu ◽  
Jiahao Chen ◽  
Manli Wu ◽  
Jiao Gong ◽  
Zhihuan Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Transaminase Level ◽  
Alanine Transaminase ◽  
Alpha Fetoprotein ◽  
Clinical Implications ◽  
Gamma Glutamyl Transferase ◽  
Upper Limit ◽  
Glutamyl Transferase ◽  
Better Than

Abstract Background Abnormally elevated AFP level is often observed in patients with chronic hepatitis infections without evident of (hepatocellular carcinoma) HCC. Our study aimed to investigate the influence of alanine transaminase (ALT) on the accuracy of alpha-fetoprotein (AFP) for detecting HCC. Methods This retrospective study recruited 799 patients with HCC, cirrhosis and chronic hepatitis due to hepatitis B infection and healthy adults between July 2017 and January 2019. Comparisons of the area under the receiver-operating curves (AUCs) for detecting HCC in different ALT levels were calculated. Results Serum ALT and gamma-glutamyl transferase level were significantly associated with elevated AFP in patients without HCC. The AUC of AFP was higher in patients with ALT ≤ 2 upper limit of normal (ULN) than in patients with ALT > 2ULN (0.806 vs 0.611, P <0.001). Nevertheless, there was not significant differences in the AUCs of AFP/(ALT×Aspartate aminotransferase(AST) in patients with ALT ≤ 2 ULN and with ALT > 2ULN (0.769 vs 0.769, P = 0.68). AFP/(ALT×AST) was better than AFP in patients with ALT > 2ULN for detecting HCC (P <0.001). Conclusions Higher ALT level might impair the accuracy of AFP for diagnosing HCC. AFP tests showed better accuracy in patients with ALT ≤ 2 ULN whereas AFP/(ALT×AST) ratio was recommended in patients with elevated ALT level.

scholarly journals Clinical Implications of Alpha-fetoprotein in Chronic Hepatitis C

2009 ◽  
Vol 108 (3) ◽  
pp. 210-218 ◽  
Author(s):  
Wei-Chen Tai ◽  
Tsung-Hui Hu ◽  
Jing-Houng Wang ◽  
Chao-Hung Hung ◽  
Sheng-Nan Lu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Alpha Fetoprotein ◽  
Clinical Implications
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