Bioactive compounds of African star apple ( Chrysophyllum albidum G. Don) and its modulatory effect on metabolic activities linked to type 2 diabetes in isolated rat psoas muscle

2020 ◽  
Author(s):  
Ochuko L. Erukainure ◽  
Veronica F. Salau ◽  
Xin Xiao ◽  
Motlalepula G. Matsabisa ◽  
Neil A. Koorbanally ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bioactive Compounds ◽  
Psoas Muscle ◽  
Metabolic Activities ◽  
African Star Apple ◽  
Isolated Rat

scholarly journals The Active Role of Leguminous Plant Components in Type 2 Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Monika Gętek ◽  
Natalia Czech ◽  
Małgorzata Muc-Wierzgoń ◽  
Elżbieta Grochowska-Niedworok ◽  
Teresa Kokot ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bioactive Compounds ◽  
International Diabetes Federation ◽  
Noncommunicable Diseases ◽  
Antidiabetic Activity ◽  
Leguminous Plant ◽  
Morbidity Rate ◽  
Diabetes Incidence ◽  
Leguminous Plants

Diabetes appears to be one of the most frequent noncommunicable diseases in the world. A permanent growth in the incidence of diabetes can be observed and according to the International Diabetes Federation (IDF) the year 2030 will mark the increase in the number of diabetics to 439 mln worldwide. Type 2 diabetes accounts for about 90% of all diabetes incidence. Nutrition model modification not only features the basic element in type 2 diabetes treatment but also constitutes the fundamental factor influencing a morbidity rate decrease. Leguminous plants are a key factor in the diabetic diet; plants such as pulses or soybeans are nutritious products valued highly in nutrition. These legumes are high in the content of wholesome protein and contain large amounts of soluble alimentary fiber fractions, polyunsaturated fatty acids, vitamins and minerals, and bioactive substances with antioxidant, anti-inflammatory, and anticancer activity. They are distinguished by the high amount of bioactive compounds that may interfere with the metabolism of glucose. The most significant bioactive compounds displaying antidiabetic activity in leguminous plants are as follows: genistein and daidzein, alpha-amylase inhibitors, and alpha-glucosidase inhibitors.In vitroresearch using leguminous plant extracts has confirmed their antidiabetic properties. Leguminous plants should be employed in the promotion of healthy lifestyles in terms of functional food.

scholarly journals Molecular docking analysis of compounds from Lycopersicon esculentum with the insulin receptor to combat type 2 diabetes

2020 ◽  
Vol 16 (10) ◽  
pp. 748-752
Author(s):  
Anitha Roy ◽  
Keyword(s):  
Type 2 Diabetes ◽  
Molecular Docking ◽  
Lycopersicon Esculentum ◽  
Insulin Receptor ◽  
Bioactive Compounds ◽  
Insulin Receptors ◽  
Docking Analysis ◽  
Molecular Docking Analysis

It is known that tomato (Lycopersicon esculentum) contains bioactive compounds to combat type-2 diabetes. Therefore, it is of interest to document data from the molecular docking analysis of compounds from Lycopersicon esculentum with the insulin receptors to combat type-2 diabetes. We report the binding features of cinnamicacid, chlorogenicacid, gallicacid & glucoside with insulin receptors for further consideration.

Vanillin improves glucose homeostasis and modulates metabolic activities linked to type 2 diabetes in fructose–streptozotocin induced diabetic rats

2021 ◽  
pp. 1-14
Author(s):  
Veronica F. Salau ◽  
Ochuko L. Erukainure ◽  
Kolawole O. Olofinsan ◽  
Nontokozo Z. Msomi ◽  
Omamuyovwi M. Ijomone ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Homeostasis ◽  
Diabetic Rats ◽  
Metabolic Activities

scholarly journals Nutrigenomics in Regulating the Expression of Genes Related to Type 2 Diabetes Mellitus

2021 ◽  
Vol 12 ◽  
Author(s):  
Karoline Felisbino ◽  
Juliano Gomes Granzotti ◽  
Larissa Bello-Santos ◽  
Izonete Cristina Guiloski
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bioactive Compounds ◽  
Cell Mass ◽  
Expression Of Genes ◽  
Human Genes ◽  
Regular Consumption ◽  
Positive Results

Nutrigenomics is the study of the gene-nutrient interaction and it indicates that some nutrients, called bioactive compounds, can mold the genetic expression or change the nucleotide chain. Polyphenols are secondary metabolites found in plants that are regularly consumed in functional foods and help prevent or delay the onset of type 2 diabetes mellitus (T2DM) and its complications. This article objected to review studies about the interaction of diet with polyphenols and Mediterranean diet in the expression of human genes related to T2DM. Resveratrol acts as an antioxidant, anti-inflammatory, and increases mitochondrial function. Regular consumption of quercetin resulted in improvement of hypertension and suppression of diabetes-induced vasoconstriction. Genistein also showed positive results in T2DM, such as increased cell mass and improved glucose tolerance and insulin levels. Catechins showed efficiency in inducing genes in triacylglycerol biosynthesis, inhibition of fatty acids and cholesterol, and resulting in their participation in mitigating complications of diabetes. Lastly, curcumin was demonstrated to be a protector of the pancreatic islets against streptozotocin-induced oxidative stress. Growing evidence suggest that bioactive compounds such as polyphenols have an important role in T2DM and the prevention and treatment of its complication, as they cause activation or inhibition of related genes.

scholarly journals Algae as a Source of Bioactive Compounds to Prevent the Development of Type 2 Diabetes Mellitus

2021 ◽  
Vol 28 ◽  
Author(s):  
Jelena B. Popović-Djordjević ◽  
Jelena S. Katanić Stanković ◽  
Vladimir Mihailović ◽  
A.G. Pereira ◽  
P. Garcia-Oliveira ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bioactive Compounds ◽  
Raw Materials ◽  
Amyloid Plaques ◽  
Direct Effects ◽  
Beneficial Effects ◽  
Life Habits

: Type 2 diabetes mellitus is a complicated metabolic disorder characterized by hyperglycemia and glucose intolerance. It is considered as a new pandemic whose control is creating numerous challenges. Although many of the measures are based on improving life habits, diet is also of vital importance due to bioactive compounds present in food. In this regard, several raw materials have been investigated whose bioactivities seem to slow the progression of this disease. Within these matrices there are algae of importance, such as brown algae, showing to have beneficial effects on glycemic control. These evidences are increasing every day due to the development of cell or animal models which leads to the conclusion that bioactive compounds may have direct effects on decreasing hyperglycemia, enhancing insulin secretion and preventing formation of amyloid plaques. Type 2 diabetes mellitus is a complicated metabolic disorder characterized by hyperglycemia and glucose intolerance. It is considered as a new pandemic whose control is creating numerous challenges. Although many of the measures are based on improving life habits, diet is also of vital importance due to bioactive compounds present in food. In this regard, several raw materials have been investigated whose bioactivities seem to slow the progression of this disease. Within these matrices there are algae of importance, such as brown algae, showing to have beneficial effects on glycemic control. These evidences are increasing every day due to the development of cell or animal models which leads to the conclusion that bioactive compounds may have direct effects on decreasing hyperglycemia, enhancing insulin secretion and preventing formation of amyloid plaques.

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