scholarly journals Functional and Biological Potential of Bioactive Compounds in Foods for the Dietary Treatment of Type 2 Diabetes Mellitus

2017 ◽  
Author(s):  
Daniel Pelcastre Monjiote ◽  
Edwin E. Martínez Leo ◽  
Maira Rubi Segura Campos
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bioactive Compounds ◽  
Dietary Treatment ◽  
Biological Potential

scholarly journals Nutrigenomics in Regulating the Expression of Genes Related to Type 2 Diabetes Mellitus

2021 ◽  
Vol 12 ◽  
Author(s):  
Karoline Felisbino ◽  
Juliano Gomes Granzotti ◽  
Larissa Bello-Santos ◽  
Izonete Cristina Guiloski
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bioactive Compounds ◽  
Cell Mass ◽  
Expression Of Genes ◽  
Human Genes ◽  
Regular Consumption ◽  
Positive Results

Nutrigenomics is the study of the gene-nutrient interaction and it indicates that some nutrients, called bioactive compounds, can mold the genetic expression or change the nucleotide chain. Polyphenols are secondary metabolites found in plants that are regularly consumed in functional foods and help prevent or delay the onset of type 2 diabetes mellitus (T2DM) and its complications. This article objected to review studies about the interaction of diet with polyphenols and Mediterranean diet in the expression of human genes related to T2DM. Resveratrol acts as an antioxidant, anti-inflammatory, and increases mitochondrial function. Regular consumption of quercetin resulted in improvement of hypertension and suppression of diabetes-induced vasoconstriction. Genistein also showed positive results in T2DM, such as increased cell mass and improved glucose tolerance and insulin levels. Catechins showed efficiency in inducing genes in triacylglycerol biosynthesis, inhibition of fatty acids and cholesterol, and resulting in their participation in mitigating complications of diabetes. Lastly, curcumin was demonstrated to be a protector of the pancreatic islets against streptozotocin-induced oxidative stress. Growing evidence suggest that bioactive compounds such as polyphenols have an important role in T2DM and the prevention and treatment of its complication, as they cause activation or inhibition of related genes.

scholarly journals Ambulatory glucose profile as an educational tool in the management of patients with type 2 diabetes mellitus

2020 ◽  
Vol 8 (2) ◽  
pp. 734
Author(s):  
A. G. Unnikrishnan ◽  
Vedavati Bharat Purandare
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lifestyle Modification ◽  
Glucose Monitoring ◽  
Dietary Treatment ◽  
Postprandial Glucose ◽  
Lifestyle Modifications ◽  
Glucose Profile

A 60-year-old male patient with Type 2 Diabetes Mellitus (T2DM) since the last two years was presented in the clinic with repeated falls. He was on dietary treatment and was also taking metformin 500 mg twice daily, on and off. His Fasting Plasma Glucose (FPG) was 116 mg/dL, Postprandial Glucose (PPG) was 140 mg/dL and Glycosylated Haemoglobin (HbA1c) was 6.4%. The complete glycaemic profile obtained from the first Ambulatory Glucose Profile (AGP) revealed that the patient was not having hypoglycaemia and has very minimal glucose fluctuations without any post-prandial excursions. The visual cue obtained from Continuous Glucose Monitoring (CGM) / AGP enabled physicians to better inform the patient on the effects of medication and lifestyle on diabetes, thereby allowing the patient to make informed treatment and lifestyle modifications. This case study sheds light on the need to recommend AGP in such cases to provide insights on the glucose trends, thereby improve patient’s confidence in the therapy, with lifestyle modification.

Executive summary: Updates to the dietary treatment of prediabetes and type 2 diabetes mellitus

2021 ◽  
Vol 221 (3) ◽  
pp. 169-179
Author(s):  
V. Pascual Fuster ◽  
A. Pérez Pérez ◽  
J. Carretero Gómez ◽  
A. Caixàs Pedragós ◽  
R. Gómez-Huelgas ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Dietary Treatment ◽  
Executive Summary

scholarly journals Algae as a Source of Bioactive Compounds to Prevent the Development of Type 2 Diabetes Mellitus

2021 ◽  
Vol 28 ◽  
Author(s):  
Jelena B. Popović-Djordjević ◽  
Jelena S. Katanić Stanković ◽  
Vladimir Mihailović ◽  
A.G. Pereira ◽  
P. Garcia-Oliveira ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bioactive Compounds ◽  
Raw Materials ◽  
Amyloid Plaques ◽  
Direct Effects ◽  
Beneficial Effects ◽  
Life Habits

: Type 2 diabetes mellitus is a complicated metabolic disorder characterized by hyperglycemia and glucose intolerance. It is considered as a new pandemic whose control is creating numerous challenges. Although many of the measures are based on improving life habits, diet is also of vital importance due to bioactive compounds present in food. In this regard, several raw materials have been investigated whose bioactivities seem to slow the progression of this disease. Within these matrices there are algae of importance, such as brown algae, showing to have beneficial effects on glycemic control. These evidences are increasing every day due to the development of cell or animal models which leads to the conclusion that bioactive compounds may have direct effects on decreasing hyperglycemia, enhancing insulin secretion and preventing formation of amyloid plaques. Type 2 diabetes mellitus is a complicated metabolic disorder characterized by hyperglycemia and glucose intolerance. It is considered as a new pandemic whose control is creating numerous challenges. Although many of the measures are based on improving life habits, diet is also of vital importance due to bioactive compounds present in food. In this regard, several raw materials have been investigated whose bioactivities seem to slow the progression of this disease. Within these matrices there are algae of importance, such as brown algae, showing to have beneficial effects on glycemic control. These evidences are increasing every day due to the development of cell or animal models which leads to the conclusion that bioactive compounds may have direct effects on decreasing hyperglycemia, enhancing insulin secretion and preventing formation of amyloid plaques.

scholarly journals Rice Bran Derived Bioactive Compounds Modulate Risk Factors of Cardiovascular Disease and Type 2 Diabetes Mellitus: An Updated Review

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2736 ◽  
Author(s):  
Nancy Saji ◽  
Nidhish Francis ◽  
Lachlan J. Schwarz ◽  
Christopher L. Blanchard ◽  
Abishek B. Santhakumar
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Diseases ◽  
Bioactive Compounds ◽  
Rice Bran ◽  
Therapeutic Potential

Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) are two chronic diseases that have claimed more lives globally than any other disease. Dietary supplementation of functional foods containing bioactive compounds is recognised to result in improvements in free-radical-mediated oxidative stress. Emerging evidence indicates that bioactive compounds derived from rice bran (RB) have therapeutic potential against cellular oxidative stress. This review aims to describe the mechanistic pathways behind CVD and T2DM development and the therapeutic potential of polyphenols derived from RB against these chronic diseases.

Executive summary: Updates to the dietary treatment of prediabetes and type 2 diabetes mellitus

2021 ◽  
Author(s):  
Vicente Pascual Fuster ◽  
Antonio Pérez Pérez ◽  
Juana Carretero Gómez ◽  
Assumpta Caixàs Pedragós ◽  
Ricardo Gómez-Huelgas ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Dietary Treatment ◽  
Executive Summary

scholarly journals Effects and Underlying Mechanisms of Bioactive Compounds on Type 2 Diabetes Mellitus and Alzheimer’s Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-25 ◽  
Author(s):  
Rongzi Li ◽  
Yuxian Zhang ◽  
Suhail Rasool ◽  
Thangiah Geetha ◽  
Jeganathan Ramesh Babu
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Type 2 Diabetes ◽  
Alzheimer's Disease ◽  
Type 2 Diabetes Mellitus ◽  
Bioactive Compounds ◽  
Molecular Mechanisms ◽  
Clinical Effects ◽  
Brain Disorder

Type 2 diabetes mellitus is a complicated metabolic disorder characterized by hyperglycemia and glucose intolerance. Alzheimer’s disease is a progressive brain disorder characterized by a chronic loss of cognitive and behavioral function. Considering the shared characteristics of both diseases, common therapeutic and preventive agents may be effective. Bioactive compounds such as polyphenols, vitamins, and carotenoids found in vegetables and fruits can have antioxidant and anti-inflammatory effects. These effects make them suitable candidates for the prevention or treatment of diabetes and Alzheimer’s disease. Increasing evidence from cell or animal models suggest that bioactive compounds may have direct effects on decreasing hyperglycemia, enhancing insulin secretion, and preventing formation of amyloid plaques. The possible underlying molecular mechanisms are described in this review. More studies are needed to establish the clinical effects of bioactive compounds.

scholarly journals Patterns of adherence to management among patients with type 2 diabetes mellitus in South-South Region of Nigeria

2015 ◽  
Vol 03 (02) ◽  
pp. 115-119 ◽  
Author(s):  
Oyewole Emmanuel ◽  
Agofure Otovwe
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Dietary Treatment ◽  
Public Healthcare ◽  
Adherence To Treatment ◽  
Patient Counseling ◽  
Cross Sectional ◽  
Adherence To Medication

Abstract Aims: The study investigated the pattern of adherence to medication and dietary treatment among type 2 diabetes mellitus patients. Settings and Design: A cross-sectional study conducted among 350 consented patients with type 2 diabetes mellitus from a secondary public healthcare facility. Materials and Methods: A semistructured questionnaire was interviewer-administered to obtain information on respondents′ sociodemographic characteristics, level of adherence to medication and dietary treatment, and suggestions on ways of improving adherence to treatment. Descriptive statistics, chi-square test, and logistic regression were used to analyze the data with level of significance set at 0.05. Results: Mean age of respondents was 57.9 ± 9.8 years, 60.9% were females and 78.0% were married. Some respondents exhibited total adherence to medication (58.9%) and dietary (67.4%) treatment, respectively. Determinants of nonadherence to medication and dietary treatment include using alternative traditional medicine (herbs) for the treatment of the disease (odds ratio (OR) = 0.42, 95% confidence interval (CI) = 0.568-1.916) and consuming foods more than recommended quantity (OR = 6.28, 95% CI = 3.919-10.083). One of the suggested ways by the respondents to improve adherence to treatment was self-discipline (46.9%). Lack of awareness on the seriousness of the disease (42.6%) was a major challenge confronting patients with type 2 diabetes mellitus. Creation of awareness on the seriousness of the disease was suggested by 39.1% of respondents. Conclusions: Use of alternative medicine (herbs) and eating more than the recommended quantity of foods remain a challenge among patients with type 2 diabetes mellitus. Comprehensive health promotion and education strategies including patient counseling on diabetes care with emphasis on adherence to medication and dietary treatment regimen should be organized regularly for diabetes patients.

Executive summary: Updates to the dietary treatment of prediabetes and type 2 diabetes mellitus

2021 ◽  
Author(s):  
V. Pascual Fuster ◽  
A. Pérez Pérez ◽  
J. Carretero Gómez ◽  
A. Caixàs Pedragós ◽  
R. Gómez-Huelgas ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Dietary Treatment ◽  
Executive Summary
Sign in / Sign up

Export Citation Format

Share Document