Protective effects of a mixed plant extracts derived from Astragalus membranaceus and Laminaria japonica on PTU‐induced hypothyroidism and liver damages

2019 ◽  
Vol 43 (7) ◽  
Author(s):  
Md. Mohibbullah ◽  
Khawaja Muhammad Imran Bashir ◽  
Sung‐Kew Kim ◽  
Yong‐Ki Hong ◽  
Andre Kim ◽  
...  
Keyword(s):  
Plant Extracts ◽  
Laminaria Japonica ◽  
Astragalus Membranaceus ◽  
Protective Effects

scholarly journals Vascular protective effects of Astragalus membranaceus and its main constituents in rats with chronic hyperhomocysteinemia

2017 ◽  
Vol 14 (3) ◽  
pp. 2401-2407 ◽  
Author(s):  
Li-Hong Qiu ◽  
Bi-Qi Zhang ◽  
Miao-Jun Lian ◽  
Xian-Ji Xie ◽  
Peng Chen
Keyword(s):  
Astragalus Membranaceus ◽  
Protective Effects

scholarly journals Astragalus membranaceus and Panax notoginseng, the Novel Renoprotective Compound, Synergistically Protect against Podocyte Injury in Streptozotocin-Induced Diabetic Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Ruonan Zhai ◽  
Guihua Jian ◽  
Teng Chen ◽  
Ling Xie ◽  
Rui Xue ◽  
...  
Keyword(s):  
Panax Notoginseng ◽  
Diabetic Rats ◽  
Astragalus Membranaceus ◽  
Protective Effects ◽  
The Novel ◽  
Podocyte Injury ◽  
Renal Histopathology ◽  
Foot Process ◽  
Immunofluorescence Labeling ◽  
Renal Expression

This study was aimed at investigating the synergistical protective effects of Astragalus membranaceus (AG) and Panax notoginseng (NG) on podocyte injury in diabetic rats. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin at 55 mg/kg. Diabetic rats were then orally administrated with losartan, AG, NG, and AG plus NG (2 : 1) for 12 weeks. Albuminuria, biochemical markers, renal histopathology, and podocyte number per glomerulus were measured. Podocyte apoptosis was determined by triple immunofluorescence labeling including TUNEL assay, WT1, and DAPI. Renal expression of nephrin, α-dystroglycan, Bax, Bcl-xl, and Nox4 was evaluated by immunohistochemistry, western blot, and RT-PCR. AG plus NG ameliorated albuminuria, renal histopathology, and podocyte foot process effacement to a greater degree than did AG or NG alone. The number of podocytes per glomerulus, as well as renal expression of nephrin, α-dystroglycan, and Bcl-xl, was decreased, while podocyte apoptosis, as well as renal expression of Bax and Nox4, was increased in diabetic rats. All of these abnormalities were partially restored by AG plus NG to a greater degree than did AG or NG alone. In conclusion, AG and NG synergistically ameliorated diabetic podocyte injury partly through upregulation of nephrin, α-dystroglycan, and Bcl-xl, as well as downregulation of Bax and Nox4. These findings might provide a novel treatment combination for DN.

scholarly journals Chemical Profiling of Astragalus membranaceus Roots (Fish.) Bunge Herbal Preparation and Evaluation of Its Bioactivity

2020 ◽  
Vol 15 (5) ◽  
pp. 1934578X2092415 ◽  
Author(s):  
Valentina Santoro ◽  
Valentina Parisi ◽  
Massimiliano D’Ambola ◽  
Chiara Sinisgalli ◽  
Magnus Monné ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Antioxidant Activities ◽  
Positive Control ◽  
Astragalus Membranaceus ◽  
Perennial Herb ◽  
Cholinesterase Inhibition ◽  
Protective Agent ◽  
Protective Effects ◽  
Simple Method ◽  
Free Hydroxy Group

Astragalus membranaceus (Fish.) Bunge is a perennial herb distributed in the northern part of China, and its roots, namely, Hang qi, are included as a natural ingredient in dietary supplement formulations commonly used to treat different disorders such as respiratory infections, diabetes, and heart failure. The availability of a simple method for the determination of the quality of Astragalus herbal preparations could be a challenging issue for commercial purposes. In this study, a liquid chromatography–mass spectrometry (LC–MS)/MS based approach was used to characterize specialized metabolite recovery of 3 commercial hydroalcoholic extracts of A. membranaceus (AMG1, AMG2, AMG3) in addition to a hydroalcoholic extract of A. membranaceus root (AST). The hypoglycemic effect, cholinesterase inhibition, and antioxidant activities were also evaluated. Thirty-one compounds, of which 19 polyphenols and 12 saponins, were identified. The extracts were also quantified by using a sensitive and selective Q-Trap system for their content in flavonoids and astragalosides, selecting astragaloside I and IV as chemical markers. From our results, AMG3 preparation (Axtragyl) was the most abundant in terms of both specialized classes of metabolites, showing a fingerprint similar to that of AST. Interestingly, tested enzyme inhibition ability of flavonoids, daidzein (11) and formononetin (19), reported a higher α-glucosidase inhibition in comparison with that of acarbose used as positive control. The in silico study clarified the interactions among the molecules and the importance of having a free hydroxy group. Moreover, Axtragyl was able to exert protective effects in Caco-2 cells treated with hydrogen peroxide, confirming its ability as a potential protective agent in intestinal injury.

Protective Effects Against H2O2-Induced Damage by Enzymatic Hydrolysates of an Edible Brown Seaweed, Sea Tangle (Laminaria japonica)

2009 ◽  
Vol 12 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Pyo-Jam Park ◽  
Eun-Kyung Kim ◽  
Seung-Jae Lee ◽  
Sun-Young Park ◽  
Dong-Soo Kang ◽  
...  
Keyword(s):  
Brown Seaweed ◽  
Laminaria Japonica ◽  
Protective Effects ◽  
Enzymatic Hydrolysates

scholarly journals Modulation of Streptomycin Killing Rate against Mature Escherichia Coli Biofilms in the Presence of Medicinal Plant Extracts

2019 ◽  
Vol 4 (5) ◽  
pp. 50-54
Author(s):  
Z. Y. Samoilova ◽  
G. V. Smirnova ◽  
O. N. Oktyabrsky
Keyword(s):  
Escherichia Coli ◽  
Medicinal Plant ◽  
Plant Extracts ◽  
Biofilm Formation ◽  
Antioxidant Properties ◽  
Laminaria Japonica ◽  
Black Tea ◽  
Killing Rate ◽  
Medicinal Plant Extracts ◽  
High Doses

Background. Medicinal plant extracts exhibiting pro- and antioxidant properties may affect antibiotic-induced killing of biofilm-producing bacteria in both synergistic and antagonistic modes. Better understanding of these alternations is required to adjust antibiotic therapy and herbal medicine in order to exclude unwanted losses of antibiotic efficiency.Aim: to study modulation modes of streptomycin killing rate against mature biofilms of Escherichia coli in the presence of different doses of commonly used medicinal plant extracts.Materials and methods. Pharmacodynamic parameter killing rate and mass biofilm formation were determined in the presence of streptomycin and medicinal plant extracts.Results. Synergism was found between 100 mg/ml streptomycin and low doses (0.83 mg of dry herb/ml) of green, black tea, Arctostaphylos uva-ursi, Betula pendula and Laminaria japonica against killing mature biofilms. Alternatively, high doses (6.64 mg of dry herb/ml) of green, black tea and Vaccinium vitis-ideae demonstrated antagonism, decreasing killing rate and enhancing biofilm formation. Presumably, high doses of the extracts were sufficient to enhance biofilm formation blocking penetration of streptomycin through enlarged biofilm matrix and diminishing the killing rate.Conclusions. Widely consumed as soft beverages or for prophylactic purposes green, black tea and V. vitis-ideae could promote strong antagonistic effects with streptomycin. These extracts can stimulate biofilm production, making benefit for commensal microbiota, but have clinical relevance due to a significant reduction in the lethal efficiency of streptomycin in biofilms of pathogenic strains. This highlights the need of careful antibiotic prescription scheme adjustment when choosing appropriate combinations of plant extracts and antibiotics to achieve a synergistic effect.

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