scholarly journals Associations between urinary 6‐sulfatoxymelatonin excretion and diabetic vascular complications or arteriosclerosis in patients with type 2 diabetes

2020 ◽  
Author(s):  
Kenichi Tanaka ◽  
Yosuke Okada ◽  
Hajime Maiko ◽  
Hiroko Mori ◽  
Yoshiya Tanaka
Keyword(s):  
Type 2 Diabetes ◽  
Vascular Complications ◽  
Diabetic Vascular Complications

Association of C-peptide with diabetic vascular complications in type 2 diabetes

2020 ◽  
Vol 46 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Y. Wang ◽  
H. Wan ◽  
Y. Chen ◽  
F. Xia ◽  
W. Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vascular Complications ◽  
C Peptide ◽  
Diabetic Vascular Complications

scholarly journals GRB10 rs1800504 Polymorphism Is Associated With the Risk of Coronary Heart Disease in Patients With Type 2 Diabetes Mellitus

2021 ◽  
Vol 8 ◽  
Author(s):  
Yang Yang ◽  
Wentao Qiu ◽  
Qian Meng ◽  
Mouze Liu ◽  
Weijie Lin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Type 2 Diabetes Mellitus ◽  
Heart Disease ◽  
Vascular Complications ◽  
Nucleotide Polymorphisms ◽  
Diabetic Vascular Complications ◽  
Increased Risk

Diabetic vascular complications are one of the main causes of death and disability. Previous studies have reported that genetic variation is associated with diabetic vascular complications. In this study, we aimed to investigate the association between GRB10 polymorphisms and susceptibility to type 2 diabetes mellitus (T2DM) vascular complications. Eight single nucleotide polymorphisms (SNPs) in the GRB10 gene were genotyped by MassARRAY system and 934 patients with type 2 diabetes mellitus (T2DM) were included for investigation. We found that GRB10 rs1800504 CC+CT genotypes were significantly associated with increased risk of coronary heart disease (CHD) compared with TT genotype (OR = 2.24; 95%CI: 1.36–3.70, p = 0.002). Consistently, levels of cholesterol (CHOL) (CC+CT vs. TT, 4.44 ± 1.25 vs. 4.10 ± 1.00 mmol/L; p = 0.009) and low density lipoprotein cholesterin (LDL-CH) (CC+CT vs. TT, 2.81 ± 1.07 vs. 2.53 ± 0.82 mmol/L; p = 0.01) in T2DM patients with TT genotype were significant lower than those of CC+CT genotypes. We further validated in MIHA cell that the total cholesterol (TC) level in GRB10-Mut was significantly reduced compared with GRB10-WT; p = 0.0005. Likewise, the reversed palmitic acid (PA) induced lipid droplet formation in GRB10-Mut was more effective than in GRB10-WT. These results suggest that rs1800504 of GRB10 variant may be associated with the blood lipids and then may also related to the risk of CHD in patients with T2DM.

scholarly journals The K469E genetic variant in the ICAM1 gene is associated with type 2 diabetes but not with its vascular complications: a meta-analysis

2019 ◽  
Vol 9 (2) ◽  
pp. e16-e16
Author(s):  
Saikrishna Lakkakula ◽  
Henu Kumar Verma ◽  
Bhaskar V.K.S. Lakkakula
Keyword(s):  
Type 2 Diabetes ◽  
Meta Analysis ◽  
Vascular Complications ◽  
Intercellular Adhesion Molecule ◽  
Web Tool ◽  
Intercellular Adhesion Molecule 1 ◽  
Multiple Organs ◽  
Diabetic Vascular Complications ◽  
Increased Risk

Introduction: Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by diminished insulin secretion and hyperglycemia leading to damage of multiple organs. The present study is aimed to test the association between type 2 diabetes vascular complications and K469E variant (rs5498) of the intercellular adhesion molecule-1 (ICAM1) gene. Methods: Online databases were searched to retrieve all publications relating to the ICAM1 rs5498 variant in human diabetic vascular complications. In the present meta-analysis, we included all eligible studies and calculated the pooled results using MetaGenyo web tool. Results: Studies concerning ICAM1 gene K469E variant association with either type 2 diabetes or diabetes related vascular complications were included in this meta-analysis. Fifteen articles were included in this analysis (n=10 for T2DM; n=5 for diabetes nephropathy; n=8 for diabetes retinopathy). ICAM1 K469E variant significantly increased the risk of T2DM in the allelic (OR = 1.10, 95% CI: 1.01-1.20, P = 0.032) and recessive models (OR = 1.27, 95% CI: 1.08-1.49, P = 0.004). However, the ICAM1 gene K469E variant is not associated with diabetic nephropathy or diabetic retinopathy. No noticeable evidence of publication bias was detected. Conclusion: In summary, our study indicated that ICAM1 K469E variant was significantly associated with the increased risk of diabetes but not with the diabetic vascular complications.

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