Telmisartan protects against diabetic vascular complications in a mouse model of obesity and type 2 diabetes, partially through peroxisome proliferator activated receptor-γ-dependent activity

2011 ◽  
Vol 410 (3) ◽  
pp. 508-513 ◽  
Author(s):  
Kensuke Toyama ◽  
Taishi Nakamura ◽  
Keiichiro Kataoka ◽  
Osamu Yasuda ◽  
Masaya Fukuda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Model ◽  
Vascular Complications ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Diabetic Vascular Complications ◽  
Dependent Activity

scholarly journals Characterization of a Novel Polymorphism in PPARG Regulatory Region Associated with Type 2 Diabetes and Diabetic Retinopathy in Italy

2009 ◽  
Vol 2009 ◽  
pp. 1-7 ◽  
Author(s):  
Valerio Costa ◽  
Amelia Casamassimi ◽  
Katherine Esposito ◽  
Angela Villani ◽  
Mariaelena Capone ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Direct Sequencing ◽  
Regulatory Region ◽  
Vascular Complications ◽  
Proliferative Retinopathy ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Significant Difference

Peroxisome proliferator-activated receptor gamma polymorphisms have been widely associated with type 2 diabetes, although their role in the pathogenesis of vascular complications is not yet demonstrated. In this study, a cohort of 211 type 2 diabetes, 205 obese, and 254 control individuals was genotyped for Pro12Ala, C1431T, C-2821T polymorphisms, and for a newly identified polymorphism (A-2819G). The above-mentioned polymorphisms were analyzed by gene-specific PCR and direct sequencing of all samples. A significant difference was found for -2819G frequency when patients with type 2 diabetes—particularly diabetic women with the proliferative retinopathy—were compared with healthy control individuals. In conclusion, we identified a novel polymorphism, A-2819G, inPPARGgene, and we found it to be associated with type 2 diabetes and proliferative retinopathy in diabetic females. In the analyzed population, this variant represents a genetic risk factor for developing the diabetic retinopathy, whereas Pro12Ala and C1431T do not.

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