scholarly journals Morphometric features of corneal epithelial basal cells, and their relationship with corneal nerve pathology and clinical factors in patients with type 2 diabetes

2013 ◽  
Vol 4 (5) ◽  
pp. 492-501 ◽  
Author(s):  
Fukashi Ishibashi ◽  
Asami Kawasaki ◽  
Emi Yamanaka ◽  
Aiko Kosaka ◽  
Harumi Uetake
Keyword(s):  
Type 2 Diabetes ◽  
Basal Cells ◽  
Clinical Factors ◽  
Corneal Epithelial ◽  
Morphometric Features ◽  
Corneal Nerve

1460-P: Type 2 Diabetes Polygenic Score in Addition to Clinical Factors for Prediction of Diabetes Incidence in an Indigenous American Population

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1460-P
Author(s):  
LAUREN E. WEDEKIND ◽  
SAYUKO KOBES ◽  
WEN-CHI HSUEH ◽  
LESLIE BAIER ◽  
WILLIAM C. KNOWLER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Incidence ◽  
American Population ◽  
Clinical Factors ◽  
Polygenic Score ◽  
Prediction Of Diabetes ◽  
P Type

scholarly journals Insulin resistance limits corneal nerve regeneration in patients with Type 2 diabetes undergoing intensive glycemic control

2021 ◽  
Author(s):  
Georgios Ponirakis ◽  
Muhammad A. Abdul‐Ghani ◽  
Amin Jayyousi ◽  
Mahmoud A. Zirie ◽  
Salma Al‐Mohannadi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Nerve Regeneration ◽  
Intensive Glycemic Control ◽  
Corneal Nerve

scholarly journals Kidney Biomarkers and Decline in eGFR in Patients with Type 2 Diabetes

2018 ◽  
Vol 13 (3) ◽  
pp. 398-405 ◽  
Author(s):  
Katherine G. Garlo ◽  
William B. White ◽  
George L. Bakris ◽  
Faiez Zannad ◽  
Craig A. Wilson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Confidence Interval ◽  
Cystatin C ◽  
Hazard Ratio ◽  
Clinical Factors ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
C Statistic ◽  
Neutrophil Gelatinase ◽  
Egfr Decline

Background and objectivesBiomarkers may improve identification of individuals at risk of eGFR decline who may benefit from intervention or dialysis planning. However, available biomarkers remain incompletely validated for risk stratification and prediction modeling.Design, setting, participants, & measurementsWe examined serum cystatin C, urinary kidney injury molecule–1 (uKIM-1), and urinary neutrophil gelatinase-associated lipocalin (UNGAL) in 5367 individuals with type 2 diabetes mellitus and recent acute coronary syndromes enrolled in the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) trial. Baseline concentrations and 6-month changes in biomarkers were also evaluated. Cox proportional regression was used to assess associations with a 50% decrease in eGFR, stage 5 CKD (eGFR<15 ml/min per 1.73 m2), or dialysis.ResultseGFR decline occurred in 98 patients (1.8%) over a median of 1.5 years. All biomarkers individually were associated with higher risk of eGFR decline (P<0.001). However, when adjusting for baseline eGFR, proteinuria, and clinical factors, only baseline cystatin C (adjusted hazard ratio per 1 SD change, 1.66; 95% confidence interval, 1.41 to 1.96; P<0.001) and 6-month change in urinary neutrophil gelatinase-associated lipocalin (adjusted hazard ratio per 1 SD change, 1.07; 95% confidence interval, 1.02 to 1.12; P=0.004) independently associated with CKD progression. A base model for predicting kidney function decline with nine standard risk factors had strong discriminative ability (C-statistic 0.93). The addition of baseline cystatin C improved discrimination (C-statistic 0.94), but it failed to reclassify risk categories of individuals with and without eGFR decline.ConclusionsThe addition of cystatin C or biomarkers of tubular injury did not meaningfully improve the prediction of eGFR decline beyond common clinical factors and routine laboratory data in a large cohort of patients with type 2 diabetes and recent acute coronary syndrome.PodcastThis article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_01_16_CJASNPodcast_18_3_G.mp3

scholarly journals Reduced corneal nerve fibre length in prediabetes and type 2 diabetes: The Maastricht Study

2020 ◽  
Vol 98 (5) ◽  
pp. 485-491 ◽  
Author(s):  
Eline E.B. De Clerck ◽  
Jan S.A.G. Schouten ◽  
Tos T.J.M. Berendschot ◽  
Renée S. Koolschijn ◽  
Rudy M.M.A. Nuijts ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Nerve Fibre ◽  
Fibre Length ◽  
Corneal Nerve

scholarly journals CLINICAL FACTORS ASSOCIATED WITH SUDDEN CARDIAC DEATH IN TYPE 2 DIABETES: INSIGHTS FROM THE SAVOR-TIMI 53 TRIAL

2016 ◽  
Vol 67 (13) ◽  
pp. 2083 ◽  
Author(s):  
Ilaria Cavallari ◽  
Ravi Patel ◽  
Deepak Bhatt ◽  
Philippe Steg ◽  
Lawrence Leiter ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Clinical Factors ◽  
Factors Associated

scholarly journals Glycemic Control Rate in Type 2 Diabetes Mellitus Patients at a Public Referral Hospital in Rio de Janeiro, Brazil: Demographic and Clinical Factors

2017 ◽  
Vol 7 (2) ◽  
pp. 61-67 ◽  
Author(s):  
Natasha Reis Lozovey ◽  
Elisa Baranski Lamback ◽  
Raissa Barros Mota ◽  
Michelle Botelho Caarls ◽  
Leonardo Vieira Neto
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Rio De Janeiro ◽  
Referral Hospital ◽  
Clinical Factors
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