scholarly journals Progesterone receptor membrane component 1 is involved in oral cancer cell metastasis

2020 ◽  
Vol 24 (17) ◽  
pp. 9737-9751
Author(s):  
Hsun‐Yu Huang ◽  
Hsiu‐Chuan Chou ◽  
Ching‐Hsuan Law ◽  
Wan‐Ting Chang ◽  
Tzu‐Ning Wen ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Progesterone Receptor ◽  
Cancer Cell ◽  
Membrane Component ◽  
Receptor Membrane ◽  
Oral Cancer Cell ◽  
Cell Metastasis

scholarly journals Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Chih-Yu Peng ◽  
Hui-Wen Yang ◽  
Yin-Hung Chu ◽  
Yu-Chao Chang ◽  
Ming-Ju Hsieh ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Matrix Metalloproteinase ◽  
Caffeic Acid ◽  
Cancer Cell ◽  
Cancer Metastasis ◽  
Caffeic Acid Phenethyl Ester ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Oral Cancer Cell ◽  
Cell Metastasis

Caffeic acid phenethyl ester (CAPE), an active component extracted from honeybee hives, exhibits anti-inflammatory and anticancer activities. However, the molecular mechanism by which CAPE affects oral cancer cell metastasis has yet to be elucidated. In this study, we investigated the potential mechanisms underlying the effects of CAPE on the invasive ability of SCC-9 oral cancer cells. Results showed that CAPE attenuated SCC-9 cell migration and invasion at noncytotoxic concentrations (0 μM to 40 μM). Western blot and gelatin zymography analysis findings further indicated that CAPE downregulated matrix metalloproteinase-2 (MMP-2) protein expression and inhibited its enzymatic activity. CAPE exerted its inhibitory effects on MMP-2 expression and activity by upregulating tissue inhibitor of metalloproteinase-2 (TIMP-2) and potently decreased migration by reducing focal adhesion kinase (FAK) phosphorylation and the activation of its downstream signaling molecules p38/MAPK and JNK. These data indicate that CAPE could potentially be used as a chemoagent to prevent oral cancer metastasis.

scholarly journals Retraction: MMP-13 is involved in oral cancer cell metastasis

Oncotarget ◽  
2016 ◽  
Vol 7 (30) ◽  
pp. 48851-48851 ◽  
Author(s):  
Shun-Hong Huang ◽  
Ching-Hsuan Law ◽  
Ping-Hsueh Kuo ◽  
Ren-Yu Hu ◽  
Ching-Chieh Yang ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cell ◽  
Oral Cancer Cell ◽  
Cell Metastasis

scholarly journals MMP-13 is involved in oral cancer cell metastasis

Oncotarget ◽  
2016 ◽  
Vol 7 (13) ◽  
pp. 17144-17161 ◽  
Author(s):  
Shun-Hong Huang ◽  
Ching-Hsuan Law ◽  
Ping-Hsueh Kuo ◽  
Ren-Yu Hu ◽  
Ching-Chieh Yang ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cell ◽  
Oral Cancer Cell ◽  
Cell Metastasis

scholarly journals Regulation of Ovarian Cancer Cell Viability and Sensitivity to Cisplatin by Progesterone Receptor Membrane Component-1

2008 ◽  
Vol 93 (5) ◽  
pp. 1592-1599 ◽  
Author(s):  
John J. Peluso ◽  
Xiufang Liu ◽  
M. Melinda Saunders ◽  
Kevin P. Claffey ◽  
Kathryn Phoenix
Keyword(s):  
Ovarian Cancer ◽  
Progesterone Receptor ◽  
Cell Viability ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Membrane Component ◽  
Receptor Membrane

scholarly journals Pinostilbene Hydrate Suppresses Human Oral Cancer Cell Metastasis by Downregulation of Matrix Metalloproteinase-2 Through the Mitogen-Activated Protein Kinase Signaling Pathway

2018 ◽  
Vol 50 (3) ◽  
pp. 911-923 ◽  
Author(s):  
Ming-Ju Hsieh ◽  
Mei-Chung Chin ◽  
Chia-Chieh Lin ◽  
Yi-Ting His ◽  
Yu-Sheng Lo ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Mitogen Activated Protein Kinase ◽  
Matrix Metalloproteinase 2 ◽  
Migration And Invasion ◽  
Protein Activity ◽  
Oral Cancer Cell ◽  
Cell Metastasis ◽  
Mitogen Activated Protein

Background/Aims: Cancer is the most common cause of death worldwide with approximately one third of people being diagnosed with cancer in their lifetime. Pinostilbene hydrate (PSH) A methylated derivative of resveratrol Has been reported to possess antioxidative Cardioprotective and anticancer properties. However the antimetastatic effect of pinostilbene in oral squamous cell carcinoma (OSCC) remains unknown. Methods: In this study We investigated the effect of PSH on antimetastatic activity and the relevant signaling pathways underlying mechanisms of SCC-9 SAS and HSC-3 oral cancer cell lines by MTT assay Wound healing Transwell assay Zymography and western blot analysis. Results: Our findings indicated that PSH inhibits migration and invasion ability by reducing the protein activity and expression of matrix metalloproteinases-2 (MMP-2) in all three cell lines. Moreover • The phosphorylation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinases (p38) had significant inhibitory effects in the presence of PSH in the SCC9 and SAS cell lines. A combination of ERK1/2 and p38 inhibitors with PSH also reduced the migration and activity of MMP-2 in the SCC9 and SAS cell lines. Conclusion: This study demonstrated that PSH suppresses MMP-2 enzymatic activity by downregulating the p38/ERK1/2 pathway and that it might be a promising agent for preventing OSCC cell metastasis.

scholarly journals Triptolide suppresses oral cancer cell PD-L1 expression in the interferon-γ-modulated microenvironment in vitro, in vivo, and in clinical patients

2021 ◽  
Vol 133 ◽  
pp. 111057
Author(s):  
Chin-Shan Kuo ◽  
Cheng-Yu Yang ◽  
Chih-Kung Lin ◽  
Gu-Jiun Lin ◽  
Huey-Kang Sytwu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cell ◽  
Interferon Γ ◽  
Oral Cancer Cell

scholarly journals Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3265
Author(s):  
Yasuaki Kabe ◽  
Ikko Koike ◽  
Tatsuya Yamamoto ◽  
Miwa Hirai ◽  
Ayaka Kanai ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Cancer Progression ◽  
Egf Receptor ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Human Colon ◽  
Titration Calorimetry ◽  
Membrane Component ◽  
Human Colon Cancer ◽  
Receptor Membrane

Progesterone receptor membrane component 1 (PGRMC1) is highly expressed in various cancer cells and contributes to tumor progression. We have previously shown that PGRMC1 forms a unique heme-stacking functional dimer to enhance EGF receptor (EGFR) activity required for cancer proliferation and chemoresistance, and the dimer dissociates by carbon monoxide to attenuate its biological actions. Here, we determined that glycyrrhizin (GL), which is conventionally used to ameliorate inflammation, specifically binds to heme-dimerized PGRMC1. Binding analyses using isothermal titration calorimetry revealed that some GL derivatives, including its glucoside-derivative (GlucoGL), bind to PGRMC1 potently, whereas its aglycone, glycyrrhetinic acid (GA), does not bind. GL and GlucoGL inhibit the interaction between PGRMC1 and EGFR, thereby suppressing EGFR-mediated signaling required for cancer progression. GL and GlucoGL significantly enhanced EGFR inhibitor erlotinib- or cisplatin (CDDP)-induced cell death in human colon cancer HCT116 cells. In addition, GL derivatives suppressed the intracellular uptake of low-density lipoprotein (LDL) by inhibiting the interaction between PGRMC1 and the LDL receptor (LDLR). Effects on other pathways cannot be excluded. Treatment with GlucoGL and CDDP significantly suppressed tumor growth following xenograft transplantation in mice. Collectively, this study indicates that GL derivatives are novel inhibitors of PGRMC1 that suppress cancer progression, and our findings provide new insights for cancer treatment.

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