IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation

2015 ◽  
Vol 26 (7) ◽  
pp. 715-723 ◽  
Author(s):  
ANNETTE BUUR STEFFENSEN ◽  
LENA REFSGAARD ◽  
MARTIN NYBO ANDERSEN ◽  
CECILIA VALLET ◽  
AMER MUJEZINOVIC ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Loss Of Function ◽  
Lone Atrial Fibrillation ◽  
Gain And Loss

scholarly journals Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation

JAMA ◽  
2018 ◽  
Vol 320 (22) ◽  
pp. 2354 ◽  
Author(s):  
Seung Hoan Choi ◽  
Lu-Chen Weng ◽  
Carolina Roselli ◽  
Honghuang Lin ◽  
Christopher M. Haggerty ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Loss Of Function ◽  
Onset Atrial Fibrillation

Functional consequences of genetic variation in sodium channel modifiers in early onset lone atrial fibrillation

2018 ◽  
Vol 15 (2) ◽  
pp. 93-102 ◽  
Author(s):  
Federico Denti ◽  
Christian Paludan-Müller ◽  
Søren-Peter Olesen ◽  
Stig Haunsø ◽  
Jesper Hastrup Svendsen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Genetic Variation ◽  
Sodium Channel ◽  
Early Onset ◽  
Lone Atrial Fibrillation ◽  
Functional Consequences

scholarly journals Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early‐onset lone atrial fibrillation

2019 ◽  
Vol 24 (6) ◽  
Author(s):  
Mariam B. Seifert ◽  
Morten S. Olesen ◽  
Ingrid E. Christophersen ◽  
Jonas B. Nielsen ◽  
Jonas Carlson ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Genetic Variants ◽  
Early Onset ◽  
Electrical Activation ◽  
Lone Atrial Fibrillation

scholarly journals RARE LOSS-OF-FUNCTION VARIANT ANALYSIS IN LONE ATRIAL FIBRILLATION

2019 ◽  
Vol 35 (10) ◽  
pp. S156-S157
Author(s):  
J. Lazarte ◽  
J. Wang ◽  
J. Robinson ◽  
J. Dron ◽  
A. McIntyre ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Loss Of Function ◽  
Lone Atrial Fibrillation ◽  
Variant Analysis

Common Polymorphisms in KNCJ5 Are Associated with Early-Onset Lone Atrial Fibrillation in Caucasians

Cardiology ◽  
2011 ◽  
Vol 118 (2) ◽  
pp. 116-120 ◽  
Author(s):  
Javad Jabbari ◽  
Morten S. Olesen ◽  
Anders G. Holst ◽  
Jonas B. Nielsen ◽  
Stig Haunso ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Lone Atrial Fibrillation

Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation

Heart Rhythm ◽  
2014 ◽  
Vol 11 (2) ◽  
pp. 246-251 ◽  
Author(s):  
Morten S. Olesen ◽  
Laura Andreasen ◽  
Javad Jabbari ◽  
Lena Refsgaard ◽  
Stig Haunsø ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Rare Variants ◽  
Lone Atrial Fibrillation ◽  
High Prevalence

scholarly journals A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation

2013 ◽  
Vol 98 (3) ◽  
pp. 488-495 ◽  
Author(s):  
Morten Salling Olesen ◽  
Lena Refsgaard ◽  
Anders Gaarsdal Holst ◽  
Anders Peter Larsen ◽  
Søren Grubb ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Gain Of Function ◽  
Lone Atrial Fibrillation

Abstract 16403: Prevalence and Sex Differences in Early-onset Atrial Fibrillation - A Nation-wide Primary Care Study in Norway

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Silje M Kalstø ◽  
Ståle Nygård ◽  
Arnljot Tveit ◽  
Inger Ariansen ◽  
Ingrid E Christophersen
Keyword(s):  
Atrial Fibrillation ◽  
Primary Care ◽  
Sex Differences ◽  
Early Onset ◽  
Age Groups ◽  
Age Group ◽  
Lone Atrial Fibrillation ◽  
Primary Care Population ◽  
Primary Care Sector

Background: Several studies have reported a male:female ratio of 4:1 in lone atrial fibrillation (AF) populations. However, there have been few reports on the young population with AF, and no reports from a primary care setting. Here, we describe prevalence and sex-differences in early-onset AF in a nation-wide register-based study in the primary care sector in Norway. Methods: In Norway, with a population of 5.4 million, healthcare is publicly financed and all general practitioner (GP) claims have been recorded in the Norwegian Control and Payment of Health Reimbursement (KUHR) registry, since 2006. We identified all individuals aged ≥18 and <50 years registered with ≥1 AF diagnosis code (International Classification of Primary Care (ICPC) K78), from 2006-2019 in the KUHR registry. Based on population estimates from Statistics Norway, we calculated the prevalence of early-onset AF in 2019, as a total, by sex, and by age groups: 18-29, 30-39, 40-49. Results: We identified 5563 individuals (28.5% women, age 18-49 years) aged 18-49 in 2019 with AF diagnosed <age 50 years. In 2019, the prevalence of early-onset AF registered in all individuals up to age 50 was 0.24% (women: 0.14% (1585/1114821), men 0.34% (3978/1176555), p=1.4x10 -205 ) with a ratio of 2.5 men:women. In individuals aged 18-29 the prevalence was 0.05% (women 0.04% (164/410367), men 0.07% (292/435001), p=79x10 -8 ). For the age group 30-39 years the prevalence was 0.19% (women 0.12% (408/349639), men 0.27% (985/367730), p=3.9x10 -49 ). For the age group 40-49 years the prevalence was 0.51% (women 0.29% (1013/354815), men 0.72% (2701/373824), p=1.39x10 -155 ). Conclusion: We show that the prevalence of early-onset AF in a nation-wide primary care population is 0.24% and that the sex-difference in prevalence is smaller than previously reported in early-onset and lone AF studies. Our findings underline the need of increased awareness of AF as a disease in the young, and particularly to women in the youngest age-groups.

scholarly journals A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Kristoffer M A Henningsen ◽  
Morten S Olesen ◽  
Golnaz Sajadieh ◽  
Stig Haunsoe ◽  
Jesper H Svendsen
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Lone Atrial Fibrillation

Association of rs2200733 at 4q25 with early onset of lone atrial fibrillation in young patients

2011 ◽  
Vol 45 (6) ◽  
pp. 324-326 ◽  
Author(s):  
Kristoffer M. A. Henningsen ◽  
Morten S. Olesen ◽  
Stig Haunsoe ◽  
Jesper H. Svendsen
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Young Patients ◽  
Lone Atrial Fibrillation
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