scholarly journals Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early‐onset lone atrial fibrillation

2019 ◽  
Vol 24 (6) ◽  
Author(s):  
Mariam B. Seifert ◽  
Morten S. Olesen ◽  
Ingrid E. Christophersen ◽  
Jonas B. Nielsen ◽  
Jonas Carlson ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Genetic Variants ◽  
Early Onset ◽  
Electrical Activation ◽  
Lone Atrial Fibrillation

scholarly journals High frequency of long qt syndrome-associated genetic variants in patients with early-onset lone atrial fibrillation

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P2303-P2303
Author(s):  
J. B. Nielsen ◽  
L. Refsgaard ◽  
J. Jabbari ◽  
A. G. Holst ◽  
S. Haunso ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Long Qt Syndrome ◽  
Genetic Variants ◽  
High Frequency ◽  
Early Onset ◽  
Long Qt ◽  
Lone Atrial Fibrillation ◽  
Qt Syndrome

Functional consequences of genetic variation in sodium channel modifiers in early onset lone atrial fibrillation

2018 ◽  
Vol 15 (2) ◽  
pp. 93-102 ◽  
Author(s):  
Federico Denti ◽  
Christian Paludan-Müller ◽  
Søren-Peter Olesen ◽  
Stig Haunsø ◽  
Jesper Hastrup Svendsen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Genetic Variation ◽  
Sodium Channel ◽  
Early Onset ◽  
Lone Atrial Fibrillation ◽  
Functional Consequences

P1392Next generation sequencing in lone atrial fibrillation patients

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
I Rudaka ◽  
D Rots ◽  
O Kalejs ◽  
L Gailite
Keyword(s):  
Atrial Fibrillation ◽  
Sudden Cardiac Death ◽  
Genetic Variants ◽  
Cardiac Death ◽  
Structural Heart Disease ◽  
Missense Variant ◽  
Lone Atrial Fibrillation ◽  
Excessive Alcohol Consumption ◽  
Pathogenic Variants ◽  
Rare Genetic Variants

Abstract Background. Minor part of atrial fibrillation (AF) patients develops the disease without any well-known risk factors, which is a particular form of the disease, known as a lone AF. Rare genetic variants were described as causative for lone AF. The aim of this study was to investigate occurrence of rare genetic variants in lone AF patients. Material and Methods. We performed Mendeliome sequencing for 21 lone AF patients. Lone AF was defined as AF in individuals younger than 65 years in the absence of cardiovascular or structural heart disease, endocrinologic or pulmonary disease, chronic kidney disease, obesity and excessive alcohol consumption. Data analysis was performed by current laboratory pipeline. We analyzed 453 cardiomyopathy, arrhythmias and sudden cardiac death related genes. Results. In eight out of 21 (38%) lone AF patients rare likely pathogenic variants were found (Table 1.). Seven rare truncating TTN variants and one LMNA missense variant were observed. Four unrelated patients were positive for the same TTN variant c.13696 C > T; p.(Gln4566Ter). The same variant was previously found in ARVC patient in our laboratory. Segregation analysis and phenotyping of relatives is ongoing. Conclusions. Rare genetic variants are common causes of the lone atrial fibrillation. TTN gene variant c.13696C > T; p.(Gln4566Ter) is a potential founder variant in the Baltic population. Table 1. Genetic variants in lone AF Gender Age of AF onset Genetic variant Family history Male 53 LMNA: p.(Ser326Thr) AF in mother Male 11 TTN: p.(Trp31854Ter) AF in father Male 30 TTN: p.(GLn4566Ter) AF in uncle Female 45 TTN: p.(GLn4566Ter) Negative Male 37 TTN: p.(GLn4566Ter) AF in father Male 25 TTN: p.(GLn4566Ter) AF in father, maternal and paternal grandmother Female 60 TTN: p.(Arg27414Ter) Sudden cardiac death at the age of 50 in grand father Female 52 TTN: p.(Arg1012Ter) AF in mother

scholarly journals Candidate gene approach to identifying rare genetic variants associated with lone atrial fibrillation

Heart Rhythm ◽  
2014 ◽  
Vol 11 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Peter Weeke ◽  
Babar Parvez ◽  
Marcia Blair ◽  
Laura Short ◽  
Christie Ingram ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Candidate Gene ◽  
Genetic Variants ◽  
Candidate Gene Approach ◽  
Lone Atrial Fibrillation ◽  
Rare Genetic Variants

Common Polymorphisms in KNCJ5 Are Associated with Early-Onset Lone Atrial Fibrillation in Caucasians

Cardiology ◽  
2011 ◽  
Vol 118 (2) ◽  
pp. 116-120 ◽  
Author(s):  
Javad Jabbari ◽  
Morten S. Olesen ◽  
Anders G. Holst ◽  
Jonas B. Nielsen ◽  
Stig Haunso ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Lone Atrial Fibrillation

Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation

Heart Rhythm ◽  
2014 ◽  
Vol 11 (2) ◽  
pp. 246-251 ◽  
Author(s):  
Morten S. Olesen ◽  
Laura Andreasen ◽  
Javad Jabbari ◽  
Lena Refsgaard ◽  
Stig Haunsø ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Rare Variants ◽  
Lone Atrial Fibrillation ◽  
High Prevalence

scholarly journals GENETIC VARIANTS IN SOX5 AND CAV1 ARE ASSOCIATED WITH ABNORMAL ATRIAL ACTIVATION IN PATIENTS WITH LONE ATRIAL FIBRILLATION

2014 ◽  
Vol 63 (12) ◽  
pp. A458
Author(s):  
Mariam Bashir Seifert ◽  
Morten S. Olesen ◽  
Ingrid E. Christophersen ◽  
Jonas B. Nielsen ◽  
Jonas Carlson ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Genetic Variants ◽  
Lone Atrial Fibrillation ◽  
Atrial Activation

scholarly journals A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation

2013 ◽  
Vol 98 (3) ◽  
pp. 488-495 ◽  
Author(s):  
Morten Salling Olesen ◽  
Lena Refsgaard ◽  
Anders Gaarsdal Holst ◽  
Anders Peter Larsen ◽  
Søren Grubb ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Gain Of Function ◽  
Lone Atrial Fibrillation

Abstract 16403: Prevalence and Sex Differences in Early-onset Atrial Fibrillation - A Nation-wide Primary Care Study in Norway

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Silje M Kalstø ◽  
Ståle Nygård ◽  
Arnljot Tveit ◽  
Inger Ariansen ◽  
Ingrid E Christophersen
Keyword(s):  
Atrial Fibrillation ◽  
Primary Care ◽  
Sex Differences ◽  
Early Onset ◽  
Age Groups ◽  
Age Group ◽  
Lone Atrial Fibrillation ◽  
Primary Care Population ◽  
Primary Care Sector

Background: Several studies have reported a male:female ratio of 4:1 in lone atrial fibrillation (AF) populations. However, there have been few reports on the young population with AF, and no reports from a primary care setting. Here, we describe prevalence and sex-differences in early-onset AF in a nation-wide register-based study in the primary care sector in Norway. Methods: In Norway, with a population of 5.4 million, healthcare is publicly financed and all general practitioner (GP) claims have been recorded in the Norwegian Control and Payment of Health Reimbursement (KUHR) registry, since 2006. We identified all individuals aged ≥18 and <50 years registered with ≥1 AF diagnosis code (International Classification of Primary Care (ICPC) K78), from 2006-2019 in the KUHR registry. Based on population estimates from Statistics Norway, we calculated the prevalence of early-onset AF in 2019, as a total, by sex, and by age groups: 18-29, 30-39, 40-49. Results: We identified 5563 individuals (28.5% women, age 18-49 years) aged 18-49 in 2019 with AF diagnosed <age 50 years. In 2019, the prevalence of early-onset AF registered in all individuals up to age 50 was 0.24% (women: 0.14% (1585/1114821), men 0.34% (3978/1176555), p=1.4x10 -205 ) with a ratio of 2.5 men:women. In individuals aged 18-29 the prevalence was 0.05% (women 0.04% (164/410367), men 0.07% (292/435001), p=79x10 -8 ). For the age group 30-39 years the prevalence was 0.19% (women 0.12% (408/349639), men 0.27% (985/367730), p=3.9x10 -49 ). For the age group 40-49 years the prevalence was 0.51% (women 0.29% (1013/354815), men 0.72% (2701/373824), p=1.39x10 -155 ). Conclusion: We show that the prevalence of early-onset AF in a nation-wide primary care population is 0.24% and that the sex-difference in prevalence is smaller than previously reported in early-onset and lone AF studies. Our findings underline the need of increased awareness of AF as a disease in the young, and particularly to women in the youngest age-groups.

scholarly journals A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Kristoffer M A Henningsen ◽  
Morten S Olesen ◽  
Golnaz Sajadieh ◽  
Stig Haunsoe ◽  
Jesper H Svendsen
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Lone Atrial Fibrillation
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