scholarly journals RARE LOSS-OF-FUNCTION VARIANT ANALYSIS IN LONE ATRIAL FIBRILLATION

2019 ◽  
Vol 35 (10) ◽  
pp. S156-S157
Author(s):  
J. Lazarte ◽  
J. Wang ◽  
J. Robinson ◽  
J. Dron ◽  
A. McIntyre ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Loss Of Function ◽  
Lone Atrial Fibrillation ◽  
Variant Analysis

IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation

2015 ◽  
Vol 26 (7) ◽  
pp. 715-723 ◽  
Author(s):  
ANNETTE BUUR STEFFENSEN ◽  
LENA REFSGAARD ◽  
MARTIN NYBO ANDERSEN ◽  
CECILIA VALLET ◽  
AMER MUJEZINOVIC ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Early Onset ◽  
Loss Of Function ◽  
Lone Atrial Fibrillation ◽  
Gain And Loss

scholarly journals A novel GATA5 loss-of-function mutation underlies lone atrial fibrillation

2012 ◽  
Vol 31 (1) ◽  
pp. 43-50 ◽  
Author(s):  
XIN-HUA WANG ◽  
CONG-XIN HUANG ◽  
QIAN WANG ◽  
RUO-GU LI ◽  
YING-JIA XU ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Loss Of Function ◽  
Lone Atrial Fibrillation

scholarly journals A novel PITX2c loss-of-function mutation underlies lone atrial fibrillation

2013 ◽  
Vol 32 (4) ◽  
pp. 827-834 ◽  
Author(s):  
YI-MENG ZHOU ◽  
PENG-XIANG ZHENG ◽  
YI-QING YANG ◽  
ZHI-MING GE ◽  
WEI-QIANG KANG
Keyword(s):  
Atrial Fibrillation ◽  
Loss Of Function ◽  
Lone Atrial Fibrillation

Abstract 199: Whole-Transcript Genomics Reveals Atrial KCNE1 Downregulation in a Model of Postoperative Atrial Fibrillation Susceptibility

2012 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
Ritu Kant ◽  
Zhaoyang Hu ◽  
Vikram Kanda ◽  
David J Christini ◽  
Paul Heerdt ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Influencing Factor ◽  
Major Surgery ◽  
Loss Of Function ◽  
Lone Atrial Fibrillation ◽  
Lung Lobectomy ◽  
Potential Marker ◽  
Rapid Pacing ◽  
Molecular Bases

Lone atrial fibrillation (AF) is associated with various ion channel gene sequence variants, notably the common S38G loss-of-function polymorphism in the KCNE1 K + channel ancillary subunit gene. New-onset postoperative AF (PAF) generally occurs 48-72 hours after major surgery, particularly following procedures within the chest, but its molecular bases remain poorly understood. Here, to begin to address this gap in knowledge, we analyzed molecular changes in the left atrium (LA) three days following left upper lung lobectomy in Sinclair swine in relation to simultaneous changes in hemodynamics, LA effective refractory period (ERP), and the capacity to sustain electrically-induced AF. Relative to control pigs (no previous surgery), lobectomy increased mean pulmonary artery pressure (16 ± 3 vs 22 ± 5 mm Hg; P = 0.045) and pulmonary vascular resistance (273 ± 93 vs 481 ± 142 dyn¶s/cm 5 ; P = 0.025), whereas other hemodynamic parameters were unchanged. Left atrial ERP measured from a 300 ms cycle length trended toward reduction in lobectomy animals (187 ± 37 vs 170 ± 44 ms, P >0.05). None of the lobectomy pigs developed spontaneous postoperative AF as assessed by telemetric ECG. However, all lobectomy pigs, but none of the controls, were able to sustain AF induced by a 10 s burst of rapid pacing for ≥30 s ( P =0.0079), independent of atrial ERP; AF was sustained ≥60 s in 3/5 postoperative pigs versus 0/5 controls and correlated with a shorter ERP overall ( P =0.023). Whole-transcript genomics of left atrial tissue using 25 probes per transcript revealed 13 genes with expression changes ≥2-fold in postoperative pigs. Strikingly, of these, atrial KCNE1 showed the statistically strongest link to surgery, and was the most downregulated gene in the postoperative group compared to controls (2.2-fold reduced, P =0.0027), recapitulated at the protein level with western blotting ( P =0.039). The data suggest KCNE1 remodeling as a potential marker or influencing factor in the early progression of, or susceptibility to, PAF [[Unable to Display Character: –]] uncovering a possible common predisposing genetic factor in PAF and lone AF.

Genetic Aspects of Lone Atrial Fibrillation: What Do We Know?

2014 ◽  
Vol 21 (5) ◽  
pp. 667-678 ◽  
Author(s):  
Laura Andreasen ◽  
Jonas Nielsen ◽  
Morten Olesen
Keyword(s):  
Atrial Fibrillation ◽  
Lone Atrial Fibrillation

Lone Atrial Fibrillation- A Diagnosis of Exclusion

2014 ◽  
Vol 21 (5) ◽  
pp. 544-550 ◽  
Author(s):  
Antonio Tello-Montoliu ◽  
Diana Hernández-Romero ◽  
Marianela Sanchez-Martínez ◽  
Mariano Valdes ◽  
Francisco Marín
Keyword(s):  
Atrial Fibrillation ◽  
Lone Atrial Fibrillation

Lone Atrial Fibrillation: Electrophysiology, Risk Factors, Catheter Ablation and Other Non-pharmacologic Treatments

2014 ◽  
Vol 21 (5) ◽  
pp. 580-590 ◽  
Author(s):  
Arun Kanmanthareddy ◽  
Martin Emert ◽  
Rhea Pimentel ◽  
Yeruva Reddy ◽  
Sudharani Bommana ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Lone Atrial Fibrillation ◽  
Pharmacologic Treatments
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