Characterization of a novel, biofilm dispersing, lytic bacteriophage against drug‐resistant Enterobacter Cloacae

2021 ◽  
Author(s):  
Aparna Nair ◽  
Renuka Vyawahare ◽  
Krishna Khairnar
Keyword(s):  
Enterobacter Cloacae ◽  
Lytic Bacteriophage ◽  
Drug Resistant

Characterization of Two Clinical, Multiple-Drug-Resistant Isolates of Enterobacter cloacae

Chemotherapy ◽  
1984 ◽  
Vol 30 (5) ◽  
pp. 308-321 ◽  
Author(s):  
Walter H. Traub ◽  
Rolf Hüberle ◽  
Dierk Bauer
Keyword(s):  
Enterobacter Cloacae ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant

scholarly journals Characterization of a Novel Lytic Bacteriophage EC14 that Infects Enterobacter cloacae Clinical Isolates

2018 ◽  
Vol 22 (2) ◽  
pp. 169-178
Author(s):  
Hongyan Shi ◽  
◽  
Jinghua Li ◽  
Yuchong Hao ◽  
Yanbo Sun ◽  
...  
Keyword(s):  
Enterobacter Cloacae ◽  
Clinical Isolates ◽  
Lytic Bacteriophage

scholarly journals Characterization of resistance mechanisms of Enterobacter cloacae Complex co-resistant to carbapenem and colistin

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shixing Liu ◽  
Renchi Fang ◽  
Ying Zhang ◽  
Lijiang Chen ◽  
Na Huang ◽  
...  
Keyword(s):  
Lipid A ◽  
Efflux Pump ◽  
Resistance Mechanism ◽  
Carbapenem Resistance ◽  
Enterobacter Cloacae ◽  
Resistance Mechanisms ◽  
Colistin Resistance ◽  
Carbapenem Resistant ◽  
Horizontal Spread

Abstract Background The emergence of carbapenem-resistant and colistin-resistant ECC pose a huge challenge to infection control. The purpose of this study was to clarify the mechanism of the carbapenems and colistin co-resistance in Enterobacter cloacae Complex (ECC) strains. Results This study showed that the mechanisms of carbapenem resistance in this study are: 1. Generating carbapenemase (7 of 19); 2. The production of AmpC or ESBLs combined with decreased expression of out membrane protein (12 of 19). hsp60 sequence analysis suggested 10 of 19 the strains belong to colistin hetero-resistant clusters and the mechanism of colistin resistance is increasing expression of acrA in the efflux pump AcrAB-TolC alone (18 of 19) or accompanied by a decrease of affinity between colistin and outer membrane caused by the modification of lipid A (14 of 19). Moreover, an ECC strain co-harboring plasmid-mediated mcr-4.3 and blaNDM-1 has been found. Conclusions This study suggested that there is no overlap between the resistance mechanism of co-resistant ECC strains to carbapenem and colistin. However, the emergence of strain co-harboring plasmid-mediated resistance genes indicated that ECC is a potential carrier for the horizontal spread of carbapenems and colistin resistance.

scholarly journals Prevalence and characterization of extended spectrum beta-lactamase-producing Enterobacter cloacae strains in Algeria

2013 ◽  
Vol 7 (11) ◽  
pp. 804-811 ◽  
Author(s):  
Sabrina Nedjai ◽  
Abouddihaj Barguigua ◽  
Nassima Djahmi ◽  
Loubna Jamali ◽  
Khalid Zerouali ◽  
...  
Keyword(s):  
Enterobacter Cloacae ◽  
Dilution Method ◽  
Agar Dilution Method ◽  
Extended Spectrum Beta Lactamase ◽  
Agar Dilution ◽  
Synergy Test ◽  
High Level ◽  
Genomic Typing ◽  
Microbiological Data

Introduction: Expended spectrum β-lactamase (ESBL)-producing Enterobacter cloacae is an important nosocomial pathogen. In this study, the prevalence and the molecular epidemiology of ESBL producing E. cloacae strains isolated from various hospitals in Annaba, Algeria were investigated. Methodology: The study involved 63 isolates of E. cloacae obtained during 2009 at the four hospitals in Annaba. The detection of ESBL was performed using the double-disk synergy test and the combined disk test. Minimum inhibitory concentrations (MICs) were determined using the agar dilution method. The presence of blaCTX-M, blaSHV, blaTEM, and blaDHA β-lactamase genes was evaluated by PCR, and genomic typing was determined by pulsed-field gel electrophoresis (PFGE) analysis. The clinical and microbiological data were entered into the EpiI Info database. Results: Thirty isolates (47.6%) had an ESBL phenotype. BlaCTX-M group1 (76%); blaTEM (70%) were the most prevalent, followed by blaDHA (16.6%) and blaSHV (10%). Eighteen strains expressed at least two bla genes. MICs revealed a high level of resistance to cefotaxime, ceftazidime, and cefepime.  PFGE revealed an epidemic clonal dissemination of these isolates. Various risk factors associated with the occurrence of ESBL-producing E. cloacae were detected. Conclusions: A higher frequency of ESBL-producing isolates and a diversity of β-lactamases were detected among ESBL-producing E. cloacae; these resulted from an epidemic clonal dissemination and high transference of ESBL genes between bacteria in hospital settings. Strict measures will be required to control the further spread of these pathogens in hospital settings.

Characterization of socio-demographics and comorbidities in drug-resistant epilepsy: Review of 62 cases

2017 ◽  
Vol 381 ◽  
pp. 1141
Author(s):  
M. Torres Zambrano ◽  
G. Conde Cardona ◽  
S. Jurado Lopez ◽  
C. Zabala Caraballo ◽  
L. Polo Verbel ◽  
...  
Keyword(s):  
Drug Resistant ◽  
Drug Resistant Epilepsy

Characterization of a lytic EBP bacteriophage with large size genome against Enterobacter cloacae

Apmis ◽  
2021 ◽  
Author(s):  
Muhammad Asif ◽  
Hafsa Naseem ◽  
Iqbal Ahmed Alvi ◽  
Abdul Basit ◽  
Shafiq‐ur‐Rehman
Keyword(s):  
Enterobacter Cloacae ◽  
Large Size
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