Oral vaccination with the porcine circovirus type 2 (PCV‐2) capsid protein expressed by Lactococcus lactis induces a specific immune response against PCV‐2 in mice

2019 ◽  
Vol 128 (1) ◽  
pp. 74-87 ◽  
Author(s):  
L. Wang ◽  
D. Zhao ◽  
B. Sun ◽  
M. Yu ◽  
Y. Wang ◽  
...  
Keyword(s):  
Immune Response ◽  
Capsid Protein ◽  
Lactococcus Lactis ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Specific Immune Response ◽  
Porcine Circovirus ◽  
Oral Vaccination

Characterization of Immune Response of Young Pigs to Porcine Circovirus Type 2 Infection

2000 ◽  
Vol 13 (2) ◽  
pp. 143-153 ◽  
Author(s):  
ROMAN M. POGRANICHNYY ◽  
KYOUNG-JIN YOON ◽  
PERRY A. HARMS ◽  
SABRINA L. SWENSON ◽  
JEFFREY J. ZIMMERMAN ◽  
...  
Keyword(s):  
Immune Response ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Porcine Circovirus ◽  
Young Pigs

Comparing the efficiency of different Escherichia coli strains in producing recombinant capsid protein of porcine circovirus type 2

2020 ◽  
Vol 52 ◽  
pp. 101556 ◽  
Author(s):  
Vishal Rai ◽  
Vikramaditya Upmanyu ◽  
Gulam Mohd ◽  
Ravi Kumar ◽  
Sanganagouda Koppad ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Capsid Protein ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Porcine Circovirus

Systemic immune response of gnotobiotic mice infected with porcine circovirus type 2 after administration of Lactobacillus reuteri L26 Biocenol™

2018 ◽  
Vol 9 (6) ◽  
pp. 951-961
Author(s):  
D. Mudroňová ◽  
V. Karaffová ◽  
T. Csank ◽  
J. Király ◽  
V. Revajová ◽  
...  
Keyword(s):  
Immune Response ◽  
Lactobacillus Reuteri ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Porcine Circovirus ◽  
Control Group ◽  
Intestinal Immunity ◽  
Systemic Immune Response ◽  
Gnotobiotic Mice

In our previous study we confirmed an antiviral activity of probiotic Lactobacillus reuteri L26 which was mediated by stimulation of local intestinal immunity. The aim of this paper was to evaluate the influence of L. reuteri L26 on the systemic immune response in gnotobiotic mice infected with porcine circovirus type 2 (PCV2). A total of 30 germ-free mice were divided into 3 groups and animals in noninfected and infected control groups (NC and IC; n=10) received sterile de Man-Rogosa-Sharpe broth for 7 days and animals in experimental group L+PCV (n=10) were inoculated with L. reuteri L26. Subsequently, mice in L+PCV and IC groups were infected with PCV2; however, mice in the control group received virus cultivation medium (mock). The results showed an increase of percentage of cytotoxic cells (CD8+ and CD49b+CD8-) and oxidative burst of phagocytes, up-regulation of the gene expression of RANTES, granulocyte-macrophage colony-stimulating factor, interferon-γ and immunoglobulin A in blood above all in the later phase of infection (14 dpi) in L+PCV group accompanied by higher load of PCV2 in the serum. These findings indicate that L. reuteri L26 has a potential to induce systemic immune reaction, but in gnotobiotic mice immune stimulation can increase virus replication.

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