Correlation Between Type of Adaptive Immune Response Against Porcine Circovirus Type 2 and Level of Virus Replication

2005 ◽  
Vol 18 (2) ◽  
pp. 333-341 ◽  
Author(s):  
P. Meerts ◽  
S. Van Gucht ◽  
E. Cox ◽  
A. Vandebosch ◽  
H.J. Nauwynck
Keyword(s):  
Immune Response ◽  
Virus Replication ◽  
Adaptive Immune Response ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Porcine Circovirus ◽  
Adaptive Immune

scholarly journals Cellular adaptive immune response against porcine circovirus type 2 in subclinically infected pigs

2009 ◽  
Vol 5 (1) ◽  
pp. 45 ◽  
Author(s):  
Esther Steiner ◽  
Carole Balmelli ◽  
Heidi Gerber ◽  
Artur Summerfield ◽  
Kenneth McCullough
Keyword(s):  
Immune Response ◽  
Adaptive Immune Response ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Porcine Circovirus ◽  
Adaptive Immune

Characterization of Immune Response of Young Pigs to Porcine Circovirus Type 2 Infection

2000 ◽  
Vol 13 (2) ◽  
pp. 143-153 ◽  
Author(s):  
ROMAN M. POGRANICHNYY ◽  
KYOUNG-JIN YOON ◽  
PERRY A. HARMS ◽  
SABRINA L. SWENSON ◽  
JEFFREY J. ZIMMERMAN ◽  
...  
Keyword(s):  
Immune Response ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Porcine Circovirus ◽  
Young Pigs

Systemic immune response of gnotobiotic mice infected with porcine circovirus type 2 after administration of Lactobacillus reuteri L26 Biocenol™

2018 ◽  
Vol 9 (6) ◽  
pp. 951-961
Author(s):  
D. Mudroňová ◽  
V. Karaffová ◽  
T. Csank ◽  
J. Király ◽  
V. Revajová ◽  
...  
Keyword(s):  
Immune Response ◽  
Lactobacillus Reuteri ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Porcine Circovirus ◽  
Control Group ◽  
Intestinal Immunity ◽  
Systemic Immune Response ◽  
Gnotobiotic Mice

In our previous study we confirmed an antiviral activity of probiotic Lactobacillus reuteri L26 which was mediated by stimulation of local intestinal immunity. The aim of this paper was to evaluate the influence of L. reuteri L26 on the systemic immune response in gnotobiotic mice infected with porcine circovirus type 2 (PCV2). A total of 30 germ-free mice were divided into 3 groups and animals in noninfected and infected control groups (NC and IC; n=10) received sterile de Man-Rogosa-Sharpe broth for 7 days and animals in experimental group L+PCV (n=10) were inoculated with L. reuteri L26. Subsequently, mice in L+PCV and IC groups were infected with PCV2; however, mice in the control group received virus cultivation medium (mock). The results showed an increase of percentage of cytotoxic cells (CD8+ and CD49b+CD8-) and oxidative burst of phagocytes, up-regulation of the gene expression of RANTES, granulocyte-macrophage colony-stimulating factor, interferon-γ and immunoglobulin A in blood above all in the later phase of infection (14 dpi) in L+PCV group accompanied by higher load of PCV2 in the serum. These findings indicate that L. reuteri L26 has a potential to induce systemic immune reaction, but in gnotobiotic mice immune stimulation can increase virus replication.

scholarly journals Host immune response to infection with porcine circoviruses

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Ruihan Shi ◽  
Lei Hou ◽  
Jue Liu
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Inflammatory Responses ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Immune Defense ◽  
Porcine Circovirus ◽  
Future Research ◽  
Host Immune System

AbstractPorcine circovirus type 2 (PCV2), which serves as a major causative agent of PCV2-associated diseases and causes severe loss to the pig industry worldwide, can dysregulate the immune response and induce immunosuppression in PCV2-infected pigs. Similar to PCV2, porcine circovirus type 3 (PCV3), a newly identified swine circovirus which might be closely associated with porcine dermatitis and nephropathy syndrome, reproductive disorder, and multisystemic inflammatory responses, also interferes with host immune defense. Interaction between host immune system and PCVs is considered to be a crucial determinant of pathogenicity in pigs. Here, we sought to briefly discuss the current knowledge regarding the interaction of porcine circovirus type 2 and/or 3 with host immune cells and immune responses to better depict the viral immunomodulatory capacity, pathogenic mechanisms, and the future research direction in host immune responses to infection with PCV2 and PCV3.

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