Biotransformation of ginsenoside Rb1 to ginsenoside Rg3 by endophytic bacterium Burkholderia sp. GE 17-7 isolated from Panax ginseng

2017 ◽  
Vol 122 (6) ◽  
pp. 1579-1585 ◽  
Author(s):  
Y. Fu ◽  
Z.-H. Yin ◽  
C.-Y. Yin
Keyword(s):  
Panax Ginseng ◽  
Endophytic Bacterium ◽  
Ginsenoside Rb1 ◽  
Ginsenoside Rg3

Ginsenoside Rb1, A Major Saponin from Panax ginseng, Exerts Protective Effects Against Acetaminophen-Induced Hepatotoxicity in Mice

2019 ◽  
Vol 47 (08) ◽  
pp. 1815-1831 ◽  
Author(s):  
Shen Ren ◽  
Jing Leng ◽  
Xing-Yue Xu ◽  
Shuang Jiang ◽  
Ying-Ping Wang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Panax Ginseng ◽  
Inflammatory Responses ◽  
Interleukin 1 ◽  
Protective Effects ◽  
Ginsenoside Rb1 ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Oxide Synthase

Acute liver injury (ALI) induced by acetaminophen (APAP) is the main cause of drug-induced liver injury. Previous reports indicated liver failure could be alleviated by saponins (ginsenosides) from Panax ginseng against APAP-induced inflammatory responses in vivo. However, validation towards ginsenoside Rb1 as a major and marker saponin may protect liver from APAP-induced ALI and its mechanisms are poorly elucidated. In this study, the protective effects and the latent mechanisms of Rb1 action against APAP-induced hepatotoxicity were investigated. Rb1 was administered orally with 10[Formula: see text]mg/kg and 20[Formula: see text]mg/kg daily for 1 week before a single injection of APAP (250[Formula: see text]mg/kg, i.p.) 1[Formula: see text]h after the last treatment of Rb1. Serum alanine/aspartate aminotransferases (ALT/AST), liver glutathione (GSH) depletion, as well as the inflammatory cytokines, such as tumor necrosis factor-[Formula: see text] (TNF-[Formula: see text]), interleukin-1[Formula: see text] (IL-1[Formula: see text]), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), were analyzed to indicate the underlying protective effects of Rb1 against APAP-induced hepatotoxicity with significant inflammatory responses. Histological examination further proved Rb1’s protective effects. Importantly, Rb1 mitigated the changes in the phosphorylation of MAPK and PI3K/Akt, as well as its downstream factor NF-[Formula: see text]B. In conclusion, experimental data clearly demonstrated that Rb1 exhibited a remarkable liver protective effect against APAP-induced ALI, partly through regulating MAPK and PI3K/Akt signaling pathways-mediated inflammatory responses.

Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514

2008 ◽  
Vol 69 (1) ◽  
pp. 218-224 ◽  
Author(s):  
Le-Qin Cheng ◽  
Ju Ryun Na ◽  
Myun Ho Bang ◽  
Myung Kyum Kim ◽  
Deok-Chun Yang
Keyword(s):  
Ginsenoside Rb1 ◽  
Ginsenoside Rg3

scholarly journals Complete Genome Sequence of the Endophytic Bacterium Bacillus cereus PgBE311, Isolated from Panax ginseng

2018 ◽  
Vol 7 (21) ◽  
Author(s):  
Chi Eun Hong ◽  
Jang Uk Kim ◽  
Jung Woo Lee ◽  
Kyong Hwan Bang ◽  
Ick-Hyun Jo
Keyword(s):  
Bacillus Cereus ◽  
Panax Ginseng ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Fungal Pathogens ◽  
Endophytic Bacterium ◽  
Content Type ◽  
Cylindrocarpon Destructans ◽  
Bacterium Bacillus

Bacillus cereus PgBE311, isolated from the root tissue of a 5-year-old Panax ginseng plant, showed activities against the fungal pathogens Cylindrocarpon destructans and Botrytis cinerea. Here, we report the genome sequence of B. cereus PgBE311.

scholarly journals Anti-Angiogenic Properties of Ginsenoside Rg3

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4905
Author(s):  
Maryam Nakhjavani ◽  
Eric Smith ◽  
Amanda R. Townsend ◽  
Timothy J. Price ◽  
Jennifer E. Hardingham
Keyword(s):  
Effective Dose ◽  
Panax Ginseng ◽  
Dose Range ◽  
Ginsenoside Rg3 ◽  
Anti Cancer

Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One facet of the anti-cancer properties of Rg3 is the anti-angiogenic action. This review describes the controversies on the effects and effective dose range of Rg3, summarizes the evidence on the efficacy of Rg3 on angiogenesis, and raises the possibility that Rg3 is a prodrug.

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