A case of vancomycin-induced linear IgA bullous dermatosis with circulating IgA antibodies to the NC16a domain of BP180

2013 ◽  
Vol 53 (3) ◽  
pp. e207-e209 ◽  
Author(s):  
Saki Tashima ◽  
Keisuke Konishi ◽  
Hiroshi Koga ◽  
Takashi Hashimoto
Keyword(s):  
Bullous Dermatosis ◽  
Iga Antibodies ◽  
Linear Iga Bullous Dermatosis

scholarly journals Linear IGA bullous dermatosis potentially triggered by vaccination

2022 ◽  
Vol 36 ◽  
pp. 205873842110212
Author(s):  
Alberto Corrà ◽  
Veronica Bonciolini ◽  
Lavinia Quintarelli ◽  
Alice Verdelli ◽  
Marzia Caproni
Keyword(s):  
Basement Membrane Zone ◽  
Dermoepidermal Junction ◽  
Pathogenetic Role ◽  
Autoimmune Blistering Disease ◽  
Bullous Dermatosis ◽  
Iga Antibodies ◽  
Blistering Disease ◽  
Adults And Children ◽  
Linear Iga Bullous Dermatosis

Linear IgA bullous dermatosis (LABD) is a mucocutaneous autoimmune blistering disease affecting both adults and children. It is caused by IgA antibodies targeting multiple antigens along the basement membrane zone, leading to disruption of dermoepidermal junction and development of bullous lesions which often presents in characteristic arrangement. Although most LABD cases have been reported to be idiopathic, different triggers have been described, including several drugs and infection. However, the occurrence of vaccine-induced cases of LABD is not widely known and accepted due to the few reports available. We present two cases of LABD occurred following different triggers, rising the suspicion for a possible pathogenetic role of vaccines.

scholarly journals IgA Antibodies of Linear IgA Bullous Dermatosis Recognize the 15th Collagenous Domain of BP180

2000 ◽  
Vol 115 (6) ◽  
pp. 1164-1166 ◽  
Author(s):  
Zhuxiang Nie ◽  
Yoshiko Nagata ◽  
Sohaola Joubeh ◽  
Takashi Hashimoto ◽  
Yoshiaki Hirako ◽  
...  
Keyword(s):  
Bullous Dermatosis ◽  
Iga Antibodies ◽  
Linear Iga Bullous Dermatosis ◽  
Collagenous Domain

scholarly journals Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Lilla Mihályi ◽  
Mária Kiss ◽  
Attila Dobozy ◽  
Lajos Kemény ◽  
Sándor Husz
Keyword(s):  
Bullous Pemphigoid ◽  
Clinical Relevance ◽  
Distinct Entity ◽  
Diphenyl Sulfone ◽  
Bullous Dermatosis ◽  
Iga Pemphigus ◽  
Iga Antibodies ◽  
Linear Iga Bullous Dermatosis ◽  
Perilesional Skin ◽  
Diamino Diphenyl Sulfone

The authors present their experience related to the diagnosis, treatment, and followup of 431 patients with bullous pemphigoid, 14 patients with juvenile bullous pemphigoid, and 273 patients with pemphigus. The detection of autoantibodies plays an outstanding role in the diagnosis and differential diagnosis. Paraneoplastic pemphigoid is suggested to be a distinct entity from the group of bullous pemphigoid in view of the linear C3 deposits along the basement membrane of the perilesional skin and the “ladder” configuration of autoantibodies demonstrated by western blot analysis. It is proposed that IgA pemphigoid should be differentiated from the linear IgA dermatoses. Immunosuppressive therapy is recommended in which the maintenance dose of corticosteroid is administered every second day, thereby reducing the side effects of the corticosteroids. Following the detection of IgA antibodies (IgA pemphigoid, linear IgA bullous dermatosis, and IgA pemphigus), diamino diphenyl sulfone (dapsone) therapy is preferred alone or in combination. The clinical relevance of autoantibodies in patients with autoimmune bullous dermatosis is stressed.

scholarly journals Vancomycin‐induced linear IgA bullous dermatosis ( LABD )—an atypical presentation

2019 ◽  
Vol 7 (5) ◽  
pp. 1091-1093 ◽  
Author(s):  
Lorena Visentainer ◽  
Juliana Yumi Massuda ◽  
Maria Letícia Cintra ◽  
Renata Ferreira Magalhães
Keyword(s):  
Atypical Presentation ◽  
Bullous Dermatosis ◽  
Linear Iga Bullous Dermatosis
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