scholarly journals Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Lilla Mihályi ◽  
Mária Kiss ◽  
Attila Dobozy ◽  
Lajos Kemény ◽  
Sándor Husz
Keyword(s):  
Bullous Pemphigoid ◽  
Clinical Relevance ◽  
Distinct Entity ◽  
Diphenyl Sulfone ◽  
Bullous Dermatosis ◽  
Iga Pemphigus ◽  
Iga Antibodies ◽  
Linear Iga Bullous Dermatosis ◽  
Perilesional Skin ◽  
Diamino Diphenyl Sulfone

The authors present their experience related to the diagnosis, treatment, and followup of 431 patients with bullous pemphigoid, 14 patients with juvenile bullous pemphigoid, and 273 patients with pemphigus. The detection of autoantibodies plays an outstanding role in the diagnosis and differential diagnosis. Paraneoplastic pemphigoid is suggested to be a distinct entity from the group of bullous pemphigoid in view of the linear C3 deposits along the basement membrane of the perilesional skin and the “ladder” configuration of autoantibodies demonstrated by western blot analysis. It is proposed that IgA pemphigoid should be differentiated from the linear IgA dermatoses. Immunosuppressive therapy is recommended in which the maintenance dose of corticosteroid is administered every second day, thereby reducing the side effects of the corticosteroids. Following the detection of IgA antibodies (IgA pemphigoid, linear IgA bullous dermatosis, and IgA pemphigus), diamino diphenyl sulfone (dapsone) therapy is preferred alone or in combination. The clinical relevance of autoantibodies in patients with autoimmune bullous dermatosis is stressed.

scholarly journals Linear IGA bullous dermatosis potentially triggered by vaccination

2022 ◽  
Vol 36 ◽  
pp. 205873842110212
Author(s):  
Alberto Corrà ◽  
Veronica Bonciolini ◽  
Lavinia Quintarelli ◽  
Alice Verdelli ◽  
Marzia Caproni
Keyword(s):  
Basement Membrane Zone ◽  
Dermoepidermal Junction ◽  
Pathogenetic Role ◽  
Autoimmune Blistering Disease ◽  
Bullous Dermatosis ◽  
Iga Antibodies ◽  
Blistering Disease ◽  
Adults And Children ◽  
Linear Iga Bullous Dermatosis

Linear IgA bullous dermatosis (LABD) is a mucocutaneous autoimmune blistering disease affecting both adults and children. It is caused by IgA antibodies targeting multiple antigens along the basement membrane zone, leading to disruption of dermoepidermal junction and development of bullous lesions which often presents in characteristic arrangement. Although most LABD cases have been reported to be idiopathic, different triggers have been described, including several drugs and infection. However, the occurrence of vaccine-induced cases of LABD is not widely known and accepted due to the few reports available. We present two cases of LABD occurred following different triggers, rising the suspicion for a possible pathogenetic role of vaccines.

Other Vesiculobullous Diseases

2020 ◽  
Author(s):  
Aakaash Varma ◽  
Annette Czernik ◽  
Jacob Levitt
Keyword(s):  
Bullous Pemphigoid ◽  
Epidermolysis Bullosa ◽  
Tissue Transglutaminase ◽  
Direct Immunofluorescence ◽  
Cicatricial Pemphigoid ◽  
Positive Serology ◽  
Fixed Drug Eruption ◽  
Varicella Zoster ◽  
Bullous Dermatosis ◽  
Linear Iga Bullous Dermatosis

Less common immunobullous diseases include cicatricial pemphigoid, epidermolysis bullosa acquisita, and linear IgA bullous dermatosis. Diagnosis of these entities are made through direct immunofluorescence, sometimes requires salt-split skin, as well as, in the case of cicatricial pemphigoid, mucosal scarring. As in pemphigus vulgaris and bullous pemphigoid, common therapies include rituximab, prednisone, and IVIg. Dapsone can be particularly effective in linear IgA bullous dermatosis and bullous lupus. Dermatitis herpetiformis is a rare cutaneous manifestation of gluten sensitivity, characterized by pruritic vesicles on extensor surfaces, that responds to dapsone and gluten avoidance. This diagnosis is confirmed with biopsy and positive serology for anti-tissue transglutaminase IgA. Blistering hypersensitivity reactions include TEN, SJS, erythema multiforme, and fixed drug eruption. All are characterized by varying degrees of keratinocyte necrosis. Common to the management of all include cessation of the offending agent. TEN can be managed by cyclosporine, TNF-inhibition, or—more controversially—IVIg. SJS can be effectively managed with systemic steroids. EM responds variably to a number of agents, including antiviral nucleoside analogues, prednisone, thalidomide, apremilast, and tofacitinib. Infectious causes of blisters include Staphylococcus aureus, HSV, and varicella zoster virus. Epidermolysis bullosa comprises a variety of genetically defective structural proteins of the skin. Recessive variants and those affecting deeper proteins carry more severe phenotypes. Management is best achieved at specialty centers and involves careful wound care as well as prevention of friction. Gene therapy is on the horizon for these disorders. Other blistering entities, mechanical or inflammatory in nature, are also discussed at the end of this chapter. This review contains 13 figures, 1 table, and 86 references. Keywords: Blisters, bullae, bullous, pemphigoid, necrolysis

IgA pemphigus and linear IgA bullous dermatosis in a patient with ulcerative colitis

2020 ◽  
Vol 61 (4) ◽  
Author(s):  
Carli P Whittington ◽  
Meagan M Huelsman ◽  
Ryan R Bogner ◽  
Jeffrey P Callen
Keyword(s):  
Ulcerative Colitis ◽  
Bullous Dermatosis ◽  
Iga Pemphigus ◽  
Linear Iga Bullous Dermatosis

scholarly journals IgA Antibodies of Linear IgA Bullous Dermatosis Recognize the 15th Collagenous Domain of BP180

2000 ◽  
Vol 115 (6) ◽  
pp. 1164-1166 ◽  
Author(s):  
Zhuxiang Nie ◽  
Yoshiko Nagata ◽  
Sohaola Joubeh ◽  
Takashi Hashimoto ◽  
Yoshiaki Hirako ◽  
...  
Keyword(s):  
Bullous Dermatosis ◽  
Iga Antibodies ◽  
Linear Iga Bullous Dermatosis ◽  
Collagenous Domain
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