The effect of dental bleaching on pulpal tissue response in a diabetic animal model: a study of immunoregulatory cytokines

2017 ◽  
Vol 51 (3) ◽  
pp. 347-356 ◽  
Author(s):  
L. L. Ferreira ◽  
J. E. Gomes-Filho ◽  
F. Benetti ◽  
M. Carminatti ◽  
E. Ervolino ◽  
...  
Keyword(s):  
Animal Model ◽  
Diabetic Animal ◽  
Tissue Response ◽  
Dental Bleaching ◽  
Immunoregulatory Cytokines

The effect of dental bleaching on pulpal tissue response in a diabetic animal model

2016 ◽  
Vol 50 (8) ◽  
pp. 790-798 ◽  
Author(s):  
L. T. A. Cintra ◽  
L. L. Ferreira ◽  
F. Benetti ◽  
A. A. Gastélum ◽  
J. E. Gomes-Filho ◽  
...  
Keyword(s):  
Animal Model ◽  
Diabetic Animal ◽  
Tissue Response ◽  
Dental Bleaching

Development of Diabetic Animal Model via Insulin Glargine Induction

2021 ◽  
Vol 15 (2) ◽  
pp. 67-74
Author(s):  
Tyas Rini Saras ◽  
I. Gusti Ayu Agung ◽  
Silvana Tana
Keyword(s):  
Animal Model ◽  
Insulin Glargine ◽  
Diabetic Animal

scholarly journals Local Tissue Response to Subcutaneous Administration of Ceftriaxone in an Animal Model

2019 ◽  
Vol 64 (3) ◽  
Author(s):  
Vincent H. Tam ◽  
Daniel N. Cohen ◽  
Kimberly R. Ledesma ◽  
Bobby Guillory ◽  
Katrina Chan ◽  
...  
Keyword(s):  
Animal Model ◽  
Potassium Chloride ◽  
Subcutaneous Administration ◽  
Pharmaceutical Formulations ◽  
Tissue Response ◽  
Sprague Dawley ◽  
Local Tolerability ◽  
Local Inflammatory Response ◽  
Local Tissue ◽  
Thickness Skin

ABSTRACT Subcutaneous administration is a novel way to deliver antibiotics for an infection, but intolerability has been reported. Evaluating the local tolerability of subcutaneously administered antibiotics is not standardized. The goal of this study was to develop an animal model to assess the subcutaneous administration of ceftriaxone. Sprague-Dawley rats were given daily subcutaneous injections for 12 days. The back of each animal was divided into 4 quadrants, with injections rotating each day among the quadrants. Ceftriaxone (1,000 mg/kg of body weight daily) was given in different concentrations and durations. Normal saline and potassium chloride solutions (2 meq/2 ml) were used as negative and positive controls, respectively. After the treatment course, skin samples were biopsied, and the local inflammatory response was assessed histologically using a semiquantitative scoring system. The histopathology scores were compared using a Kruskal-Wallis test. Injections with potassium chloride resulted in full-thickness skin necrosis with subcutaneous atrophy that was not seen in the saline-injected animals; inflammation of the muscular panniculus was observed, with various degrees of myocyte injury. Serosanguinous cavity formation in the subcutaneous compartment was observed when ceftriaxone (125 mg/ml) was given as a bolus injection, but the extent of the local tissue response was remarkably reduced when the same ceftriaxone dose was given at a lower concentration (25 mg/ml) over 120 min (P = 0.63, compared to saline controls). At a low concentration, ceftriaxone infusion was found to be well tolerated in this animal tissue necrosis model. If validated, the model could be an instrumental platform to evaluate different pharmaceutical formulations for subcutaneous delivery.

In Vivo Characterization of Corneal Changes in a Type 1 Diabetic Animal Model

2019 ◽  
Vol 45 (3) ◽  
pp. 823-832
Author(s):  
Miguel Caixinha ◽  
Pedro Oliveira ◽  
Inês D. Aires ◽  
António Francisco Ambrósio ◽  
Ana Raquel Santiago ◽  
...  
Keyword(s):  
Animal Model ◽  
Diabetic Animal ◽  
In Vivo Characterization

Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic animal model

2018 ◽  
Vol 102 ◽  
pp. 140-146 ◽  
Author(s):  
Kanwal Rehman ◽  
Kiran Saeed ◽  
Syeda Mehak Munawar ◽  
Muhammad Sajid Hamid Akash
Keyword(s):  
Animal Model ◽  
Diabetic Animal

scholarly journals Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor

2018 ◽  
Vol 11 (2) ◽  
pp. 193-204 ◽  
Author(s):  
Mikael Montelius ◽  
Johan Spetz ◽  
Oscar Jalnefjord ◽  
Evelin Berger ◽  
Ola Nilsson ◽  
...  
Keyword(s):  
Animal Model ◽  
Small Intestine ◽  
Neuroendocrine Tumor ◽  
Tumor Tissue ◽  
Tissue Response

scholarly journals Everolimus-Eluting Stents Improve Vascular Response in a Diabetic Animal Model

2014 ◽  
Vol 7 (4) ◽  
pp. 526-532 ◽  
Author(s):  
Anwer Habib ◽  
Vinit Karmali ◽  
Michael C. John ◽  
Rohini Polavarapu ◽  
Gaku Nakazawa ◽  
...  
Keyword(s):  
Animal Model ◽  
Diabetic Animal ◽  
Vascular Response
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