scholarly journals Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor

2018 ◽  
Vol 11 (2) ◽  
pp. 193-204 ◽  
Author(s):  
Mikael Montelius ◽  
Johan Spetz ◽  
Oscar Jalnefjord ◽  
Evelin Berger ◽  
Ola Nilsson ◽  
...  
Keyword(s):  
Animal Model ◽  
Small Intestine ◽  
Neuroendocrine Tumor ◽  
Tumor Tissue ◽  
Tissue Response

508Irradiation induced early side effects in the small intestine of an animal model after photon and neutron irradiation

1996 ◽  
Vol 40 ◽  
pp. S130
Author(s):  
F.-J. Prott ◽  
H. Eversmann ◽  
R.R. Lehmann ◽  
U. Haverkamp ◽  
O. Micke ◽  
...  
Keyword(s):  
Animal Model ◽  
Small Intestine ◽  
Side Effects ◽  
Neutron Irradiation

The effect of dental bleaching on pulpal tissue response in a diabetic animal model: a study of immunoregulatory cytokines

2017 ◽  
Vol 51 (3) ◽  
pp. 347-356 ◽  
Author(s):  
L. L. Ferreira ◽  
J. E. Gomes-Filho ◽  
F. Benetti ◽  
M. Carminatti ◽  
E. Ervolino ◽  
...  
Keyword(s):  
Animal Model ◽  
Diabetic Animal ◽  
Tissue Response ◽  
Dental Bleaching ◽  
Immunoregulatory Cytokines

A neuroendocrine tumor of the small intestine with a karyotype of 46,XY,t(11;22)

1986 ◽  
Vol 22 (3) ◽  
pp. 211-218 ◽  
Author(s):  
N.V. Vigfusson ◽  
L.J. Allen ◽  
J.H. Phillips ◽  
T. Alschibaja ◽  
W.G. Riches
Keyword(s):  
Small Intestine ◽  
Neuroendocrine Tumor

scholarly journals Neuroendocrine tumor of the small intestine diagnosed with trans-abdominal ultrasonography: A case report

2020 ◽  
Author(s):  
Kazuma Tsujimura ◽  
Yasukatsu Takushi ◽  
Atsushi Nakachi ◽  
Tsuyoshi Teruya ◽  
Kouji Iha
Keyword(s):  
Small Intestine ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Neuroendocrine Tumor ◽  
Clinical Symptoms ◽  
Abdominal Ultrasonography ◽  
Node Metastasis ◽  
Tumor Lesion ◽  
Contrast Enhanced ◽  
Enhanced Computed Tomography

Tumors of the small intestine are rare. In addition, clinical symptoms are nonspecific and neoplasm-related symptoms occur late. We report a case of neuroendocrine tumor (NET) of the small intestine that was diagnosed early with trans-abdominal ultrasonography (US). The patient was a 61-year-old man. Abdominal contrast-enhanced computed tomography (CT) was performed because the patient complained of abdominal pain. The CT showed a tumor lesion in the mesentery. Trans-abdominal US was undertaken to evaluate this tumor lesion, and a tumor lesion of the small intestine was found nearby. A diagnosis of lymph-node metastasis of a small-intestine tumor was made as a preoperative diagnosis. A laparotomy was performed with partial resection of the ileum, together with the small-intestine mesentery including an enlarged lymph node. Histological examination revealed NET of the ileum and lymph-node metastasis. Trans-abdominal US is useful in the diagnosis of small-intestine NET.

scholarly journals Local Tissue Response to Subcutaneous Administration of Ceftriaxone in an Animal Model

2019 ◽  
Vol 64 (3) ◽  
Author(s):  
Vincent H. Tam ◽  
Daniel N. Cohen ◽  
Kimberly R. Ledesma ◽  
Bobby Guillory ◽  
Katrina Chan ◽  
...  
Keyword(s):  
Animal Model ◽  
Potassium Chloride ◽  
Subcutaneous Administration ◽  
Pharmaceutical Formulations ◽  
Tissue Response ◽  
Sprague Dawley ◽  
Local Tolerability ◽  
Local Inflammatory Response ◽  
Local Tissue ◽  
Thickness Skin

ABSTRACT Subcutaneous administration is a novel way to deliver antibiotics for an infection, but intolerability has been reported. Evaluating the local tolerability of subcutaneously administered antibiotics is not standardized. The goal of this study was to develop an animal model to assess the subcutaneous administration of ceftriaxone. Sprague-Dawley rats were given daily subcutaneous injections for 12 days. The back of each animal was divided into 4 quadrants, with injections rotating each day among the quadrants. Ceftriaxone (1,000 mg/kg of body weight daily) was given in different concentrations and durations. Normal saline and potassium chloride solutions (2 meq/2 ml) were used as negative and positive controls, respectively. After the treatment course, skin samples were biopsied, and the local inflammatory response was assessed histologically using a semiquantitative scoring system. The histopathology scores were compared using a Kruskal-Wallis test. Injections with potassium chloride resulted in full-thickness skin necrosis with subcutaneous atrophy that was not seen in the saline-injected animals; inflammation of the muscular panniculus was observed, with various degrees of myocyte injury. Serosanguinous cavity formation in the subcutaneous compartment was observed when ceftriaxone (125 mg/ml) was given as a bolus injection, but the extent of the local tissue response was remarkably reduced when the same ceftriaxone dose was given at a lower concentration (25 mg/ml) over 120 min (P = 0.63, compared to saline controls). At a low concentration, ceftriaxone infusion was found to be well tolerated in this animal tissue necrosis model. If validated, the model could be an instrumental platform to evaluate different pharmaceutical formulations for subcutaneous delivery.

Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model

2018 ◽  
Vol 102 ◽  
pp. S709
Author(s):  
Michele Finotti ◽  
Taras Lysyy ◽  
Maria J Barahona ◽  
Renee M Maina ◽  
Giorgio Caturegli ◽  
...  
Keyword(s):  
Animal Model ◽  
Small Intestine ◽  
Ex Vivo ◽  
Ischemic Injury ◽  
Ex Vivo Perfusion

scholarly journals Neuroendocrine tumor of the small intestine diagnosed with trans-abdominal ultrasonography: A case report

2017 ◽  
Vol 31 ◽  
pp. 75-78
Author(s):  
Kazuma Tsujimura ◽  
Yasukatsu Takushi ◽  
Tsuyoshi Teruya ◽  
Kouji Iha ◽  
Morihito Ota ◽  
...  
Keyword(s):  
Small Intestine ◽  
Case Report ◽  
Neuroendocrine Tumor ◽  
Abdominal Ultrasonography

PL12. Tissue-Engineered Small Intestine and Stomach Demonstrate Features of an Intact Stem Cell Niche in a Large Animal Model

2009 ◽  
Vol 151 (2) ◽  
pp. 279-280
Author(s):  
F.G. Sala ◽  
S. Kunisaki ◽  
E. Ochoa ◽  
J.P. Vacanti ◽  
T.C. Grikscheit
Keyword(s):  
Animal Model ◽  
Small Intestine ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Large Animal Model ◽  
Large Animal ◽  
Cell Niche
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