scholarly journals Comprehensive histological investigation of age‐related changes in dermal extracellular matrix and muscle fibers in the upper lip vermilion

2020 ◽  
Vol 42 (4) ◽  
pp. 359-368
Author(s):  
T. Gomi ◽  
T. Imamura
Keyword(s):  
Extracellular Matrix ◽  
Muscle Fibers ◽  
Histological Investigation ◽  
Upper Lip ◽  
Age Related ◽  
Age Related Changes

scholarly journals Physiology of Vitreous and Vitreomacular Interface and Age-Related Changes

2018 ◽  
pp. 213-219
Keyword(s):  
Extracellular Matrix ◽  
Posterior Vitreous Detachment ◽  
Natural Aging ◽  
Posterior Segment ◽  
Vitreomacular Adhesion ◽  
Vitreoretinal Interface ◽  
Age Related ◽  
Ocular Structure ◽  
Vitreomacular Interface ◽  
Age Related Changes

Vitreous is an important ocular structure in the normal physiology and pathologic conditions of the posterior segment. Vitreous is a gel-like composite structure and forms an extracellular matrix that occupies the biggest space in the eye. The healthy vitreous gel reduces oxygen tension and protects vitreous, retina, and lens from oxidative damage. Vitreous plays an important role in the refraction of the eye, preserving the transparency with regular interaction of the macromolecules contained therein. Vitreous suffer from continuous physical tension and this results in important changes. Particularly age-related degeneration in the structure of the vitreous gel leads to a decrease in vitreoretinal adhesion. As part of natural aging, the posterior vitreous detachment process may become pathologic when the vitreoretinal interface weakens simultaneously with vitreous liquefaction. In this process, vision-threatening diseases such as vitreomacular adhesion, vitreomacular traction, and macula hole may appear.

Age-Related Changes in the Extracellular Matrix of the Human Optic Nerve Head

1989 ◽  
Vol 107 (5) ◽  
pp. 476-484 ◽  
Author(s):  
M. Rosario Hernandez ◽  
Xing Xing Luo ◽  
Wieslawa Andrzejewska ◽  
Arthur H. Neufeld
Keyword(s):  
Extracellular Matrix ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Age Related ◽  
Human Optic Nerve ◽  
Age Related Changes

scholarly journals Age-related changes in the vasculature of the dermis of the upper lip vermilion

Aging ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 3551-3560 ◽  
Author(s):  
Takamasa Gomi ◽  
Toru Imamura
Keyword(s):  
Upper Lip ◽  
Age Related ◽  
Age Related Changes

The Aging Lip: A Comparative Histological Analysis of Age-Related Changes in the Upper Lip Complex

2009 ◽  
Vol 124 (2) ◽  
pp. 624-628 ◽  
Author(s):  
Vincenzo Penna ◽  
G -Björn Stark ◽  
Steffen U. Eisenhardt ◽  
Holger Bannasch ◽  
Niklas Iblher
Keyword(s):  
Histological Analysis ◽  
Upper Lip ◽  
Age Related ◽  
Age Related Changes

Age-related changes of DRG neuronal attachment to extracellular matrix proteins in vitro

Neuroreport ◽  
1993 ◽  
Vol 4 (6) ◽  
pp. 663-666 ◽  
Author(s):  
Kazunori Sango ◽  
Hidenori Horie ◽  
Shuji Inoue ◽  
Yutaro Takamura ◽  
Toshifumi Takenaka
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Age Related ◽  
Age Related Changes

scholarly journals Alterations of Extracellular Matrix Mechanical Properties Contribute to Age-Related Functional Impairment of Human Skeletal Muscles

2020 ◽  
Vol 21 (11) ◽  
pp. 3992 ◽  
Author(s):  
Piero Pavan ◽  
Elena Monti ◽  
Michela Bondí ◽  
Chenglei Fan ◽  
Carla Stecco ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Skeletal Muscles ◽  
Sarcomere Length ◽  
Muscle Fibers ◽  
Muscle Area ◽  
Age Related ◽  
Collagen Accumulation ◽  
The Difference ◽  
Picrosirius Red ◽  
Human Skeletal Muscles

Aging of human skeletal muscles is associated with increased passive stiffness, but it is still debated whether muscle fibers or extracellular matrix (ECM) are the determinants of such change. To answer this question, we compared the passive stress generated by elongation of fibers alone and arranged in small bundles in young healthy (Y: 21 years) and elderly (E: 67 years) subjects. The physiological range of sarcomere length (SL) 2.5–3.3 μm was explored. The area of ECM between muscle fibers was determined on transversal sections with picrosirius red, a staining specific for collagen fibers. The passive tension of fiber bundles was significantly higher in E compared to Y at all SL. However, the resistance to elongation of fibers alone was not different between the two groups, while the ECM contribution was significantly increased in E compared to Y. The proportion of muscle area occupied by ECM increased from 3.3% in Y to 8.2% in E. When the contribution of ECM to bundle tension was normalized to the fraction of area occupied by ECM, the difference disappeared. We conclude that, in human skeletal muscles, the age-related reduced compliance is due to an increased stiffness of ECM, mainly caused by collagen accumulation.

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