Significance of pretransplant abstinence on harmful alcohol relapse after liver transplantation for alcoholic cirrhosis in Japan

2014 ◽  
Vol 44 (14) ◽  
pp. E428-E436 ◽  
Author(s):  
Hiroto Egawa ◽  
Yoshihide Ueda ◽  
Naoki Kawagishi ◽  
Takahito Yagi ◽  
Hiroyuki Kimura ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Alcoholic Cirrhosis ◽  
Alcohol Relapse ◽  
Harmful Alcohol

scholarly journals Risk factors for alcohol relapse after liver transplantation for alcoholic cirrhosis in Japan

2014 ◽  
Vol 20 (3) ◽  
pp. 298-310 ◽  
Author(s):  
Hiroto Egawa ◽  
Katsuji Nishimura ◽  
Satoshi Teramukai ◽  
Masakazu Yamamoto ◽  
Koji Umeshita ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Alcoholic Cirrhosis ◽  
Alcohol Relapse

scholarly journals Alcoholic cirrhosis is a good indication for liver transplantation, even for cases of recidivism

Gut ◽  
1999 ◽  
Vol 45 (3) ◽  
pp. 421-426 ◽  
Author(s):  
G-P Pageaux ◽  
J Michel ◽  
V Coste ◽  
P Perney ◽  
P Possoz ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Survival Rates ◽  
Alcoholic Cirrhosis ◽  
Immunosuppressive Regimen ◽  
Recidivism Rate ◽  
Ethical Considerations ◽  
Alcohol Relapse ◽  
Two Factors ◽  
Alcoholic Disease

BACKGROUND/AIMSAlcoholic cirrhosis remains a controversial indication for liver transplantation, mainly because of ethical considerations related to the shortage of donor livers. The aim of this study was to review experience to date, focusing on survival rates and complications, and the effect of alcohol relapse on outcome and alterations in marital and socioprofessional status.METHODSThe results for 53 patients transplanted for alcoholic cirrhosis between 1989 and 1994 were compared with those for 48 patients transplanted for non-alcoholic liver disease. The following variables were analysed: survival, rejection, infection, cancer, retransplantation, employment and marital status, alcoholic recurrence. The same variables were compared between alcohol relapsers and non-relapsers.RESULTSRecovery of employment was the only significantly different variable between alcoholic (30%) and non-alcoholic patients (60%). Two factors influenced survival in the absence of alcohol recidivism: age and abstinence before transplantation. For all other variables, there were no differences between alcoholic and non-alcoholic patients, and, within the alcoholic group, between relapsers and non-relapsers. The recidivism rate was 32%.CONCLUSIONThe data indicate that liver transplantation is justified for alcoholic cirrhosis, even in cases of recidivism, which did no affect survival and compliance with the immunosuppressive regimen. These good results should help in educating the general population about alcoholic disease.

181Carbohydrate deficient transferrin for detection of alcohol relapse following liver transplantation for alcoholic cirrhosis

2000 ◽  
Vol 6 (3) ◽  
pp. C45-C45
Author(s):  
G BERLAKOVICH ◽  
T WINDHAGER ◽  
E FREUNDORFER ◽  
O LESCH ◽  
R STEININGER ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Alcoholic Cirrhosis ◽  
Alcohol Relapse

CARBOHYDRATE DEFICIENT TRANSFERRIN FOR DETECTION OF ALCOHOL RELAPSE AFTER ORTHOTOPIC LIVER TRANSPLANTATION FOR ALCOHOLIC CIRRHOSIS

1999 ◽  
Vol 67 (9) ◽  
pp. 1231-1235 ◽  
Author(s):  
Gabriela A. Berlakovich ◽  
Thomas Windhager ◽  
Edith Freundorfer ◽  
Otto M. Lesch ◽  
Rudolf Steininger ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Alcoholic Cirrhosis ◽  
Alcohol Relapse ◽  
Carbohydrate Deficient Transferrin

scholarly journals Predictors of Relapse to Significant Alcohol Drinking after Liver Transplantation

2010 ◽  
Vol 24 (4) ◽  
pp. 245-250 ◽  
Author(s):  
Zamil Karim ◽  
Pongphob Intaraprasong ◽  
Charles H Scudamore ◽  
Siegfried R Erb ◽  
John G Soos ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Logistic Regression ◽  
Liver Disease ◽  
Alcohol Consumption ◽  
Standard Error ◽  
Multivariate Logistic Regression ◽  
Harmful Drinking ◽  
Alcohol Relapse ◽  
Female Sex ◽  
Harmful Alcohol

BACKGROUND: End-stage alcoholic liver disease is common, with many of these patients referred for liver transplantation (LT). Alcohol relapse after LT can have detrimental outcomes such as graft loss and can contribute to a negative public perception of LT.OBJECTIVE: To identify factors that predict the recurrence of harmful alcohol consumption after LT.METHODS: A total of 80 patients who underwent LT for alcoholic cirrhosis or had significant alcohol consumption in association with another primary liver disease, from July 1992 to June 2006 in British Columbia, were retrospectively evaluated by chart review. Several demographic-, psychosocial- and addiction-related variables were studied. Univariate and multivariate logistic regression analyses were used to test possible associations among the variables studied and a return to harmful drinking after LT.RESULTS: The relapse rate of harmful alcohol consumption post-liver transplant was 10%, with two patient deaths occurring directly as a result of alcohol relapse. Univariate analysis revealed relapse was significantly associated with pretransplant abstinence of less than six months (P=0.003), presence of psychiatric comorbidities (P=0.016), female sex (P=0.019) and increased personal stressors (P=0.044), while age at transplant of younger than 50 years approached significance (P=0.054). Multivariate logistic regression analysis revealed the following independent factors for relapse: pretransplant abstinence of less than six months (OR 77.07; standard error 1.743; P=0.013) and female sex (OR 18.80; standard error 1.451; P=0.043).CONCLUSION: The findings of the present study strongly support a required minimum of six months of abstinence before LT because duration of abstinence was found to be the strongest predictor of recidivism. Female sex, younger age at transplant and psychiatric comorbidities were also associated with relapse to harmful drinking.

P900 LIVER TRANSPLANTATION FOR ALCOHOLIC CIRRHOSIS WITH RESPECT TO ALCOHOL RELAPSE AND LONG-TERM OUTCOME

2014 ◽  
Vol 60 (1) ◽  
pp. S374-S375
Author(s):  
G.A. Berlakovich ◽  
D. Kollmann ◽  
S. Rasoul-Rockenschaub ◽  
E. Freundorfer ◽  
G. Gyoeri ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Alcoholic Cirrhosis ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Alcohol Relapse
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