scholarly journals Comment on “Estimating serum‐ionized magnesium concentration in hemodialysis patients”

2021 ◽  
Author(s):  
Dennis G. Begos ◽  
Anne Deutsch
Keyword(s):  
Hemodialysis Patients ◽  
Magnesium Concentration ◽  
Ionized Magnesium

scholarly journals Estimating serum‐ionized magnesium concentration in hemodialysis patients

2021 ◽  
Author(s):  
Christopher Holzmann‐Littig ◽  
Claudius Kuechle ◽  
Andreas Bietenbeck ◽  
Wendy McCallum ◽  
Uwe Heemann ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Magnesium Concentration ◽  
Ionized Magnesium

scholarly journals Intracellular and extracellular blood magnesium fractions in hemodialysis patients; is the ionized fraction a measure of magnesium excess?

1998 ◽  
Vol 44 (3) ◽  
pp. 639-648 ◽  
Author(s):  
Henk J Huijgen ◽  
Renata Sanders ◽  
Rudolf W van Olden ◽  
Marjolein G Klous ◽  
Faryal R Gaffar ◽  
...  
Keyword(s):  
Blood Cells ◽  
Serum Magnesium ◽  
Hemodialysis Patients ◽  
Biologically Active ◽  
Magnesium Concentration ◽  
Total Serum ◽  
Ionized Magnesium ◽  
Magnesium Homeostasis ◽  
Mononuclear Blood Cells ◽  
Total Magnesium

Abstract To establish the best measure for determining magnesium overload, we measured ionized and total magnesium in serum and mononuclear blood cells and total magnesium in erythrocytes in blood of 23 hemodialysis patients, known for their disturbed magnesium homeostasis. When comparing the mean magnesium values obtained in the patient population with those of a control population, all of these magnesium markers, including the biologically active fractions, were significantly (P <0.05) increased. Because serum total magnesium was not increased in all dialysis patients studied, the population was divided into two groups, according to total serum magnesium >1.0 mmol/L or less than that. Results in these two populations showed that ionized serum magnesium and ionized magnesium in mononuclear blood cells might give a better indication about the magnesium status of the tested patients than the currently used total serum magnesium data. However, neither of the two markers, especially ionized serum magnesium, was able to discriminate fully between normal magnesium homeostasis and magnesium excess. We therefore conclude that the two ionized magnesium markers offer minimal advantage for this discrimination, and that the total magnesium concentration in serum remains the measurement of choice.

scholarly journals Determination of ionized magnesium in platelets and correlation with selected variables

1996 ◽  
Vol 42 (5) ◽  
pp. 744-748 ◽  
Author(s):  
J E Niemela ◽  
B M Snader ◽  
R J Elin
Keyword(s):  
Total Cholesterol ◽  
Inverse Correlation ◽  
Reference Interval ◽  
Cholesterol Concentration ◽  
Magnesium Concentration ◽  
Serum Electrolytes ◽  
Ionized Magnesium ◽  
And Gender ◽  
Dissociation Constant Kd

Abstract We describe a method for determining the intracellular ionized magnesium concentration ([Mg2+]i) in platelets by using the fluorescent probe FURAPTRA. We determined the dissociation constant (KD) of FURAPTRA for Mg2+ (2.26 +/- 0.29 mmol/L), within-day assay variability (CV = 6.8%), among-day intraindividual variability (CV = 11.0%), variability after a 4-h delay in processing the blood specimen (t = 1.2, P >0.2; F = 6.2, P <0.02), and the reference interval (0.23-0.59 mmol/L) for this assay. We also evaluated the correlation between platelet [Mg2+]i and concentrations of selected serum electrolytes, proteins, and total cholesterol; age; body mass index; and gender. Only the inverse correlation between platelet [Mg2+]i and serum total cholesterol concentration in men was significant (r=-0.66, P <0.005).

scholarly journals Circulating Ionized Magnesium as a Measure of Supplement Bioavailability: Results from a Pilot Study for Randomized Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1245 ◽  
Author(s):  
Jiada Zhan ◽  
Taylor C. Wallace ◽  
Sarah J. Butts ◽  
Sisi Cao ◽  
Velarie Ansu ◽  
...  
Keyword(s):  
Pilot Study ◽  
Whole Blood ◽  
Area Under The Curve ◽  
Oral Intake ◽  
Magnesium Content ◽  
Magnesium Concentration ◽  
Rank Test ◽  
Ionized Magnesium ◽  
Signed Rank Test ◽  
Total Magnesium

Oral supplementation may improve the dietary intake of magnesium, which has been identified as a shortfall nutrient. We conducted a pilot study to evaluate appropriate methods for assessing responses to the ingestion of oral magnesium supplements, including ionized magnesium in whole blood (iMg2+) concentration, serum total magnesium concentration, and total urinary magnesium content. In a single-blinded crossover study, 17 healthy adults were randomly assigned to consume 300 mg of magnesium from MgCl2 (ReMag®, a picosized magnesium formulation) or placebo, while having a low-magnesium breakfast. Blood and urine samples were obtained for the measurement of iMg2+, serum total magnesium, and total urine magnesium, during 24 h following the magnesium supplement or placebo dosing. Bioavailability was assessed using area-under-the-curve (AUC) as well as maximum (Cmax) and time-to-maximum (Tmax) concentration. Depending on normality, data were expressed as the mean ± standard deviation or median (range), and differences between responses to MgCl2 or placebo were measured using the paired t-test or Wilcoxon signed-rank test. Following MgCl2 administration versus placebo administration, we observed significantly greater increases in iMg2+ concentrations (AUC = 1.51 ± 0.96 vs. 0.84 ± 0.82 mg/dL•24h; Cmax = 1.38 ± 0.13 vs. 1.32 ± 0.07 mg/dL, respectively; both p < 0.05) but not in serum total magnesium (AUC = 27.00 [0, 172.93] vs. 14.55 [0, 91.18] mg/dL•24h; Cmax = 2.38 [1.97, 4.01] vs. 2.24 [1.98, 4.31] mg/dL) or in urinary magnesium (AUC = 201.74 ± 161.63 vs. 139.30 ± 92.84 mg•24h; Cmax = 26.12 [12.91, 88.63] vs. 24.38 [13.51, 81.51] mg/dL; p > 0.05). Whole blood iMg2+ may be a more sensitive measure of acute oral intake of magnesium compared to serum and urinary magnesium and may be preferred for assessing supplement bioavailability.

Cytosolic Ionized Magnesium Concentration in End-Stage Renal Disease

ASAIO Journal ◽  
1993 ◽  
Vol 39 (3) ◽  
pp. M614-M617 ◽  
Author(s):  
Charles J. Kaupke ◽  
Xin J. Zhou ◽  
N. D. Vaziri
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Magnesium Concentration ◽  
Ionized Magnesium ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Evaluation of Plasma-Ionized Magnesium Concentration in 122 Dogs with Diabetes Mellitus: A Retrospective Study

2004 ◽  
Vol 18 (5) ◽  
pp. 612-617 ◽  
Author(s):  
Suzanne C. Fincham ◽  
Kenneth J. Drobatz ◽  
Tracey N. Gillespie ◽  
Rebecka S. Hess
Keyword(s):  
Diabetes Mellitus ◽  
Retrospective Study ◽  
Magnesium Concentration ◽  
Ionized Magnesium

31P nuclear magnetic resonance and zero-point titration compared for measuring free magnesium concentration in erythrocytes

1991 ◽  
Vol 37 (12) ◽  
pp. 2076-2080 ◽  
Author(s):  
W B Geven ◽  
G M Vogels-Mentink ◽  
J L Willems ◽  
C H v Os ◽  
C W Hilbers ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
31P Nmr ◽  
Zero Point ◽  
Magnesium Concentration ◽  
Cell Water ◽  
Ionized Magnesium ◽  
31P Nuclear Magnetic Resonance ◽  
L Cell ◽  
Magnesium Loss

Abstract Intracellular ionized magnesium concentrations ([Mg2+]i) were measured in erythrocytes by 31P nuclear magnetic resonance (NMR) and zero-point titration in 14 controls and seven patients with renal magnesium loss. The mean intracellular ionized magnesium concentration in controls measured by 31P NMR was 0.20 (SD 0.03) mmol/L cell water, compared with 0.55 (SD 0.12) mmol/L cell water by zero-point titration. Total erythrocyte magnesium content measured with the lysate method was 0.63 mmol/L cell water higher than estimated by 31P NMR, probably because not all magnesium complexes are fully visible to the NMR technique. We found a positive correlation between plasma ultrafiltrable magnesium and [Mg2+]i irrespective of the [Mg2+]i assay used. [Mg2+]i measured with 31P NMR correlated modestly but significantly with [Mg2+]i determined by zero-point titration (r = 0.58, P less than 0.02). Washing erythrocytes before the zero-point titration decreased the ATP content and the cell water fraction, which led to overestimation of [Mg2+]i by zero-point titration. Although absolute values for [Mg2+]i differ with the assay used, both methods determined significantly lower values for [Mg2+]i in patients with isolated renal magnesium loss.

scholarly journals Plasma-Ionized Magnesium Concentration in a Child with Magnesium-Losing Tubulopathy

Nephron ◽  
1995 ◽  
Vol 71 (2) ◽  
pp. 238-239 ◽  
Author(s):  
Anita C. Truttmann ◽  
Regula Laux-End ◽  
John A.S. McGuigan ◽  
Mario G. Bianchetti
Keyword(s):  
Magnesium Concentration ◽  
Ionized Magnesium
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