Roles of Edc3 in the oxidative stress response andCaMCA1-encoded metacaspase expression inCandida albicans

FEBS Journal ◽  
2014 ◽  
Vol 281 (21) ◽  
pp. 4841-4851 ◽  
Author(s):  
Jong-Hwan Jung ◽  
Jinmi Kim
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Oxidative Stress Response ◽  
Incandida Albicans

Proteomic analysis of the oxidative stress response inCandida albicans

PROTEOMICS ◽  
2007 ◽  
Vol 7 (5) ◽  
pp. 686-697 ◽  
Author(s):  
Harald Kusch ◽  
Susanne Engelmann ◽  
Dirk Albrecht ◽  
Joachim Morschhäuser ◽  
Michael Hecker
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Proteomic Analysis ◽  
Oxidative Stress Response ◽  
Incandida Albicans

Function of glutaredoxin 3 (Grx3) in oxidative stress response caused by iron homeostasis disorder inCandida albicans

2017 ◽  
Vol 12 (15) ◽  
pp. 1397-1412 ◽  
Author(s):  
Dan Zhang ◽  
Yijie Dong ◽  
Qilin Yu ◽  
Zhang Kai ◽  
Meng Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Iron Homeostasis ◽  
Oxidative Stress Response ◽  
Incandida Albicans

The moonlighting protein Tsa1p is implicated in oxidative stress response and in cell wall biogenesis inCandida albicans

2005 ◽  
Vol 57 (5) ◽  
pp. 1318-1341 ◽  
Author(s):  
Constantin Urban ◽  
Xin Xiong ◽  
Kai Sohn ◽  
Klaus Schröppel ◽  
Herwig Brunner ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Wall ◽  
Stress Response ◽  
Oxidative Stress Response ◽  
Cell Wall Biogenesis ◽  
Moonlighting Protein ◽  
Incandida Albicans

scholarly journals Environmental Conditions Modulate the Transcriptomic Response of Both Caulobacter crescentus Morphotypes to Cu Stress

2021 ◽  
Vol 9 (6) ◽  
pp. 1116
Author(s):  
Laurens Maertens ◽  
Pauline Cherry ◽  
Françoise Tilquin ◽  
Rob Van Houdt ◽  
Jean-Yves Matroule
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Stress Responses ◽  
Caulobacter Crescentus ◽  
Oxidative Stress Response ◽  
Transport Systems ◽  
Transcriptomic Response ◽  
Swarmer Cell ◽  
Cu Stress ◽  
Cellular Environment

Bacteria encounter elevated copper (Cu) concentrations in multiple environments, varying from mining wastes to antimicrobial applications of copper. As the role of the environment in the bacterial response to Cu ion exposure remains elusive, we used a tagRNA-seq approach to elucidate the disparate responses of two morphotypes of Caulobacter crescentus NA1000 to moderate Cu stress in a complex rich (PYE) medium and a defined poor (M2G) medium. The transcriptome was more responsive in M2G, where we observed an extensive oxidative stress response and reconfiguration of the proteome, as well as the induction of metal resistance clusters. In PYE, little evidence was found for an oxidative stress response, but several transport systems were differentially expressed, and an increased need for histidine was apparent. These results show that the Cu stress response is strongly dependent on the cellular environment. In addition, induction of the extracytoplasmic function sigma factor SigF and its regulon was shared by the Cu stress responses in both media, and its central role was confirmed by the phenotypic screening of a sigF::Tn5 mutant. In both media, stalked cells were more responsive to Cu stress than swarmer cells, and a stronger basal expression of several cell protection systems was noted, indicating that the swarmer cell is inherently more Cu resistant. Our approach also allowed for detecting several new transcription start sites, putatively indicating small regulatory RNAs, and additional levels of Cu-responsive regulation.

scholarly journals Meta-Analysis of Oxidative Transcriptomes in Insects

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 345
Author(s):  
Hidemasa Bono
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Meta Analysis ◽  
Adherens Junction ◽  
Enrichment Analysis ◽  
Oxidative Stress Response ◽  
Insect Species ◽  
Rna Seq ◽  
Manual Curation ◽  
Analysis Workflow

Data accumulation in public databases has resulted in extensive use of meta-analysis, a statistical analysis that combines the results of multiple studies. Oxidative stress occurs when there is an imbalance between free radical activity and antioxidant activity, which can be studied in insects by transcriptome analysis. This study aimed to apply a meta-analysis approach to evaluate insect oxidative transcriptomes using publicly available data. We collected oxidative stress response-related RNA sequencing (RNA-seq) data for a wide variety of insect species, mainly from public gene expression databases, by manual curation. Only RNA-seq data of Drosophila melanogaster were found and were systematically analyzed using a newly developed RNA-seq analysis workflow for species without a reference genome sequence. The results were evaluated by two metric methods to construct a reference dataset for oxidative stress response studies. Many genes were found to be downregulated under oxidative stress and related to organ system process (GO:0003008) and adherens junction organization (GO:0034332) by gene enrichment analysis. A cross-species analysis was also performed. RNA-seq data of Caenorhabditis elegans were curated, since no RNA-seq data of insect species are currently available in public databases. This method, including the workflow developed, represents a powerful tool for deciphering conserved networks in oxidative stress response.

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