scholarly journals The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation

2015 ◽  
Vol 24 (5) ◽  
pp. 386-388 ◽  
Author(s):  
Bo Young Chung ◽  
Su Yeon Kim ◽  
Joon Min Jung ◽  
Chong Hyun Won ◽  
Jee Ho Choi ◽  
...  
Keyword(s):  
Antimycotic Agent

Miconazole, a Broad-Spectrum Antimycotic Agent with Antibacterial Activity

Chemotherapy ◽  
1972 ◽  
Vol 17 (6) ◽  
pp. 392-404 ◽  
Author(s):  
J.M. Van Cutsem ◽  
D. Thienpont
Keyword(s):  
Antibacterial Activity ◽  
Broad Spectrum ◽  
Antimycotic Agent

Effects of ketoconazole on the iodide uptake by FRTL-5 cells

1992 ◽  
Vol 127 (5) ◽  
pp. 449-453 ◽  
Author(s):  
Sergio L Kohan ◽  
Carlota E Guillén ◽  
Esther M Pardes ◽  
Marcelo Junco ◽  
Roberto J Soto ◽  
...  
Keyword(s):  
Culture Medium ◽  
Endocrine System ◽  
Inhibitory Effect ◽  
Thyroid Cell ◽  
Iodide Uptake ◽  
Uptake Inhibition ◽  
Dual Action ◽  
Antimycotic Agent ◽  
Rat Thyroid ◽  
Dose Dependent

Ketoconazole is an imidazole derivative used as an antimycotic agent with reported effects on the endocrine system, but very little is known about its possible actions on thyroid function. Our purpose was to study the influence of this substance on the basal and TSH-stimulated iodide uptake in the rat thyroid cell strain FRTL-5. Ketoconazole (1–50 μmol/l) was shown to slightly increase the basal iodide uptake but, at higher concentrations (75–100 μmol/l), it sharply decreased iodide uptake below the basal levels. When the cells were cultured under bTSH stimulation (30 UI/l), the inhibitory effect of ketoconazole was exerted at concentrations as low as 25 μmol/l. This inhibition was observed even if it was added to the culture medium immediately before the Na125I addition. Forskolin, a stimulator of adenylate cyclase activity, was unable to prevent the iodide uptake inhibition. Low doses of ketoconazole increased cAMP concentrations. In the presence of TSH this effect was more evident in an inverse dose-dependent way. Because of its dual action, it can be assumed that ketoconazole could influence the iodide uptake in the FRTL-5 cells through more than one mechanism.

Current Treatment Options for Vulvovaginal Candidiasis

2005 ◽  
Vol 1 (2) ◽  
pp. 253-261 ◽  
Author(s):  
Jack Sobel
Keyword(s):  
Antifungal Agents ◽  
Topical Therapy ◽  
Treatment Options ◽  
Correct Diagnosis ◽  
Management Strategies ◽  
Current Treatment ◽  
Vulvovaginal Candidiasis ◽  
Short Term ◽  
Appropriate Therapy ◽  
Antimycotic Agent

For practitioners, selecting successful therapy for vulvovaginal candidiasis is anything but trivial. The dominant problem; however, lies not with selecting the correct antimycotic agent, but with making the correct diagnosis and not treating non-yeast infections and noninfections as yeast-induced. Moreover, not all cases of vulvovaginal candidiasis are equal and practitioners owe patients the obligation of selecting appropriate therapy based upon the specific type and severity of vulvovaginal candidiasis. Uncomplicated candidiasis is readily treated with short-term oral or topical therapy, whereas complicated candidiasis needs additional strategies using the plethora of therapies available. Problematic refractory cases still abound and the pipeline for new, more potent antifungal agents is largely empty. Management strategies for complicated Candida vaginitis are discussed.

scholarly journals Effect of antimycotic agents on the activity of aspartyl proteinases secreted by Candida albicans

2003 ◽  
Vol 52 (3) ◽  
pp. 247-249 ◽  
Author(s):  
Martin Schaller ◽  
Nikola Krnjaic ◽  
Markus Niewerth ◽  
Gerald Hamm ◽  
Bernhard Hube ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Amphotericin B ◽  
Proteinase Inhibitors ◽  
Inhibitory Effect ◽  
Antifungal Drugs ◽  
Immunodeficiency Virus ◽  
Antimycotic Agent ◽  
Pepstatin A ◽  
Aspartyl Proteinases

The inhibitory effect of human immunodeficiency virus (HIV) proteinase inhibitors amprenavir and saquinavir and antifungal agents terbinafine, ketoconazole, amphotericin B and ciclopiroxolamine on aspartyl proteinases (Saps) secreted by Candida albicans was tested in an in vitro spectophotometric assay. As expected, both HIV proteinase inhibitors showed a significant inhibitory effect on Sap activity, which was comparable to that of the classical aspartyl proteinase inhibitor pepstatin A (P < 0.001). Antifungal drugs such as ketoconazole, terbinafine and amphotericin B had no, or only minor, inhibitory effects on proteolytic activity. In contrast, a significant reduction in Sap activity could be demonstrated during treatment with the antifungal agent ciclopiroxolamine (P < 0.001). These results point to a multiple effect of this antimycotic agent and might explain the reduced adherence of C. albicans to human epithelial cells at subinhibitory doses.

scholarly journals Intravitreal Therapy of Endogenous Endophthalmitis due to Urosepsis – A Case Report

2019 ◽  
Vol 75 (5) ◽  
pp. 277-282
Author(s):  
Jela Valášková ◽  
Jana Sitárová ◽  
Vladimír Krásnik
Keyword(s):  
Internal Medicine ◽  
Staphylococcus Aureus ◽  
Visual Acuity ◽  
Case Report ◽  
Antibiotic Treatment ◽  
Hand Movement ◽  
Endogenous Endophthalmitis ◽  
Intravitreal Therapy ◽  
Microbiological Examination ◽  
Antimycotic Agent

This case report describes a case of endogenous endophthalmitis in a 58 year old man upon a background of urosepsis and bronchitis. The patient was hospitalised at a department of internal medicine in another hospital. The day after admittance he was sent to our clinic for a consultation examination due to worsening of vision and pain in the left eye. The condition was diagnosed as endogenous endophthalmitis. Visual acuity at the first examination was hand movement in front of the eye. Intravitreal therapy was commenced with a combination of two antibiotics (ceftazidime 2 mg/ 0.1 ml and vancomycin 1 mg/0.1 ml) and an antimycotic agent (amphotericin B 10 μg/0.1 ml). Over the course of two weeks the patient received this antibiotic treatment intravitreally 3x in total. During the first application of antibiotics, material was sampled from the anterior chamber of the eye for a microbiological examination – the result was negative. The blood culture tested positive for staphylococcus aureus. Intravenous application of antibiotics (gentamicin 240 mg i.v. every 24 hours and amoxicillin with clavulanic acid 1.2 g i.v. every 8 hours) was set for two weeks, and then antibiotic treatment continued (ciprofloxacin 500 mg every 12 hours) and antimycotic therapy (itraconazole 100 mg every 12 hours) orally for 2 months. Four weeks after the beginning of therapy, visual acuity in the left eye was 20/100 and after two months 20/40. The study emphasises the advantage of multi-disciplinary co-operation.

Production of a New Antimycotic Agent by Plant Cell Culture

1998 ◽  
pp. 83-95 ◽  
Author(s):  
Ma. Luisa Villarreal ◽  
Carlos Arias ◽  
Alfredo Feria ◽  
Octavio T. Ramírez ◽  
Rodolfo Quintero
Keyword(s):  
Cell Culture ◽  
Plant Cell ◽  
Plant Cell Culture ◽  
Antimycotic Agent
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