Pleomorphic sarcoma with giant cells infiltrating the infraorbital canal in an aged Thoroughbred mare

2019 ◽  
Vol 32 (12) ◽  
Author(s):  
G. L. Elane ◽  
E. M. Corbin ◽  
L. Reig ◽  
J. A. Brown
Keyword(s):  
Giant Cells ◽  
Pleomorphic Sarcoma ◽  
Infraorbital Canal

A case of undifferentiated pleomorphic sarcoma with giant cells arising from the chest wall with pleural effusion

2014 ◽  
Vol 53 (1) ◽  
pp. 35-40
Author(s):  
Eiji SADASHIMA ◽  
Mayuko KAWAHARA ◽  
Junko KINOSHITA ◽  
Kanako YAMAZAKI ◽  
Natsu SADASHIMA ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Chest Wall ◽  
Giant Cells ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma

Feline giant-cell pleomorphic sarcoma: cytologic, histologic and immunohistochemical characterization

2020 ◽  
pp. 1098612X2097266
Author(s):  
Bianca S de Cecco ◽  
Fernando F Argenta ◽  
Ronaldo M Bianchi ◽  
Cíntia De Lorenzo ◽  
Júlia G Wronski ◽  
...  
Keyword(s):  
Giant Cell ◽  
Calcium Binding ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Pleomorphic Sarcoma ◽  
Spindle Cells ◽  
S 100 ◽  
Veterinary Pathology ◽  
Hematoxylin And Eosin ◽  
Giant Cell Type

Objectives This study aimed to characterize the cytologic, pathologic and immunohistochemical (IHC) aspects of feline giant-cell sarcoma. Methods Biopsy and necropsy reports from the Department of Veterinary Pathology were retrieved, and 13 cases of pleomorphic sarcoma (PS) were selected according to the established epidemiologic, pathologic and IHC criteria. All samples were fixed in 10% formalin, routinely processed for histology, and stained with hematoxylin and eosin. Samples also underwent IHC testing for vimentin, ionized calcium-binding adaptor molecule 1 (Iba-1), desmin, actin and S-100. Results The mean age of the affected cats was 9.5 years, and females were over-represented. Most neoplasms were observed in the flank, lateral thorax, limbs and interscapular region, and were >2 cm in diameter. Cytology analysis revealed highly cellular preparations with three distinct populations (spindle cells, small round cells and multinucleated giant cells) in a dense eosinophilic stroma. Histologically, PS was composed of a combination of these three populations. IHC labeling for vimentin and Iba-1 was strongly positive for spindle cells and multinucleated giant cells, respectively. Desmin/actin showed variable labeling among the samples. S-100 was negative in all samples. Conclusions and relevance PS is a neoplasm of mesenchymal origin, also known as malignant fibrous histiocytoma. The predominant subtype in this study that affected the cats was the giant-cell type, characterized by the presence of multinucleated giant cells among spindle-shaped cells. These findings are similar to those described in human patients; thus, a comparison between the neoplasms seen in these species might be useful, and the knowledge of biologic behavior and overall treatment approach for humans could be extrapolated to cats.

scholarly journals Sarcomatoid Carcinoma of the Prostate: Ductal Adenocarcinoma and Stromal Sarcoma-Like Appearance: A Rare Association

2011 ◽  
Vol 2011 ◽  
pp. 1-6
Author(s):  
David Parada ◽  
Karla B. Peña ◽  
Francesc Riu
Keyword(s):  
Prostate Gland ◽  
Sarcomatoid Carcinoma ◽  
Progesterone Receptors ◽  
Giant Cells ◽  
Clinical Findings ◽  
Ductal Adenocarcinoma ◽  
Rare Tumour ◽  
Pleomorphic Sarcoma ◽  
Stromal Sarcoma ◽  
Biphasic Tumour

Sarcomatoid carcinoma (SC) of prostate gland is a rare biphasic tumour. In about half of cases, initial diagnosis is acinar adenocarcinoma, followed by nonsurgical therapy, with a subsequent diagnosis of SC. The survival rate is lower. We report a case of an 59-years-old man with unusual histopathologic finding of prostate sarcomatoid carcinoma, showing characteristics of ductal prostatic adenocarcinoma and prostatic stromal sarcoma-like appearance. Ductal adenocarcinoma was characterized by tall columnar cells with abundant amphophilic to eosinophil cytoplasm. Pleomorphic sarcoma was characterized to have overall glandular growth pattern, simulating a malignant phyllodes tumour. Estrogen and progesterone receptors showed nuclear immunostaining in mesenchymal multinucleated giant cells. In conclusion, SC of the prostate is an exceedingly rare tumour. Retrospective analyses render prostate SC as one of the most aggressive prostate malignancies. The prognosis is dismal regardless of other histologic or clinical findings.

scholarly journals Primary diaphragmatic undifferentiated pleomorphic sarcoma in a cat

2021 ◽  
Vol 7 (1) ◽  
pp. 205511692110189
Author(s):  
Irene Bonazzi ◽  
Simona Morabito ◽  
Barbara Brunetti ◽  
Stefano Nicoli ◽  
Paola Valenti
Keyword(s):  
Pleural Effusion ◽  
Soft Tissue ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Whole Body ◽  
Left Hemithorax ◽  
Tissue Mass ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma ◽  
Contrast Enhanced Ct

Case summary A 5-year-old neutered female domestic shorthair cat was referred for acute onset of dyspnoea. Thoracic radiographs performed by the referring veterinarian revealed the presence of pleural effusion. Upon presentation, the cat was dyspnoeic, and cardiopulmonary auscultation revealed muffled heart sounds and bilaterally increased bronchovesicular sounds. Radiographic study of the thorax revealed bilateral pleural effusion and a soft tissue opacity in the dorsocaudal region of the left hemithorax. A whole-body contrast-enhanced CT scan identified a soft tissue mass arising from the left diaphragmatic crus. Transthoracic ultrasound-guided fine-needle aspiration (FNA) of the mass was performed and the result was consistent with a malignant mesenchymal neoplasia, showing giant cells. Cytoreductive surgery was performed and the histopathology diagnosis of undifferentiated pleomorphic sarcoma was made. Adjuvant chemotherapy was then offered. Ten days after surgery pleural effusion recurred. Thoracic echography revealed the presence of a diaphragmatic thickening in the area of surgical resection. FNA of the thickening was consistent with mesenchymal neoplasia. Even when chemotherapy and supportive treatment with pain relief was instituted, the clinical condition of the cat worsened within a few days and it was euthanased 1 month after surgery. Relevance and novel information Primary diaphragmatic tumours (PDTs) have been rarely reported in human and in veterinary medicine, where only three cases have been described in the dog. To our knowledge, this is the first report to describe a PDT, specifically an undifferentiated pleomorphic sarcoma, in a cat.

scholarly journals Undifferentiated pleomorphic sarcoma with osteoclast-like giant cells of the female breast

2013 ◽  
Vol 11 (1) ◽  
Author(s):  
Giancarlo Balbi ◽  
Luca Di Martino ◽  
GianPaolo Pitruzzella ◽  
Diego Pitruzzella ◽  
Flavio Grauso ◽  
...  
Keyword(s):  
Giant Cells ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma ◽  
Female Breast
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