A case of undifferentiated pleomorphic sarcoma with giant cells arising from the chest wall with pleural effusion

2014 ◽  
Vol 53 (1) ◽  
pp. 35-40
Author(s):  
Eiji SADASHIMA ◽  
Mayuko KAWAHARA ◽  
Junko KINOSHITA ◽  
Kanako YAMAZAKI ◽  
Natsu SADASHIMA ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Chest Wall ◽  
Giant Cells ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma

scholarly journals Primary diaphragmatic undifferentiated pleomorphic sarcoma in a cat

2021 ◽  
Vol 7 (1) ◽  
pp. 205511692110189
Author(s):  
Irene Bonazzi ◽  
Simona Morabito ◽  
Barbara Brunetti ◽  
Stefano Nicoli ◽  
Paola Valenti
Keyword(s):  
Pleural Effusion ◽  
Soft Tissue ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Whole Body ◽  
Left Hemithorax ◽  
Tissue Mass ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma ◽  
Contrast Enhanced Ct

Case summary A 5-year-old neutered female domestic shorthair cat was referred for acute onset of dyspnoea. Thoracic radiographs performed by the referring veterinarian revealed the presence of pleural effusion. Upon presentation, the cat was dyspnoeic, and cardiopulmonary auscultation revealed muffled heart sounds and bilaterally increased bronchovesicular sounds. Radiographic study of the thorax revealed bilateral pleural effusion and a soft tissue opacity in the dorsocaudal region of the left hemithorax. A whole-body contrast-enhanced CT scan identified a soft tissue mass arising from the left diaphragmatic crus. Transthoracic ultrasound-guided fine-needle aspiration (FNA) of the mass was performed and the result was consistent with a malignant mesenchymal neoplasia, showing giant cells. Cytoreductive surgery was performed and the histopathology diagnosis of undifferentiated pleomorphic sarcoma was made. Adjuvant chemotherapy was then offered. Ten days after surgery pleural effusion recurred. Thoracic echography revealed the presence of a diaphragmatic thickening in the area of surgical resection. FNA of the thickening was consistent with mesenchymal neoplasia. Even when chemotherapy and supportive treatment with pain relief was instituted, the clinical condition of the cat worsened within a few days and it was euthanased 1 month after surgery. Relevance and novel information Primary diaphragmatic tumours (PDTs) have been rarely reported in human and in veterinary medicine, where only three cases have been described in the dog. To our knowledge, this is the first report to describe a PDT, specifically an undifferentiated pleomorphic sarcoma, in a cat.

scholarly journals Undifferentiated pleomorphic sarcoma with osteoclast-like giant cells of the female breast

2013 ◽  
Vol 11 (1) ◽  
Author(s):  
Giancarlo Balbi ◽  
Luca Di Martino ◽  
GianPaolo Pitruzzella ◽  
Diego Pitruzzella ◽  
Flavio Grauso ◽  
...  
Keyword(s):  
Giant Cells ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma ◽  
Female Breast

scholarly journals Successful Multidisciplinary Treatment for Aggressive Primary Pulmonary Undifferentiated Pleomorphic Sarcoma

2020 ◽  
Vol 13 (1) ◽  
pp. 385-391 ◽  
Author(s):  
Mitsunori Higuchi ◽  
Hitoshi Yamada ◽  
Kakeru Machino ◽  
Ikuro Oshibe ◽  
Nobutoshi Soeta ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Multidisciplinary Treatment ◽  
Stage Iv ◽  
Resected Specimen ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma ◽  
18F Fluorodeoxyglucose ◽  
Positron Emission ◽  
Left Upper Lobectomy ◽  
Almost All

Undifferentiated pleomorphic sarcoma (UPS) was previously known as malignant fibrous histiocytoma (MFH). This sarcoma occurs preferentially in the extremities and retroperitoneal space; primary pulmonary UPS/MFH is rare. We report a 52-year-old woman referred to our hospital with dyspnea and severe cough. Chest computed tomography (CT) revealed a pulmonary mass in the left upper lobe and pleural effusion. Cytology of the effusion showed no malignancy; however, the tumor increased rapidly in size, and the patient’s respiratory symptoms worsened. The tumor occupied almost all of the left upper lobe and involved the adjacent pericardium. She underwent left upper lobectomy with pericardial resection and reconstruction. Postoperative pathology of the resected specimen showed undifferentiated pulmonary sarcoma, pT4N0M1a stage IV A, and genetic analyses revealed the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation. The patient’s dyspnea recurred 1 month postoperatively, and CT showed marked pleural effusion. An 18F-fluorodeoxyglucose positron emission tomography demonstrated abnormal diffuse accumulation of 18F-fluorodeoxyglucose in the left pleural cavity. We initiated five cycles of chemotherapy with doxorubicin and ifosfamide, and the patient has been well without recurrence for 24 months after multidisciplinary treatment with surgery followed by systemic combination chemotherapy. We successfully treated our patient with primary pulmonary UPS/MFH using a multidisciplinary approach, even though this sarcoma carries a poor prognosis and is insensitive to both chemotherapy and radiotherapy.

Undifferentiated pleomorphic sarcoma of the chest wall: a rare diagnosis

2021 ◽  
Vol 14 (10) ◽  
pp. e245366
Author(s):  
Swarnita Sahu ◽  
Shikha Halder ◽  
Sunila Jain ◽  
Rakesh Kumar Koul
Keyword(s):  
Chronic Disease ◽  
Chest Wall ◽  
Adjuvant Radiotherapy ◽  
Anterior Chest Wall ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma ◽  
History Of ◽  
Rare Diagnosis ◽  
Disease Free

A 31-year-old man with no predisposing factors and no history of chronic disease presented with a small painless lump over his anterior chest wall. On evaluation, it was found to be undifferentiated pleomorphic sarcoma. He underwent wide local excision of the tumour with clear margins, followed by adjuvant radiotherapy. At 6-month follow-up, the patient is clinically and radiologically disease free.

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