Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model

Epilepsia ◽  
2018 ◽  
Vol 59 (3) ◽  
pp. 724-735 ◽  
Author(s):  
Cameron S. Metcalf ◽  
Brian D. Klein ◽  
Misty D. Smith ◽  
Marc Ceusters ◽  
Hilde Lavreysen ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Subtype ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Metabotropic Glutamate

In vitro binding of a radio-labeled positive allosteric modulator for metabotropic glutamate receptor subtype 5

Synapse ◽  
2012 ◽  
Vol 67 (3) ◽  
pp. 135-144 ◽  
Author(s):  
John R. Zysk ◽  
Nathan Spear ◽  
William Fieles ◽  
Mark M. Stein ◽  
Linda S. Sygowski ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Subtype ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Metabotropic Glutamate ◽  
In Vitro Binding ◽  
Vitro Binding
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