scholarly journals Probing the Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations That Engender a “Molecular Switch” in PAM Pharmacology

2013 ◽  
Vol 83 (5) ◽  
pp. 991-1006 ◽  
Author(s):  
Karen J. Gregory ◽  
Elizabeth D. Nguyen ◽  
Sean D. Reiff ◽  
Emma F. Squire ◽  
Shaun R. Stauffer ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Point Mutations ◽  
Binding Pocket ◽  
Molecular Switch ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate

Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator

2011 ◽  
Vol 659 (2-3) ◽  
pp. 146-154 ◽  
Author(s):  
Nathan Spear ◽  
Reto A. Gadient ◽  
Deidre E. Wilkins ◽  
MyLinh Do ◽  
Jeffrey S. Smith ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate
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