Population Pharmacokinetic and Exposure-dizziness Modeling for a Metabotropic Glutamate Receptor Subtype 5 Negative Allosteric Modulator in Major Depressive Disorder Patients

Valérie Cosson; Franziska Schaedeli-Stark; Mona Arab-Alameddine; Clarisse Chavanne; Elena Guerini; Michael Derks; Navita L. Mallalieu

doi:10.1111/cts.12566

Population Pharmacokinetic and Exposure-dizziness Modeling for a Metabotropic Glutamate Receptor Subtype 5 Negative Allosteric Modulator in Major Depressive Disorder Patients

Clinical and Translational Science ◽

10.1111/cts.12566 ◽

2018 ◽

Vol 11 (5) ◽

pp. 523-531

Author(s):

Valérie Cosson ◽

Franziska Schaedeli-Stark ◽

Mona Arab-Alameddine ◽

Clarisse Chavanne ◽

Elena Guerini ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Population Pharmacokinetic ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Major Depressive ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5

Expert Opinion on Investigational Drugs ◽

10.1517/13543784.2015.1074175 ◽

2015 ◽

Vol 24 (9) ◽

pp. 1247-1260 ◽

Cited By ~ 25

Author(s):

Kjell Fuxe ◽

Dasiel O Borroto-Escuela

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Major Depressive ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5

Drug Metabolism and Disposition ◽

10.1124/dmd.112.046136 ◽

2012 ◽

Vol 40 (9) ◽

pp. 1834-1845 ◽

Cited By ~ 30

Author(s):

Ryan D. Morrison ◽

Anna L. Blobaum ◽

Frank W. Byers ◽

Tammy S. Santomango ◽

Thomas M. Bridges ◽

...

Keyword(s):

Xanthine Oxidase ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Aldehyde Oxidase ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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Positron Emission Tomography (PET) Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Based on a Negative Allosteric Modulator Radioligand

Neuromethods - Metabotropic Glutamate Receptor Technologies ◽

10.1007/978-1-0716-1107-4_2 ◽

2021 ◽

pp. 23-37

Author(s):

Xiaofei Zhang ◽

Zhiwei Xiao ◽

Katsushi Kumata ◽

Tomoteru Yamasaki ◽

Lee Josephson ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Pet Imaging ◽

Metabotropic Glutamate Receptor ◽

Emission Tomography ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Positron Emission ◽

Negative Allosteric Modulator

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Effects of a Metabotropic Glutamate Receptor Subtype 7 Negative Allosteric Modulator in the Periaqueductal Grey on Pain Responses and Rostral Ventromedial Medulla Cell Activity in Rat

Molecular Pain ◽

10.1186/1744-8069-9-44 ◽

2013 ◽

Vol 9 ◽

pp. 1744-8069-9-44 ◽

Cited By ~ 17

Author(s):

Enza Palazzo ◽

Ida Marabese ◽

Livio Luongo ◽

Serena Boccella ◽

Giulia Bellini ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Cell Activity ◽

Rostral Ventromedial Medulla ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Periaqueductal Grey ◽

Metabotropic Glutamate ◽

Ventromedial Medulla ◽

Negative Allosteric Modulator

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Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b01005 ◽

2015 ◽

Vol 58 (18) ◽

pp. 7485-7500 ◽

Cited By ~ 35

Author(s):

Julie L. Engers ◽

Alice L. Rodriguez ◽

Leah C. Konkol ◽

Ryan D. Morrison ◽

Analisa D. Thompson ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Anxiolytic Activity ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator ◽

Subtype 3

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Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00410 ◽

2017 ◽

Vol 60 (12) ◽

pp. 5072-5085 ◽

Cited By ~ 15

Author(s):

Andrew S. Felts ◽

Alice L. Rodriguez ◽

Anna L. Blobaum ◽

Ryan D. Morrison ◽

Brittney S. Bates ◽

...

Keyword(s):

Glutamate Receptor ◽

Clinical Evaluation ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study

Biological Psychiatry Cognitive Neuroscience and Neuroimaging ◽

10.1016/j.bpsc.2017.03.019 ◽

2017 ◽

Vol 2 (5) ◽

pp. 449-456 ◽

Cited By ~ 16

Author(s):

Chadi G. Abdallah ◽

Jonas Hannestad ◽

Graeme F. Mason ◽

Sophie E. Holmes ◽

Nicole DellaGioia ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Glutamate Receptor ◽

Multimodal Imaging ◽

Metabotropic Glutamate Receptor ◽

Imaging Study ◽

Major Depressive ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis

Molecular Pharmacology ◽

10.1124/mol.107.035170 ◽

2007 ◽

Vol 72 (2) ◽

pp. 477-484 ◽

Cited By ~ 116

Author(s):

Michael A. Benneyworth ◽

Zixiu Xiang ◽

Randy L. Smith ◽

Efrain E. Garcia ◽

P. Jeffrey Conn ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate ◽

Hallucinogenic Drug

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Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator

Psychopharmacology ◽

10.1007/s00213-012-2804-z ◽

2012 ◽

Vol 225 (1) ◽

pp. 151-159 ◽

Cited By ~ 23

Author(s):

Lucas R. Watterson ◽

Peter R. Kufahl ◽

Natali E. Nemirovsky ◽

Kaveish Sewalia ◽

Lauren E. Hood ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Seeking Behavior ◽

Negative Allosteric Modulator ◽

Food Seeking

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Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in Mice

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.106.102046 ◽

2006 ◽

Vol 318 (1) ◽

pp. 173-185 ◽

Cited By ~ 124

Author(s):

Ruggero Galici ◽

Carrie K. Jones ◽

Kamondanai Hemstapat ◽

Yi Nong ◽

Nicholas G. Echemendia ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Metabotropic Glutamate

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