scholarly journals SORL1rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals

2016 ◽  
Vol 24 (1) ◽  
pp. 187-194 ◽  
Author(s):  
H. Li ◽  
C. L. Lv ◽  
C. S. Yang ◽  
D. F. Wei ◽  
K. W. Chen ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Volume Reduction ◽  
Matter Volume ◽  
Age Related ◽  
Age Related Cognitive Decline

scholarly journals Gray matter declines with age and hearing loss, but is partially maintained in tinnitus

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Elouise A. Koops ◽  
Emile de Kleine ◽  
Pim van Dijk
Keyword(s):  
Hearing Loss ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Auditory Pathway ◽  
Brain Areas ◽  
Matter Volume ◽  
Age Related ◽  
Surface Thickness

AbstractThe impact of age-related hearing loss extends beyond the auditory pathway and impacts brain areas related to cognitive impairment and even dementia. The presence of tinnitus, a sensation of sound that frequently co-occurs with hearing loss, is additionally linked to cognitive decline. Interestingly, structural neuroimaging studies have reported that hearing loss may precede or modulate the onset of cognitive impairment. In this study, we aimed to disentangle the effects of age, hearing loss, and tinnitus on gray matter structure. In total, 39 participants with hearing loss and tinnitus, 21 with hearing loss but without tinnitus, and 39 controls were included in this voxel- and surface-based morphometry MRI study. Whole brain volume and surface thickness measures were compared between the groups. Age-related gray matter volume decline was observed in all groups. Several brain areas showed smaller gray matter volume and cortical surface thickness in hearing loss without tinnitus, relative to controls. This reduction was observed both within and outside of the auditory pathway. Interestingly, these reductions were not observed in participants with tinnitus, who had similar hearing loss and were of similar age. Since we have tools to improve hearing loss, hearing screening may aid in the battle against cognitive decline.

scholarly journals Protective Effect of Human Leukocyte Antigen (HLA) Allele DRB1*13:02 on Age-Related Brain Gray Matter Volume Reduction in Healthy Women

EBioMedicine ◽  
2018 ◽  
Vol 29 ◽  
pp. 31-37 ◽  
Author(s):  
Lisa M. James ◽  
Peka Christova ◽  
Scott M. Lewis ◽  
Brian E. Engdahl ◽  
Angeliki Georgopoulos ◽  
...  
Keyword(s):  
Protective Effect ◽  
Human Leukocyte Antigen ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Human Leukocyte ◽  
Volume Reduction ◽  
Leukocyte Antigen ◽  
Matter Volume ◽  
Age Related ◽  
Allele Drb1

Gray matter volume reduction reflects chronic pain in trigeminal neuralgia

2012 ◽  
Vol 43 (01) ◽  
Author(s):  
M Obermann ◽  
R Rodriguez-Raecke ◽  
S Nägel ◽  
D Holle ◽  
N Theysohn ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Trigeminal Neuralgia ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Volume Reduction ◽  
Matter Volume

scholarly journals A History of Psychosis in Bipolar Disorder is Associated With Gray Matter Volume Reduction

2016 ◽  
Vol 43 (1) ◽  
pp. 99-107 ◽  
Author(s):  
Carl Johan Ekman ◽  
Predrag Petrovic ◽  
Anette G. M. Johansson ◽  
Carl Sellgren ◽  
Martin Ingvar ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Volume Reduction ◽  
Matter Volume ◽  
History Of

scholarly journals Moderating Effect of Insulin Resistance on the Relationship between Gray Matter Volumes and Cognitive Function

2018 ◽  
Vol 7 (11) ◽  
pp. 413 ◽  
Author(s):  
Jiyeon Lee ◽  
Jihyeon Kim ◽  
Seong Shin ◽  
Soowon Park ◽  
Dong Yoon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Structural Changes ◽  
Gray Matter Volume ◽  
Volume Loss ◽  
Matter Volume

Background: It is controversial whether exposure to insulin resistance accelerates cognitive deterioration. The present study aimed to investigate the association between insulin resistance and gray matter volume loss to predict the cognitive decline. Methods: We recruited 160 participants (78 with Alzheimer’s disease and 82 without Alzheimer’s disease). Insulin resistance, regional gray matter volume, and cognitive function were assessed. A hierarchical moderated multiple regression (MMR) model was used to determine any associations among insulin resistance, structural changes in the brain, and cognitive decline. Results: The volumes of 7 regions in the gray matter were negatively related to insulin resistance in Alzheimer’s disease (p =0.032). Hierarchical MMR analysis indicated that insulin resistance did not directly affect the cognitive decline but moderated the cognitive decline through the decrease in gray matter volume in the key brain regions, i.e., inferior orbitofrontal gyrus (left), middle cingulate gyrus (right), hippocampus (right), and precuneus (right) (p < 0.05 in each case). Conclusion: Insulin resistance appears to exacerbate the cognitive decline associated with several gray matter volume loss.

scholarly journals Age-related changes in baroreflex sensitivity and cardiac autonomic tone in children mirrored by regional brain gray matter volume trajectories

2017 ◽  
Vol 83 (2) ◽  
pp. 498-505 ◽  
Author(s):  
Mark W DiFrancesco ◽  
Abu Shamsuzzaman ◽  
Keith B McConnell ◽  
Stacey L Ishman ◽  
Nanhua Zhang ◽  
...  
Keyword(s):  
Gray Matter ◽  
Baroreflex Sensitivity ◽  
Gray Matter Volume ◽  
Autonomic Tone ◽  
Matter Volume ◽  
Regional Brain ◽  
Age Related ◽  
Age Related Changes

Associations Between the Subjective Cognitive Decline-Questionnaire’s Scores, Gray Matter Volume, and Amyloid-β Levels

2019 ◽  
Vol 72 (4) ◽  
pp. 1287-1302
Author(s):  
Natalia Valech ◽  
Gonzalo Sánchez-Benavides ◽  
Adrià Tort-Merino ◽  
Nina Coll-Padrós ◽  
Jaume Olives ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Amyloid Β ◽  
Subjective Cognitive Decline ◽  
Matter Volume

The impulsivity behavior is correlated with prefrontal cortex gray matter volume reduction in heroin-dependent individuals

2013 ◽  
Vol 538 ◽  
pp. 43-48 ◽  
Author(s):  
Ying-wei Qiu ◽  
Gui-hua Jiang ◽  
Huan-huan Su ◽  
Xiao-fei Lv ◽  
Jun-zhang Tian ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Volume Reduction ◽  
Matter Volume
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