scholarly journals Age-related changes in baroreflex sensitivity and cardiac autonomic tone in children mirrored by regional brain gray matter volume trajectories

2017 ◽  
Vol 83 (2) ◽  
pp. 498-505 ◽  
Author(s):  
Mark W DiFrancesco ◽  
Abu Shamsuzzaman ◽  
Keith B McConnell ◽  
Stacey L Ishman ◽  
Nanhua Zhang ◽  
...  
Keyword(s):  
Gray Matter ◽  
Baroreflex Sensitivity ◽  
Gray Matter Volume ◽  
Autonomic Tone ◽  
Matter Volume ◽  
Regional Brain ◽  
Age Related ◽  
Age Related Changes

scholarly journals Normal age-related brain morphometric changes: nonuniformity across cortical thickness, surface area and gray matter volume?

2012 ◽  
Vol 33 (3) ◽  
pp. 617.e1-617.e9 ◽  
Author(s):  
Herve Lemaitre ◽  
Aaron L. Goldman ◽  
Fabio Sambataro ◽  
Beth A. Verchinski ◽  
Andreas Meyer-Lindenberg ◽  
...  
Keyword(s):  
Surface Area ◽  
Cortical Thickness ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Age Related

scholarly journals Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults

2019 ◽  
Vol 75 (8) ◽  
pp. 1558-1565 ◽  
Author(s):  
Cutter A Lindbergh ◽  
Kaitlin B Casaletto ◽  
Adam M Staffaroni ◽  
Fanny Elahi ◽  
Samantha M Walters ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Brain Health ◽  
Necrosis Factor Alpha ◽  
Matter Volume ◽  
Age Related ◽  
Tnf Α ◽  
Factor Alpha ◽  
State Examination ◽  
Necrosis Factor

Abstract Background Central nervous system levels of tumor necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine, regulate the neuroinflammatory response and may play a role in age-related neurodegenerative diseases. The longitudinal relation between peripheral levels of TNF-α and typical brain aging is understudied. We hypothesized that within-person increases in systemic TNF-α would track with poorer brain health outcomes in functionally normal adults. Methods Plasma-based TNF-α concentrations (pg/mL; fasting morning draws) and magnetic resonance imaging were acquired in 424 functionally intact adults (mean age = 71) followed annually for up to 8.4 years (mean follow-up = 2.2 years). Brain outcomes included total gray matter volume and white matter hyperintensities. Cognitive outcomes included composites of memory, executive functioning, and processing speed, as well as Mini-Mental State Examination total scores. Longitudinal mixed-effects models were used, controlling for age, sex, education, and total intracranial volume, as appropriate. Results TNF-α concentrations significantly increased over time (p < .001). Linear increases in within-person TNF-α were longitudinally associated with declines in gray matter volume (p < .001) and increases in white matter hyperintensities (p = .003). Exploratory analyses suggested that the relation between TNF-α and gray matter volume was curvilinear (TNF-α 2p = .002), such that initial increases in inflammation were associated with more precipitous atrophy. There was a negative linear relationship of within-person changes in TNF-α to Mini-Mental State Examination scores over time (p = .036) but not the cognitive composites (all ps >.05). Conclusion Systemic inflammation, as indexed by plasma TNF-α, holds potential as a biomarker for age-related declines in brain health.

scholarly journals Gray matter declines with age and hearing loss, but is partially maintained in tinnitus

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Elouise A. Koops ◽  
Emile de Kleine ◽  
Pim van Dijk
Keyword(s):  
Hearing Loss ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Auditory Pathway ◽  
Brain Areas ◽  
Matter Volume ◽  
Age Related ◽  
Surface Thickness

AbstractThe impact of age-related hearing loss extends beyond the auditory pathway and impacts brain areas related to cognitive impairment and even dementia. The presence of tinnitus, a sensation of sound that frequently co-occurs with hearing loss, is additionally linked to cognitive decline. Interestingly, structural neuroimaging studies have reported that hearing loss may precede or modulate the onset of cognitive impairment. In this study, we aimed to disentangle the effects of age, hearing loss, and tinnitus on gray matter structure. In total, 39 participants with hearing loss and tinnitus, 21 with hearing loss but without tinnitus, and 39 controls were included in this voxel- and surface-based morphometry MRI study. Whole brain volume and surface thickness measures were compared between the groups. Age-related gray matter volume decline was observed in all groups. Several brain areas showed smaller gray matter volume and cortical surface thickness in hearing loss without tinnitus, relative to controls. This reduction was observed both within and outside of the auditory pathway. Interestingly, these reductions were not observed in participants with tinnitus, who had similar hearing loss and were of similar age. Since we have tools to improve hearing loss, hearing screening may aid in the battle against cognitive decline.

scholarly journals An MRI study of age-related white and gray matter volume changes in the rhesus monkey

2008 ◽  
Vol 29 (10) ◽  
pp. 1563-1575 ◽  
Author(s):  
Jonathan J. Wisco ◽  
Ronald J. Killiany ◽  
Charles R.G. Guttmann ◽  
Simon K. Warfield ◽  
Mark B. Moss ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Volume Changes ◽  
Matter Volume ◽  
Age Related ◽  
Mri Study

scholarly journals Protective Effect of Human Leukocyte Antigen (HLA) Allele DRB1*13:02 on Age-Related Brain Gray Matter Volume Reduction in Healthy Women

EBioMedicine ◽  
2018 ◽  
Vol 29 ◽  
pp. 31-37 ◽  
Author(s):  
Lisa M. James ◽  
Peka Christova ◽  
Scott M. Lewis ◽  
Brian E. Engdahl ◽  
Angeliki Georgopoulos ◽  
...  
Keyword(s):  
Protective Effect ◽  
Human Leukocyte Antigen ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Human Leukocyte ◽  
Volume Reduction ◽  
Leukocyte Antigen ◽  
Matter Volume ◽  
Age Related ◽  
Allele Drb1

scholarly journals Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load

Neurology ◽  
2017 ◽  
Vol 88 (6) ◽  
pp. 569-576 ◽  
Author(s):  
Michel J. Grothe ◽  
Sylvia Villeneuve ◽  
Martin Dyrba ◽  
David Bartrés-Faz ◽  
Miranka Wirth ◽  
...  
Keyword(s):  
Sex Education ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Older Individuals ◽  
Multimodal Neuroimaging ◽  
Matter Volume ◽  
Amyloid Pathology ◽  
Aged Brain ◽  
Age Related ◽  
Amyloid Load

Objective:To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach.Methods:Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairment) enrolled in the Alzheimer's Disease Neuroimaging Initiative and included assessments of regional amyloid load with AV45-PET, glucose metabolism with fluorodeoxyglucose-PET, and gray matter volume with structural MRI. Imaging indexes of APOE2 carriers were contrasted to risk-neutral APOE3 homozygotes, and analyses were controlled for age, sex, education, and clinical diagnosis. Additional models examined genotype-specific effects of age on the imaging markers.Results:In region-of-interest–based analyses, APOE2 carriers had significantly less precuneal amyloid pathology and did not show the typical age-related increase in amyloid load, although the age × genotype interaction was only trend-level significant. In contrast, parietal metabolism and hippocampal volume did not differ between APOE2 and APOE3 genotypes, and both groups showed comparable negative effects of age on these markers. The amyloid specificity of APOE2-related brain changes was corroborated in 2 complementary analyses: spatially unbiased voxel-wise analyses showing widespread reductions in amyloid deposition but no differences in gray matter volume or metabolism and an analysis of CSF-based biomarkers showing a significant effect on amyloid but not on tau pathology.Conclusions:Regarding the range of Alzheimer disease biomarkers considered in the present study, the APOE2 allele appears to have a relatively selective effect on reduced accumulation of amyloid pathology in the aged brain.

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