Associations Between the Subjective Cognitive Decline-Questionnaire’s Scores, Gray Matter Volume, and Amyloid-β Levels

2019 ◽  
Vol 72 (4) ◽  
pp. 1287-1302
Author(s):  
Natalia Valech ◽  
Gonzalo Sánchez-Benavides ◽  
Adrià Tort-Merino ◽  
Nina Coll-Padrós ◽  
Jaume Olives ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Amyloid Β ◽  
Subjective Cognitive Decline ◽  
Matter Volume

Reduced Gray Matter Volume in Subjective Cognitive Decline: A Voxel-Based Morphometric Study

2015 ◽  
Vol 14 (4) ◽  
pp. 143
Author(s):  
Yoonjae Choi ◽  
Byung-Nam Yoon ◽  
Seong Hye Choi ◽  
Myung Kwan Lim ◽  
Hee-Jin Kim ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Subjective Cognitive Decline ◽  
Morphometric Study ◽  
Matter Volume

scholarly journals Moderating Effect of Insulin Resistance on the Relationship between Gray Matter Volumes and Cognitive Function

2018 ◽  
Vol 7 (11) ◽  
pp. 413 ◽  
Author(s):  
Jiyeon Lee ◽  
Jihyeon Kim ◽  
Seong Shin ◽  
Soowon Park ◽  
Dong Yoon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Structural Changes ◽  
Gray Matter Volume ◽  
Volume Loss ◽  
Matter Volume

Background: It is controversial whether exposure to insulin resistance accelerates cognitive deterioration. The present study aimed to investigate the association between insulin resistance and gray matter volume loss to predict the cognitive decline. Methods: We recruited 160 participants (78 with Alzheimer’s disease and 82 without Alzheimer’s disease). Insulin resistance, regional gray matter volume, and cognitive function were assessed. A hierarchical moderated multiple regression (MMR) model was used to determine any associations among insulin resistance, structural changes in the brain, and cognitive decline. Results: The volumes of 7 regions in the gray matter were negatively related to insulin resistance in Alzheimer’s disease (p =0.032). Hierarchical MMR analysis indicated that insulin resistance did not directly affect the cognitive decline but moderated the cognitive decline through the decrease in gray matter volume in the key brain regions, i.e., inferior orbitofrontal gyrus (left), middle cingulate gyrus (right), hippocampus (right), and precuneus (right) (p < 0.05 in each case). Conclusion: Insulin resistance appears to exacerbate the cognitive decline associated with several gray matter volume loss.

scholarly journals Gray matter volume and estimated brain age gap are not associated with sleep-disordered breathing in subjects from the ADNI cohort

2019 ◽  
Author(s):  
Bahram Mohajer ◽  
Nooshin Abbasi ◽  
Esmaeil Mohammadi ◽  
Habibolah Khazaie ◽  
Ricardo S. Osorio ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Sleep Disordered Breathing ◽  
Brain Aging ◽  
Gray Matter Volume ◽  
Cognitive Status ◽  
Matter Volume ◽  
Disordered Breathing

AbstractAlzheimer’s disease (AD) and sleep-disordered breathing (SDB) are prevalent conditions with rising burden. It is suggested that SDB may contribute to cognitive decline and advanced aging. Here, we assessed the link between self-reported SDB and gray matter volume in patients with AD, mild cognitive impairment (MCI) and healthy controls (HC). We further investigated whether SDB was associated with advanced brain aging. We included a total of 330 participants, divided based on self-reported history of SDB, and matched across diagnoses for age, sex and presence of the ApoE4 allele, from the Alzheimer’s Disease Neuroimaging Initiative. Gray-matter volume was measured using voxel-wise morphometry and differences reflecting SDB, cognitive status, and their interaction were evaluated. Further, using an age-prediction model fitted on gray-matter data of external datasets, we predicted study participants’ age from their structural scans. Cognitive decline (MCI/AD diagnosis) and advanced age were associated with lower gray matter volume in various regions, particularly in the bilateral temporal lobes. BrainAGE was well predicted from the morphological data in HC and, as expected, elevated in MCI and particularly in AD. However, there was neither a significant difference between regional gray matter volume in any diagnostic group related to the SDB status nor an SDB-by-cognitive status interaction. Also, we found neither a significant difference in BrainAGE gap (estimated - chronological age) related to SDB nor an SDB-by-cognitive status interaction. In summary, contrary to our expectations, we were not able to find a general nor a diagnostic specific effect on either gray-matter volumetric or brain aging.Statement of significanceDementia syndromes including Alzheimer’s disease (AD), are a major global concern, and unraveling modifiable predisposing risk factors is indispensable. Sleep-disordered breathing (SDB) and its most prevalent form, obstructive sleep apnea, are suggested as modifiable risk factors of AD, but their contribution to AD hallmarks, like brain atrophy and advanced brain aging, is not clear to this day. While self-reported SDB is suggested to propagate aging process and cognitive decline to AD in clinical studies, here, we demonstrated that, SDB might not necessarily associate to brain atrophy and the advanced brain aging assessed by morphological data, in AD progession. However, multimodal longitudinal studies with polysomnographic assessment of SDB are needed to confirm such fundings.

scholarly journals Physical activity and inflammation: effects on gray-matter volume and cognitive decline in aging

2016 ◽  
Vol 37 (10) ◽  
pp. 3462-3473 ◽  
Author(s):  
Goran Papenberg ◽  
Beata Ferencz ◽  
Francesca Mangialasche ◽  
Patrizia Mecocci ◽  
Roberta Cecchetti ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume

scholarly journals Gray matter declines with age and hearing loss, but is partially maintained in tinnitus

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Elouise A. Koops ◽  
Emile de Kleine ◽  
Pim van Dijk
Keyword(s):  
Hearing Loss ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Auditory Pathway ◽  
Brain Areas ◽  
Matter Volume ◽  
Age Related ◽  
Surface Thickness

AbstractThe impact of age-related hearing loss extends beyond the auditory pathway and impacts brain areas related to cognitive impairment and even dementia. The presence of tinnitus, a sensation of sound that frequently co-occurs with hearing loss, is additionally linked to cognitive decline. Interestingly, structural neuroimaging studies have reported that hearing loss may precede or modulate the onset of cognitive impairment. In this study, we aimed to disentangle the effects of age, hearing loss, and tinnitus on gray matter structure. In total, 39 participants with hearing loss and tinnitus, 21 with hearing loss but without tinnitus, and 39 controls were included in this voxel- and surface-based morphometry MRI study. Whole brain volume and surface thickness measures were compared between the groups. Age-related gray matter volume decline was observed in all groups. Several brain areas showed smaller gray matter volume and cortical surface thickness in hearing loss without tinnitus, relative to controls. This reduction was observed both within and outside of the auditory pathway. Interestingly, these reductions were not observed in participants with tinnitus, who had similar hearing loss and were of similar age. Since we have tools to improve hearing loss, hearing screening may aid in the battle against cognitive decline.

scholarly journals Regional Gray Matter Volume Links Rest-Activity Rhythm Fragmentation With Past Cognitive Decline

2020 ◽  
Vol 28 (2) ◽  
pp. 248-251 ◽  
Author(s):  
Stephen F. Smagula ◽  
Lana Chahine ◽  
Andrea Metti ◽  
Anusha Rangarajan ◽  
Howard J. Aizenstein ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Gray Matter ◽  
Activity Rhythm ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Rest Activity

Reduced gray matter volume in cognitively preserved COMT 158Val/Val Parkinson’s disease patients and its association with cognitive decline

2019 ◽  
Vol 14 (2) ◽  
pp. 321-328 ◽  
Author(s):  
Frederic Sampedro ◽  
Juan Marín-Lahoz ◽  
Saul Martínez-Horta ◽  
Javier Pagonabarraga ◽  
Jaime Kulisevsky
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume

scholarly journals Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline

2018 ◽  
Vol 9 ◽  
Author(s):  
Frederic Sampedro ◽  
Juan Marín-Lahoz ◽  
Saul Martínez-Horta ◽  
Javier Pagonabarraga ◽  
Jaime Kulisevsky
Keyword(s):  
Cognitive Decline ◽  
Gray Matter ◽  
De Novo ◽  
Gray Matter Volume ◽  
Volume Loss ◽  
Matter Volume
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