scholarly journals Commentary on “Sex differences in the effect of cannabinoid type 1 receptor deletion on locus coeruleus-norepinephrine neurons and corticotropin releasing factor-mediated responses”

2019 ◽  
Vol 49 (10) ◽  
pp. 1210-1211
Author(s):  
Luke John Ney ◽  
Allison Matthews ◽  
Raimondo Bruno ◽  
Kim Louise Felmingham
Keyword(s):  
Sex Differences ◽  
Locus Coeruleus ◽  
Corticotropin Releasing Factor ◽  
Cannabinoid Type 1 Receptor

Sex differences in morphine-induced trafficking of mu-opioid and corticotropin-releasing factor receptors in locus coeruleus neurons

2019 ◽  
Vol 1706 ◽  
pp. 75-85 ◽  
Author(s):  
Nicole M. Enman ◽  
Beverly A.S. Reyes ◽  
Yufan Shi ◽  
Rita J. Valentino ◽  
Elisabeth J. Van Bockstaele
Keyword(s):  
Sex Differences ◽  
Locus Coeruleus ◽  
Corticotropin Releasing Factor ◽  
Mu Opioid

Sex Differences in Neuropathy and Neuropathic Pain in Long-Standing Diabetes—Results from the Canadian Study of Longevity in Type 1 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 560-P
Author(s):  
NANCY CARDINEZ ◽  
LEIF ERIK LOVBLOM ◽  
JOHNNY-WEI BAI ◽  
ALON ABRAHAM ◽  
EVAN J. LEWIS ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Sex Differences ◽  
Neuropathic Pain ◽  
Canadian Study

Dimerization of Corticotropin-Releasing Factor Receptor Type 1 Is Not Coupled to Ligand Binding

2005 ◽  
Vol 25 (4-6) ◽  
pp. 251-276 ◽  
Author(s):  
OLIVER KRAETKE ◽  
BURKHARD WIESNER ◽  
JENNY EICHHORST ◽  
JENS FURKERT ◽  
MICHAEL BIENERT ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Corticotropin Releasing Factor ◽  
Receptor Type

Estrogen Deficiency and Colonic Function: Surgical Menopause and Sex Differences in Angiotensin and Dopamine Receptor Interaction

2020 ◽  
Author(s):  
Pablo Garrido-Gil ◽  
Ana I Rodriguez-Perez ◽  
Lucia Lage ◽  
Jose L Labandeira-Garcia
Keyword(s):  
Sex Differences ◽  
Dopamine Receptors ◽  
D2 Receptor ◽  
Renin Angiotensin System ◽  
Receptor Expression ◽  
Oxidative Markers ◽  
Mutual Regulation ◽  
Inflammatory Processes ◽  
Angiotensin Type

Abstract The physiopathological mechanisms that regulate menopausal and sex differences in colonic transit, inflammatory processes, and efficacy of treatments have not been clarified. The dopaminergic system and renin–angiotensin system coexist in the gut and regulate different processes such as motility, absorption/secretion, and inflammation. We investigated the changes in expression of major angiotensin and dopamine receptors in the colon of male, female, and ovariectomized female mice. Possible interaction between both systems was investigated using male and female mice deficient (ko) for major angiotensin and dopamine receptors. In wild-type mice, colonic tissue from females showed lower angiotensin type 1/angiotensin type 2 ratio (an index of pro-inflammatory/anti-inflammatory renin–angiotensin system balance), lower dopamine D1 and D2 receptor expression, and lower levels of pro-inflammatory and pro-oxidative markers relative to males. Interestingly, ovariectomy increased the expression of pro-inflammatory angiotensin type 1 receptor expression and decreased anti-inflammatory angiotensin type 2 receptor expression, increased D1 and D2 receptor expression, and increased the levels of pro-inflammatory and pro-oxidative markers. Ovariectomy-induced changes were blocked by estrogen replacement. The present results suggest a mutual regulation between colonic angiotensin and dopamine receptors and sex differences in this mutual regulation. Estrogen regulates changes in both angiotensin and dopamine receptor expression, which may be involved in sex- and surgical menopause-related effects on gut motility, permeability, and vulnerability to inflammatory processes.

scholarly journals Molecular Docking and Molecular Dynamics Simulation Studies of Triterpenes from Vernonia patula with the Cannabinoid Type 1 Receptor

2021 ◽  
Vol 22 (7) ◽  
pp. 3595
Author(s):  
Md Afjalus Afjalus Siraj ◽  
Md. Sajjadur Rahman ◽  
Ghee T. Tan ◽  
Veronique Seidel
Keyword(s):  
Molecular Dynamics ◽  
Molecular Docking ◽  
Molecular Dynamics Simulation ◽  
Binding Affinity ◽  
Docking Studies ◽  
Dynamics Simulation ◽  
Simulation Studies ◽  
Cannabinoid Type 1 Receptor ◽  
Docking Approach

A molecular docking approach was employed to evaluate the binding affinity of six triterpenes, namely epifriedelanol, friedelin, α-amyrin, α-amyrin acetate, β-amyrin acetate, and bauerenyl acetate, towards the cannabinoid type 1 receptor (CB1). Molecular docking studies showed that friedelin, α-amyrin, and epifriedelanol had the strongest binding affinity towards CB1. Molecular dynamics simulation studies revealed that friedelin and α-amyrin engaged in stable non-bonding interactions by binding to a pocket close to the active site on the surface of the CB1 target protein. The studied triterpenes showed a good capacity to penetrate the blood–brain barrier. These results help to provide some evidence to justify, at least in part, the previously reported antinociceptive and sedative properties of Vernonia patula.

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