Role of Cannabinoid Type 1 Receptor in Locus Coeruleus Activity

2021 ◽  
Author(s):  
Ryan Rudolph Wyrofsky
Keyword(s):  
Locus Coeruleus ◽  
Cannabinoid Type 1 Receptor

Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity

2010 ◽  
Vol 11 (5) ◽  
pp. 693-702 ◽  
Author(s):  
Dorit Schleinitz ◽  
Solveig Carmienke ◽  
Yvonne Böttcher ◽  
Anke Tönjes ◽  
Janin Berndt ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Receptor Gene ◽  
Human Obesity ◽  
Cannabinoid Type 1 Receptor

scholarly journals The role of orexin type-1 receptors in the development of morphine tolerance in locus coeruleus neurons: An electrophysiological perspective

2016 ◽  
Vol 1646 ◽  
pp. 91-97 ◽  
Author(s):  
Hakime Abdollahi ◽  
Masoumeh Ghaemi-Jandabi ◽  
Hossein Azizi ◽  
Saeed Semnanian
Keyword(s):  
Locus Coeruleus ◽  
Morphine Tolerance

scholarly journals Forebrain-Specific Inactivation of Gq/G11 Family G Proteins Results in Age-Dependent Epilepsy and Impaired Endocannabinoid Formation

2006 ◽  
Vol 26 (15) ◽  
pp. 5888-5894 ◽  
Author(s):  
Nina Wettschureck ◽  
Mario van der Stelt ◽  
Hiroshi Tsubokawa ◽  
Heinz Krestel ◽  
Alexandra Moers ◽  
...  
Keyword(s):  
G Proteins ◽  
Neuronal Excitability ◽  
Metabotropic Receptors ◽  
Cannabinoid Type 1 Receptor ◽  
Age Dependent ◽  
Α Subunits ◽  
Increased Susceptibility

ABSTRACT Metabotropic receptors coupled to Gq/G11 family G proteins critically contribute to nervous system functions by modulating synaptic transmission, often facilitating excitation. We investigated the role of Gq/G11 family G proteins in the regulation of neuronal excitability in mice that selectively lack the α-subunits of Gq and G11, Gαq and Gα11, respectively, in forebrain principal neurons. Surprisingly, mutant mice exhibited increased seizure susceptibility, and the activation of neuroprotective mechanisms was impaired. We found that endocannabinoid levels were reduced under both basal and excitotoxic conditions and that increased susceptibility to kainic acid could be normalized by the enhancement of endocannabinoid levels with an endocannabinoid reuptake inhibitor, while the competitive cannabinoid type 1 receptor antagonist SR141716A did not cause further aggravation. These findings indicate that Gq/G11 family G proteins negatively regulate neuronal excitability in vivo and suggest that impaired endocannabinoid formation in the absence of Gq/G11 contributes to this phenotype.

Role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of peptic ulcer disease

2001 ◽  
Vol 120 (5) ◽  
pp. A136-A137
Author(s):  
K TSAMAKIDES ◽  
E PANOTOPOULOU ◽  
D DIMITROULOPOULOS ◽  
M CHRISTOPOULO ◽  
D XINOPOULOS ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Peptic Ulcer Disease ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Ulcer Disease ◽  
Simplex Virus
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